Research Priorities on the Role of α‐Synuclein in Parkinson's Disease Pathogenesis
Various forms of Parkinson's disease, including its common sporadic form, are characterized by prominent α‐synuclein (αSyn) aggregation in affected brain regions. However, the role of αSyn in the pathogenesis and evolution of the disease remains unclear, despite vast research efforts of more th...
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| creator | Burré, Jacqueline Edwards, Robert H. Halliday, Glenda Lang, Anthony E. Lashuel, Hilal A. Melki, Ronald Murayama, Shigeo Outeiro, Tiago F. Papa, Stella M. Stefanis, Leonidas Woerman, Amanda L. Surmeier, Dalton James Kalia, Lorraine V. Takahashi, Ryosuke Olsen, Abby Surmeier, Dalton James Bayram, Ece Chaing, Han‐Lin Lee, Jee Young Peall, Kathryn Lohmann, Katja Zeuner, Kirsten Kalia, Lorraine Cornejo‐Olivas, Mario Calabresi, Paolo Takahashi, Ryosuke Przedborski, Serge |
| description | Various forms of Parkinson's disease, including its common sporadic form, are characterized by prominent α‐synuclein (αSyn) aggregation in affected brain regions. However, the role of αSyn in the pathogenesis and evolution of the disease remains unclear, despite vast research efforts of more than a quarter century. A better understanding of the role of αSyn, either primary or secondary, is critical for developing disease‐modifying therapies. Previous attempts to hone this research have been challenged by experimental limitations, but recent technological advances may facilitate progress. The Scientific Issues Committee of the International Parkinson and Movement Disorder Society (MDS) charged a panel of experts in the field to discuss current scientific priorities and identify research strategies with potential for a breakthrough. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. |
| doi_str_mv | 10.1002/mds.29897 |
| format | Article |
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| identifier | ISSN: 0885-3185 |
| ispartof | Movement disorders, 2024-10, Vol.39 (10), p.1663-1678 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | alpha-Synuclein - metabolism Animals Brain - metabolism Humans Lewy pathology Life Sciences Movement disorders neurodegeneration Neurodegenerative diseases Parkinson Disease - metabolism Parkinson's disease Pathogenesis protein aggregation Synuclein α‐synuclein |
| title | Research Priorities on the Role of α‐Synuclein in Parkinson's Disease Pathogenesis |
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