Uranium exposure of human dopaminergic cells results in low cytotoxicity, accumulation within sub-cytoplasmic regions, and down regulation of MAO-B

•Natural uranium is cytotoxic towards dopaminergic cells but only at high concentrations (> 125 μM) which are not relevant for the vast majority of human exposures.•Uranium is located in defined cytoplasmic regions suggesting its accumulation within organelles yet to be determined.•Among the dopa...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2018-09, Vol.68, p.177-188
Hauptverfasser:	Carmona, Asuncion, Malard, Véronique, Avazeri, Emilie, Roudeau, Stéphane, Porcaro, Francesco, Paredes, Eduardo, Vidaud, Claude, Bresson, Carole, Ortega, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Amine oxidase (flavin-containing) Catabolism Cell Line, Tumor Cell Survival Chronic exposure Cytoplasm Cytoplasm - metabolism Cytotoxicity Dopamine Dopamine receptors Dopaminergic Neurons - metabolism Down-Regulation Emission analysis Exposure Gene expression Genes Human exposure Humans In vitro Intracellular Kidneys Molecular modelling Monoamine Oxidase - metabolism Monoamine oxidase B Neurotoxicity Nuclear Experiment Nuclear Theory Nuclei (cytology) Occupational exposure Occupational health Organelles Phenotypes Physics Proteins Quantitative analysis Subcellular distribution Substrates Toxicity Uranium Uranium - metabolism Uranium - toxicity
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