The Michael donor-acceptor reactivity of curcumins in the synthesis of diverse multi-functional scaffolds

Curcumin is a key constituent of turmeric with a variety of biological activities. From a chemical point of view, curcumin contains different functional groups that can undergo multiple transformations such as Michael addition, cycloaddition, click reaction, polymerisation, etc. Among these, Michael-type reactions under benign conditions constitute a captivating domain of curcumin's reactivity. To the best of our knowledge, no review focusing on the Michael donor-acceptor reactivity of curcumins has been published to date. Herein, we have compiled the chemistry of curcumins with respect to their chemical synthesis, biosynthesis, and involvement in chemical transformations, especially in Michael additions with advances in mechanistic aspects and understanding. Curcumin and its analogs, display Michael donor-acceptor ability with various reactants in the presence of bases, Lewis acids and catalysts, under conventional, microwave and mechanochemical conditions and generate diverse synthetic scaffolds.