Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia

In this study, we explored the telomeric changes that occur in B-chronic lymphocytic leukemia (B-CLL), in which telomere length has recently been demonstrated to be a powerful prognostic marker. We carried out a transcriptomic analysis of telomerase components (hTERT and DYSKERIN), shelterin protein...

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Veröffentlicht in:	Blood 2008-02, Vol.111 (4), p.2388-2391
Hauptverfasser:	Poncet, Delphine, Belleville, Aurélie, t'Kint de Roodenbeke, Claire, Roborel de Climens, Aude, Ben Simon, Elsa, Merle-Beral, Hélène, Callet-Bauchu, Evelyne, Salles, Gilles, Sabatier, Laure, Delic, Jozo, Gilson, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD19 - blood Biological and medical sciences Gene Expression Profiling Gene Expression Regulation, Neoplastic Hematologic and hematopoietic diseases Humans Leukemia, Lymphocytic, Chronic, B-Cell - enzymology Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Life Sciences Medical sciences Mutation Telomerase - genetics Telomere - genetics Telomere - ultrastructure
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