Impact of Airborne Particle Size, Acoustic Airflow and Breathing Pattern on Delivery of Nebulized Antibiotic into the Maxillary Sinuses Using a Realistic Human Nasal Replica

ABSTRACT Purpose Improvement of clinical outcome in patients with sinuses disorders involves targeting delivery of nebulized drug into the maxillary sinuses. We investigated the impact of nebulization conditions (with and without 100 Hz acoustic airflow), particle size (9.9 μm, 2.8 μm, 550 nm and 23...

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Veröffentlicht in:	Pharmaceutical research 2014-09, Vol.31 (9), p.2335-2343
Hauptverfasser:	Leclerc, Lara, Pourchez, Jérémie, Aubert, Gérald, Leguellec, Sandrine, Vecellio, Laurent, Cottier, Michèle, Durand, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustics Administration, Intranasal Adult Aerosols - chemistry Airborne particulates Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - chemistry Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Chemical and Process Engineering Drug Delivery Systems Engineering Sciences Environmental impact Equipment Design Gentamicins - administration & dosage Gentamicins - chemistry Human health and pathology Humans Life Sciences Male Maxillary Sinus - anatomy & histology Maxillary Sinus - physiology Medical Law Models, Anatomic Nebulizers and Vaporizers Nose Nose - anatomy & histology Nose - physiology Particle Size Pharmacology/Toxicology Pharmacy Pulmonology and respiratory tract Research Paper Respiration Sinuses
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