Use of functionalized aromatic organozinc reagents in the three-component Mannich-type synthesis of diarylmethylamines

Use of functionalized aromatic organozinc reagents in the three-component Mannich-type synthesis of diarylmethylamines

Efficient syntheses of functionalized diarylmethylamines have been realized according to a one-step three-component coupling between an aromatic aldehyde, a secondary amine and an aromatic organozinc reagent. Phenyl rings can be substituted by functional groups and either aromatic or non-aromatic am...

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Veröffentlicht in:Tetrahedron letters 2006-04, Vol.47 (15), p.2497-2500
Hauptverfasser: Le Gall, Erwan, Troupel, Michel, Nédélec, Jean-Yves
Format: Artikel
Sprache:eng
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Aromatic aldehydes
Aromatic organozinc reagents
Diarylmethylamines
Secondary amines
Three-component reaction
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container_end_page 2500
container_issue 15
container_start_page 2497
container_title Tetrahedron letters
container_volume 47
creator Le Gall, Erwan
Troupel, Michel
Nédélec, Jean-Yves
description Efficient syntheses of functionalized diarylmethylamines have been realized according to a one-step three-component coupling between an aromatic aldehyde, a secondary amine and an aromatic organozinc reagent. Phenyl rings can be substituted by functional groups and either aromatic or non-aromatic amines can be used in this process.
doi_str_mv 10.1016/j.tetlet.2006.02.056
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1873-3581
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subjects Aromatic aldehydes
Aromatic organozinc reagents
Diarylmethylamines
Secondary amines
Three-component reaction
title Use of functionalized aromatic organozinc reagents in the three-component Mannich-type synthesis of diarylmethylamines
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