Influence of SNPs in nutrient-sensitive candidate genes and gene–diet interactions on blood lipids: the DiOGenes study
Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene–diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile aft...
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| Veröffentlicht in: | British journal of nutrition 2013-09, Vol.110 (5), p.790-796 |
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| creator | Brahe, Lena K. Ängquist, Lars Larsen, Lesli H. Vimaleswaran, Karani S. Hager, Jörg Viguerie, Nathalie Loos, Ruth J. F. Handjieva-Darlenska, Teodora Jebb, Susan A. Hlavaty, Petr Larsen, Thomas M. Martinez, J. Alfredo Papadaki, Angeliki Pfeiffer, Andreas F. H. van Baak, Marleen A. Sørensen, Thorkild I. A. Holst, Claus Langin, Dominique Astrup, Arne Saris, Wim H. M. |
| description | Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene–diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP–diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect), and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP–dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of − 0·26 mmol/l per A-allele/protein unit (95 % CI − 0·38, − 0·14, P= 0·000043). In conclusion, we investigated SNP–diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration. |
| doi_str_mv | 10.1017/S0007114512006058 |
| format | Article |
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F. ; Handjieva-Darlenska, Teodora ; Jebb, Susan A. ; Hlavaty, Petr ; Larsen, Thomas M. ; Martinez, J. Alfredo ; Papadaki, Angeliki ; Pfeiffer, Andreas F. H. ; van Baak, Marleen A. ; Sørensen, Thorkild I. A. ; Holst, Claus ; Langin, Dominique ; Astrup, Arne ; Saris, Wim H. M.</creator><creatorcontrib>Brahe, Lena K. ; Ängquist, Lars ; Larsen, Lesli H. ; Vimaleswaran, Karani S. ; Hager, Jörg ; Viguerie, Nathalie ; Loos, Ruth J. F. ; Handjieva-Darlenska, Teodora ; Jebb, Susan A. ; Hlavaty, Petr ; Larsen, Thomas M. ; Martinez, J. Alfredo ; Papadaki, Angeliki ; Pfeiffer, Andreas F. H. ; van Baak, Marleen A. ; Sørensen, Thorkild I. A. ; Holst, Claus ; Langin, Dominique ; Astrup, Arne ; Saris, Wim H. M.</creatorcontrib><description>Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene–diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP–diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect), and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP–dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of − 0·26 mmol/l per A-allele/protein unit (95 % CI − 0·38, − 0·14, P= 0·000043). In conclusion, we investigated SNP–diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114512006058</identifier><identifier>PMID: 23360819</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Activating Transcription Factor 6 - genetics ; Activating Transcription Factor 6 - metabolism ; Adult ; Biological and medical sciences ; Blood ; Cholesterol ; Cholesterol, HDL - genetics ; Cholesterol, HDL - metabolism ; Diet ; Dietary Proteins - metabolism ; Diogenes ; Fatty Acid-Binding Proteins - genetics ; Fatty Acid-Binding Proteins - metabolism ; Feeding. Feeding behavior ; Female ; Food and Nutrition ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation - drug effects ; Gene Expression Regulation - physiology ; Genes ; Glycemic Index - physiology ; Humans ; Life Sciences ; Lipid Metabolism - genetics ; Lipid Metabolism - physiology ; Lipids ; Lipids - blood ; Lipoprotein Lipase - genetics ; Lipoprotein Lipase - metabolism ; Male ; Metabolism ; Molecular Nutrition ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; Nutrients ; Nutrition ; Obesity ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ; Phosphatidate Phosphatase - genetics ; Phosphatidate Phosphatase - metabolism ; Polymorphism ; Polymorphism, Single Nucleotide ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>British journal of nutrition, 2013-09, Vol.110 (5), p.790-796</ispartof><rights>Copyright © The Authors 2013</rights><rights>2014 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-1ed85910bf1fdedcefccfbdc1fdbd278c3e292d8402f5ec06d17a511fdaa2b823</citedby><cites>FETCH-LOGICAL-c513t-1ed85910bf1fdedcefccfbdc1fdbd278c3e292d8402f5ec06d17a511fdaa2b823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114512006058/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,230,314,780,784,885,27924,27925,55628</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27667200$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23360819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://cea.hal.science/cea-04675672$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Brahe, Lena K.</creatorcontrib><creatorcontrib>Ängquist, Lars</creatorcontrib><creatorcontrib>Larsen, Lesli H.</creatorcontrib><creatorcontrib>Vimaleswaran, Karani S.</creatorcontrib><creatorcontrib>Hager, Jörg</creatorcontrib><creatorcontrib>Viguerie, Nathalie</creatorcontrib><creatorcontrib>Loos, Ruth J. F.</creatorcontrib><creatorcontrib>Handjieva-Darlenska, Teodora</creatorcontrib><creatorcontrib>Jebb, Susan A.</creatorcontrib><creatorcontrib>Hlavaty, Petr</creatorcontrib><creatorcontrib>Larsen, Thomas M.</creatorcontrib><creatorcontrib>Martinez, J. Alfredo</creatorcontrib><creatorcontrib>Papadaki, Angeliki</creatorcontrib><creatorcontrib>Pfeiffer, Andreas F. H.</creatorcontrib><creatorcontrib>van Baak, Marleen A.</creatorcontrib><creatorcontrib>Sørensen, Thorkild I. A.</creatorcontrib><creatorcontrib>Holst, Claus</creatorcontrib><creatorcontrib>Langin, Dominique</creatorcontrib><creatorcontrib>Astrup, Arne</creatorcontrib><creatorcontrib>Saris, Wim H. M.