Dopamine D 1 Receptor Agonist PET Tracer Development: Assessment in Nonhuman Primates

Non-catechol-based high-affinity selective dopamine D receptor (D1R) agonists were recently described, and candidate PET ligands were selected on the basis of favorable properties. The objective of this study was to characterize in vivo in nonhuman primates 2 novel D1R agonist PET radiotracers, race...

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Veröffentlicht in:	Journal of Nuclear Medicine 2021-09, Vol.62 (9), p.1307-1313
Hauptverfasser:	Barret, Olivier, Zhang, Lei, Alagille, David, Constantinescu, Cristian C, Sandiego, Christine, Papin, Caroline, Sullivan, Jenna M, Morley, Thomas, Carroll, Vincent M, Seibyl, John, Chen, Jianqing, Lee, Chewah, Villalobos, Anabella, Gray, David, McCarthy, Timothy J, Tamagnan, Gilles
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - diagnostic imaging Brain - metabolism Dopamine Agonists - pharmacokinetics Dopamine Agonists - pharmacology Life Sciences Macaca fascicularis Macaca mulatta Male Positron-Emission Tomography - methods Radioactive Tracers Radiopharmaceuticals - pharmacokinetics Receptors, Dopamine D1 - agonists Receptors, Dopamine D1 - antagonists & inhibitors Receptors, Dopamine D1 - metabolism Tissue Distribution
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