The depressant scorpion neurotoxin LqqIT2 selectively modulates the insect voltage-gated sodium channel

LqqIT2 is a depressant neurotoxin present in the venom of the Leiurus quinquestriatus quinquestriatus scorpion, one of the world's most dangerous scorpions endemic to dry habitats in Africa and Asia. In order to determine its efficacy, potency and selectivity, LqqIT2 was subjected for the first...

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Veröffentlicht in:	Toxicon (Oxford) 2005-03, Vol.45 (4), p.501-507
Hauptverfasser:	Bosmans, Frank, Martin-Eauclaire, Marie-France, Tytgat, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animal poisons toxicology. Antivenoms Animals Biological and medical sciences Depressant scorpion toxin Drosophila Proteins - drug effects Drosophila Proteins - metabolism Electrophysiology Freshwater Insecticide Leiurus quinquestriatus quinquestriatus LqqIT2 Medical sciences Membrane Proteins - drug effects Membrane Proteins - metabolism Molecular Sequence Data NAV1.2 Voltage-Gated Sodium Channel Nerve Tissue Proteins - drug effects Nerve Tissue Proteins - metabolism Oocytes - metabolism Patch-Clamp Techniques Rats Scorpion Venoms - genetics Scorpion Venoms - pharmacology Scorpions - chemistry Sequence Alignment Sodium Channels - drug effects Sodium Channels - metabolism Species Specificity Toxicology Xenopus laevis
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