Brain perfusion alterations induced by standalone and combined non-invasive brain stimulation over the dorsolateral prefrontal cortex
Non-invasive brain stimulation (NIBS) interventions are promising for the treatment of psychiatric disorders. Notwithstanding, the NIBS mechanisms of action over the dorsolateral prefrontal cortex (DLPFC), a hub that modulates affective and cognitive processes, have not been completely mapped. We ai...
Gespeichert in:
Hauptverfasser: | , , , , , , , , , , , , |
---|---|
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | |
---|---|
container_issue | |
container_start_page | |
container_title | |
container_volume | |
creator | Boralli Razza, Laís da Silva, Pedro Henrique Rodrigues Busatto, Geraldo F Duran, Fábio Luis de Souza Pereira, Juliana De Smet, Stefanie Klein, Izio Zanão, Tamires A Luethi, Matthias S Baeken, Chris Vanderhasselt, Marie-Anne Buchpiguel, Carlos Alberto Brunoni, André Russowsky |
description | Non-invasive brain stimulation (NIBS) interventions are promising for the treatment of psychiatric disorders. Notwithstanding, the NIBS mechanisms of action over the dorsolateral prefrontal cortex (DLPFC), a hub that modulates affective and cognitive processes, have not been completely mapped. We aimed to investigate regional cerebral blood flow (rCBF) changes over the DLPFC and the subgenual anterior cingulate cortex (sgACC) of different NIBS protocols using Single-Photon Emission Computed Tomography (SPECT). A factorial, within-subjects, double-blinded study was performed. Twenty-three healthy subjects randomly underwent four sessions of NIBS applied once a week: transcranial direct current stimulation (tDCS), intermittent theta-burst stimulation (iTBS), combined tDCS + iTBS and placebo. The radiotracer 99m-Technetium-ethylene-cysteine-dimer was injected intravenously during the NIBS session, and SPECT neuroimages were acquired after the session. Results revealed that the combination of tDCS + iTBS increased right sgACC rCBF. Cathodal and anodal tDCS increased and decreased DLPFC rCBF, respectively, while iTBS showed no significant changes compared to the placebo. Our findings suggest that the combined protocol might optimize the activity in the right sgACC and encourage future trials with neuropsychiatric populations. Moreover, mechanistic studies to investigate the effects of tDCS and iTBS over the DLPFC are required. |
format | Article |
fullrecord | <record><control><sourceid>ghent</sourceid><recordid>TN_cdi_ghent_librecat_oai_archive_ugent_be_8768044</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>oai_archive_ugent_be_8768044</sourcerecordid><originalsourceid>FETCH-ghent_librecat_oai_archive_ugent_be_87680443</originalsourceid><addsrcrecordid>eNqdjUFOw0AMRUeISlTQO_gCkdI0pckWBOIA7EeeidNMNbUrzySCA3BvhooFa7zx0__y841ZN01zqPp639_-4TuzSelUl-m3u27brs3Xk2JguJCOcwrCgDGTYi6YIPAwexrAfULKyANGYYIC4OXsApeKhavAC6awELirK-VwnuNVAbKQQp4IBtEkJSzuCBelUYVzQS-a6ePBrEaMiTa_-940ry_vz2_VcSLONgan5DFbwWBR_VSe2fn4Uzmy3eGxq9t296-jb0GwYy0</addsrcrecordid><sourcetype>Institutional Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Brain perfusion alterations induced by standalone and combined non-invasive brain stimulation over the dorsolateral prefrontal cortex</title><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>Ghent University Academic Bibliography</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Boralli Razza, Laís ; da Silva, Pedro Henrique Rodrigues ; Busatto, Geraldo F ; Duran, Fábio Luis de Souza ; Pereira, Juliana ; De Smet, Stefanie ; Klein, Izio ; Zanão, Tamires A ; Luethi, Matthias S ; Baeken, Chris ; Vanderhasselt, Marie-Anne ; Buchpiguel, Carlos Alberto ; Brunoni, André Russowsky</creator><creatorcontrib>Boralli Razza, Laís ; da Silva, Pedro Henrique Rodrigues ; Busatto, Geraldo F ; Duran, Fábio Luis de Souza ; Pereira, Juliana ; De Smet, Stefanie ; Klein, Izio ; Zanão, Tamires A ; Luethi, Matthias S ; Baeken, Chris ; Vanderhasselt, Marie-Anne ; Buchpiguel, Carlos Alberto ; Brunoni, André Russowsky</creatorcontrib><description>Non-invasive brain stimulation (NIBS) interventions are promising for the treatment of psychiatric disorders. Notwithstanding, the NIBS mechanisms of action over the dorsolateral prefrontal cortex (DLPFC), a hub that modulates affective and cognitive processes, have not been completely mapped. We aimed to investigate regional cerebral blood flow (rCBF) changes over the DLPFC and the subgenual anterior cingulate cortex (sgACC) of different NIBS protocols using Single-Photon Emission Computed Tomography (SPECT). A factorial, within-subjects, double-blinded study was performed. Twenty-three healthy subjects randomly underwent four sessions of NIBS applied once a week: transcranial direct current stimulation (tDCS), intermittent theta-burst stimulation (iTBS), combined tDCS + iTBS and placebo. The radiotracer 99m-Technetium-ethylene-cysteine-dimer was injected intravenously during the NIBS session, and SPECT neuroimages were acquired after the session. Results revealed that the combination of tDCS + iTBS increased right sgACC rCBF. Cathodal and anodal tDCS increased and decreased DLPFC rCBF, respectively, while iTBS showed no significant changes compared to the placebo. Our findings suggest that the combined protocol might optimize the activity in the right sgACC and encourage future trials with neuropsychiatric populations. Moreover, mechanistic studies to investigate the effects of tDCS and iTBS over the DLPFC are required.</description><identifier>ISSN: 2227-9059</identifier><identifier>EISSN: 2227-9059</identifier><language>eng</language><subject>Biology and Life Sciences ; combined interventions ; dorsolateral prefrontal cortex (DLPFC) ; General Biochemistry ; Genetics and Molecular Biology ; Medicine (miscellaneous) ; Medicine and Health Sciences ; neuroimaging ; non-invasive brain stimulation (NIBS) ; Single-Photon Emission Computed Tomography (SPECT) ; synergistic effect</subject><creationdate>2022</creationdate><rights>Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,315,780,784,4024,27860</link.rule.ids></links><search><creatorcontrib>Boralli Razza, Laís</creatorcontrib><creatorcontrib>da Silva, Pedro Henrique Rodrigues</creatorcontrib><creatorcontrib>Busatto, Geraldo F</creatorcontrib><creatorcontrib>Duran, Fábio Luis de Souza</creatorcontrib><creatorcontrib>Pereira, Juliana</creatorcontrib><creatorcontrib>De Smet, Stefanie</creatorcontrib><creatorcontrib>Klein, Izio</creatorcontrib><creatorcontrib>Zanão, Tamires A</creatorcontrib><creatorcontrib>Luethi, Matthias S</creatorcontrib><creatorcontrib>Baeken, Chris</creatorcontrib><creatorcontrib>Vanderhasselt, Marie-Anne</creatorcontrib><creatorcontrib>Buchpiguel, Carlos Alberto</creatorcontrib><creatorcontrib>Brunoni, André Russowsky</creatorcontrib><title>Brain perfusion alterations induced by standalone and combined non-invasive brain stimulation over the dorsolateral prefrontal cortex</title><description>Non-invasive brain stimulation (NIBS) interventions are promising for the treatment of psychiatric disorders. Notwithstanding, the NIBS mechanisms of action over the dorsolateral prefrontal cortex (DLPFC), a hub that modulates affective and cognitive processes, have not been completely mapped. We aimed to investigate regional cerebral blood flow (rCBF) changes over the DLPFC and the subgenual anterior cingulate cortex (sgACC) of different NIBS protocols using Single-Photon Emission Computed Tomography (SPECT). A factorial, within-subjects, double-blinded study was performed. Twenty-three healthy subjects randomly underwent four sessions of NIBS applied once a week: transcranial direct current stimulation (tDCS), intermittent theta-burst stimulation (iTBS), combined tDCS + iTBS and placebo. The radiotracer 99m-Technetium-ethylene-cysteine-dimer was injected intravenously during the NIBS session, and SPECT neuroimages were acquired after the session. Results revealed that the combination of tDCS + iTBS increased right sgACC rCBF. Cathodal and anodal tDCS increased and decreased DLPFC rCBF, respectively, while iTBS showed no significant changes compared to the placebo. Our findings suggest that the combined protocol might optimize the activity in the right sgACC and encourage future trials with neuropsychiatric populations. Moreover, mechanistic studies to investigate the effects of tDCS and iTBS over the DLPFC are required.</description><subject>Biology and Life Sciences</subject><subject>combined interventions</subject><subject>dorsolateral prefrontal cortex (DLPFC)</subject><subject>General Biochemistry</subject><subject>Genetics and Molecular Biology</subject><subject>Medicine (miscellaneous)</subject><subject>Medicine and Health Sciences</subject><subject>neuroimaging</subject><subject>non-invasive brain stimulation (NIBS)</subject><subject>Single-Photon Emission Computed Tomography (SPECT)</subject><subject>synergistic effect</subject><issn>2227-9059</issn><issn>2227-9059</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ADGLB</sourceid><recordid>eNqdjUFOw0AMRUeISlTQO_gCkdI0pckWBOIA7EeeidNMNbUrzySCA3BvhooFa7zx0__y841ZN01zqPp639_-4TuzSelUl-m3u27brs3Xk2JguJCOcwrCgDGTYi6YIPAwexrAfULKyANGYYIC4OXsApeKhavAC6awELirK-VwnuNVAbKQQp4IBtEkJSzuCBelUYVzQS-a6ePBrEaMiTa_-940ry_vz2_VcSLONgan5DFbwWBR_VSe2fn4Uzmy3eGxq9t296-jb0GwYy0</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Boralli Razza, Laís</creator><creator>da Silva, Pedro Henrique Rodrigues</creator><creator>Busatto, Geraldo F</creator><creator>Duran, Fábio Luis de Souza</creator><creator>Pereira, Juliana</creator><creator>De Smet, Stefanie</creator><creator>Klein, Izio</creator><creator>Zanão, Tamires A</creator><creator>Luethi, Matthias S</creator><creator>Baeken, Chris</creator><creator>Vanderhasselt, Marie-Anne</creator><creator>Buchpiguel, Carlos Alberto</creator><creator>Brunoni, André Russowsky</creator><scope>ADGLB</scope></search><sort><creationdate>2022</creationdate><title>Brain perfusion alterations induced by standalone and combined non-invasive brain stimulation over the dorsolateral prefrontal cortex</title><author>Boralli Razza, Laís ; da Silva, Pedro Henrique Rodrigues ; Busatto, Geraldo F ; Duran, Fábio Luis de Souza ; Pereira, Juliana ; De Smet, Stefanie ; Klein, Izio ; Zanão, Tamires A ; Luethi, Matthias S ; Baeken, Chris ; Vanderhasselt, Marie-Anne ; Buchpiguel, Carlos Alberto ; Brunoni, André Russowsky</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-ghent_librecat_oai_archive_ugent_be_87680443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biology and Life Sciences</topic><topic>combined interventions</topic><topic>dorsolateral prefrontal cortex (DLPFC)</topic><topic>General Biochemistry</topic><topic>Genetics and Molecular Biology</topic><topic>Medicine (miscellaneous)</topic><topic>Medicine and Health Sciences</topic><topic>neuroimaging</topic><topic>non-invasive brain stimulation (NIBS)</topic><topic>Single-Photon Emission Computed Tomography (SPECT)</topic><topic>synergistic effect</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boralli Razza, Laís</creatorcontrib><creatorcontrib>da Silva, Pedro Henrique Rodrigues</creatorcontrib><creatorcontrib>Busatto, Geraldo F</creatorcontrib><creatorcontrib>Duran, Fábio Luis de Souza</creatorcontrib><creatorcontrib>Pereira, Juliana</creatorcontrib><creatorcontrib>De Smet, Stefanie</creatorcontrib><creatorcontrib>Klein, Izio</creatorcontrib><creatorcontrib>Zanão, Tamires A</creatorcontrib><creatorcontrib>Luethi, Matthias