Novel biomaterials for bisphosphonate delivery

One type of gem-bisphosphonate (Zoledronate) has been chemically associated onto calcium phosphate (CaP) compounds of various compositions. For that purpose, CaP powders of controlled granulometry have been suspended in aqueous Zoledronate solutions of variable concentrations. Using mainly 31P NMR s...

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Veröffentlicht in:	Biomaterials 2005-05, Vol.26 (14), p.2073-2080
Hauptverfasser:	Josse, Solen, Faucheux, Corinne, Soueidan, A., Grimandi, Gaël, Massiot, Dominique, Alonso, Bruno, Janvier, Pascal, Laı̈b, Samia, Pilet, Paul, Gauthier, Olivier, Daculsi, Guy, Guicheux, Jérôme, Bujoli, Bruno, Bouler, Jean-Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apatite structure Biocompatible Materials - chemistry Bone Resorption - pathology Bone Resorption - prevention & control Calcium phosphate Calcium Phosphates - chemistry Cells, Cultured Diphosphonates - administration & dosage Diphosphonates - chemistry Drug Carriers - chemistry Drug Implants - administration & dosage Drug Implants - chemistry Drug release Imidazoles - administration & dosage Imidazoles - chemistry Materials Testing Osteoblasts - drug effects Osteoblasts - pathology Osteoclast Rabbits Surface Properties
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