</creatorcontrib><title>Influence of SNPs in nutrient-sensitive candidate genes and gene–diet interactions on blood lipids: the DiOGenes study</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene–diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP–diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect), and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP–dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of − 0·26 mmol/l per A-allele/protein unit (95 % CI − 0·38, − 0·14, P= 0·000043). In conclusion, we investigated SNP–diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration.</description><subject>Activating Transcription Factor 6 - genetics</subject><subject>Activating Transcription Factor 6 - metabolism</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Cholesterol</subject><subject>Cholesterol, HDL - genetics</subject><subject>Cholesterol, HDL - metabolism</subject><subject>Diet</subject><subject>Dietary Proteins - metabolism</subject><subject>Diogenes</subject><subject>Fatty Acid-Binding Proteins - genetics</subject><subject>Fatty Acid-Binding Proteins - metabolism</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Food and Nutrition</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Gene Expression Regulation - physiology</subject><subject>Genes</subject><subject>Glycemic Index - physiology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Lipid Metabolism - genetics</subject><subject>Lipid Metabolism - physiology</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Lipoprotein Lipase - genetics</subject><subject>Lipoprotein Lipase - metabolism</subject><subject>Male</subject><subject>Metabolism</subject><subject>Molecular Nutrition</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - metabolism</subject><subject>Nutrients</subject><subject>Nutrition</subject><subject>Obesity</subject><subject>Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha</subject><subject>Phosphatidate Phosphatase - genetics</subject><subject>Phosphatidate Phosphatase - metabolism</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kc9u1DAQxi0EokvhAbggSwgJDgGPk9gJt6pAW2lFkQrnyLHHrausvbWdit54B96QJ8HbXQoCcZoZfb9v_mgIeQrsNTCQb84YYxKgaYEzJljb3SMLaGRbcSH4fbLYyNVG3yOPUrosZQesf0j2eF2LkvcL8vXE22lGr5EGS88-fkrUeernHB36XCX0yWV3jVQrb5xRGek5eky0lLfZj2_fjcNcXBmj0tkFn2jwdJxCMHRya2fSW5ovkL5zp0e31pRnc_OYPLBqSvhkF_fJlw_vPx8eV8vTo5PDg2WlW6hzBWi6tgc2WrAGjUartR2NLtVouOx0jbznpmsYty1qJgxI1UKRleJjx-t98mrb90JNwzq6lYo3Q1BuOD5YDhrVwBohWyH5NRT25ZZdx3A1Y8rDyiWN06Q8hjkN0PRc1I0QXUGf_4Vehjn6ckmhCtTXvWwKBVtKx5BSRHu3AbBh88LhnxcWz7Nd53lcoblz_PpZAV7sAJW0mmxUXrv0m5OiXMNY4erdcLUaozPn-MeO_x3_E6qws9g</recordid><startdate>20130914</startdate><enddate>20130914</enddate><creator>Brahe, Lena K.</creator><creator>Ängquist, Lars</creator><creator>Larsen, Lesli H.</creator><creator>Vimaleswaran, Karani S.</creator><creator>Hager, Jörg</creator><creator>Viguerie, Nathalie</creator><creator>Loos, Ruth J. 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The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP–diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect), and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP–dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of − 0·26 mmol/l per A-allele/protein unit (95 % CI − 0·38, − 0·14, P= 0·000043). In conclusion, we investigated SNP–diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>23360819</pmid><doi>10.1017/S0007114512006058</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of nutrition, 2013-09, Vol.110 (5), p.790-796 |
| issn | 0007-1145 1475-2662 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_cea_04675672v1 |
| source | MEDLINE; Cambridge Journals; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Activating Transcription Factor 6 - genetics Activating Transcription Factor 6 - metabolism Adult Biological and medical sciences Blood Cholesterol Cholesterol, HDL - genetics Cholesterol, HDL - metabolism Diet Dietary Proteins - metabolism Diogenes Fatty Acid-Binding Proteins - genetics Fatty Acid-Binding Proteins - metabolism Feeding. Feeding behavior Female Food and Nutrition Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Genes Glycemic Index - physiology Humans Life Sciences Lipid Metabolism - genetics Lipid Metabolism - physiology Lipids Lipids - blood Lipoprotein Lipase - genetics Lipoprotein Lipase - metabolism Male Metabolism Molecular Nutrition Nuclear Proteins - genetics Nuclear Proteins - metabolism Nutrients Nutrition Obesity Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Phosphatidate Phosphatase - genetics Phosphatidate Phosphatase - metabolism Polymorphism Polymorphism, Single Nucleotide Transcription Factors - genetics Transcription Factors - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Influence of SNPs in nutrient-sensitive candidate genes and gene–diet interactions on blood lipids: the DiOGenes study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T13%3A08%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20SNPs%20in%20nutrient-sensitive%20candidate%20genes%20and%20gene%E2%80%93diet%20interactions%20on%20blood%20lipids:%20the%20DiOGenes%20study&rft.jtitle=British%20journal%20of%20nutrition&rft.au=Brahe,%20Lena%20K.&rft.date=2013-09-14&rft.volume=110&rft.issue=5&rft.spage=790&rft.epage=796&rft.pages=790-796&rft.issn=0007-1145&rft.eissn=1475-2662&rft.coden=BJNUAV&rft_id=info:doi/10.1017/S0007114512006058&rft_dat=%3Cproquest_hal_p%3E3049644751%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1426393974&rft_id=info:pmid/23360819&rft_cupid=10_1017_S0007114512006058&rfr_iscdi=true |