S</creatorcontrib><creatorcontrib>Baeken, Chris</creatorcontrib><creatorcontrib>Vanderhasselt, Marie-Anne</creatorcontrib><creatorcontrib>Buchpiguel, Carlos Alberto</creatorcontrib><creatorcontrib>Brunoni, André Russowsky</creatorcontrib><collection>Ghent University Academic Bibliography</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boralli Razza, Laís</au><au>da Silva, Pedro Henrique Rodrigues</au><au>Busatto, Geraldo F</au><au>Duran, Fábio Luis de Souza</au><au>Pereira, Juliana</au><au>De Smet, Stefanie</au><au>Klein, Izio</au><au>Zanão, Tamires A</au><au>Luethi, Matthias S</au><au>Baeken, Chris</au><au>Vanderhasselt, Marie-Anne</au><au>Buchpiguel, Carlos Alberto</au><au>Brunoni, André Russowsky</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain perfusion alterations induced by standalone and combined non-invasive brain stimulation over the dorsolateral prefrontal cortex</atitle><date>2022</date><risdate>2022</risdate><issn>2227-9059</issn><eissn>2227-9059</eissn><abstract>Non-invasive brain stimulation (NIBS) interventions are promising for the treatment of psychiatric disorders. Notwithstanding, the NIBS mechanisms of action over the dorsolateral prefrontal cortex (DLPFC), a hub that modulates affective and cognitive processes, have not been completely mapped. We aimed to investigate regional cerebral blood flow (rCBF) changes over the DLPFC and the subgenual anterior cingulate cortex (sgACC) of different NIBS protocols using Single-Photon Emission Computed Tomography (SPECT). A factorial, within-subjects, double-blinded study was performed. Twenty-three healthy subjects randomly underwent four sessions of NIBS applied once a week: transcranial direct current stimulation (tDCS), intermittent theta-burst stimulation (iTBS), combined tDCS + iTBS and placebo. The radiotracer 99m-Technetium-ethylene-cysteine-dimer was injected intravenously during the NIBS session, and SPECT neuroimages were acquired after the session. Results revealed that the combination of tDCS + iTBS increased right sgACC rCBF. Cathodal and anodal tDCS increased and decreased DLPFC rCBF, respectively, while iTBS showed no significant changes compared to the placebo. Our findings suggest that the combined protocol might optimize the activity in the right sgACC and encourage future trials with neuropsychiatric populations. Moreover, mechanistic studies to investigate the effects of tDCS and iTBS over the DLPFC are required.</abstract><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 2227-9059 |
ispartof | |
issn | 2227-9059 2227-9059 |
language | eng |
recordid | cdi_ghent_librecat_oai_archive_ugent_be_8768044 |
source | DOAJ Directory of Open Access Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; Ghent University Academic Bibliography; EZB-FREE-00999 freely available EZB journals; PubMed Central |
subjects | Biology and Life Sciences combined interventions dorsolateral prefrontal cortex (DLPFC) General Biochemistry Genetics and Molecular Biology Medicine (miscellaneous) Medicine and Health Sciences neuroimaging non-invasive brain stimulation (NIBS) Single-Photon Emission Computed Tomography (SPECT) synergistic effect |
title | Brain perfusion alterations induced by standalone and combined non-invasive brain stimulation over the dorsolateral prefrontal cortex |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T00%3A17%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-ghent&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Brain%20perfusion%20alterations%20induced%20by%20standalone%20and%20combined%20non-invasive%20brain%20stimulation%20over%20the%20dorsolateral%20prefrontal%20cortex&rft.au=Boralli%20Razza,%20La%C3%ADs&rft.date=2022&rft.issn=2227-9059&rft.eissn=2227-9059&rft_id=info:doi/&rft_dat=%3Cghent%3Eoai_archive_ugent_be_8768044%3C/ghent%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |