Assessing the dynamic changes in vitiligo : reliability and validity of the Vitiligo Disease Activity Score (VDAS) and Vitiligo Disease Improvement Score (VDIS)
Background The assessment of the individual evolution of vitiligo is important for therapeutic decision making in daily practice. A fast, simple and validated physician-reported score to assess clinical changes in depigmentation over time in separate parts (activity and improvement) is currently mis...
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| creator | van Geel, Nanja Depaepe, L Vandaele, Virginie Mertens, Lotte Van Causenbroeck, J De Schepper, Sofie Van Coile, Laura Van Reempts, Astrid De Vos, Anne-Sophie Papeleu, Jorien Hoorens, Isabelle Mertens, D Wolkerstorfer, A Lommerts, J.E Speeckaert, Reinhart |
| description | Background The assessment of the individual evolution of vitiligo is important for therapeutic decision making in daily practice. A fast, simple and validated physician-reported score to assess clinical changes in depigmentation over time in separate parts (activity and improvement) is currently missing. Objective The main objective of the study was to develop and validate the Vitiligo Disease Activity Score (VDAS) and Vitiligo Disease Improvement Score (VDIS). Methods The Vitiligo Disease Activity Score (VDAS) and Vitiligo Disease Improvement Score (VDIS) were evaluated based on a photo set of 66 patients with two different time points. In the first (short) version, only the number of changing body regions was counted based on 15 predefined areas (VDAS(15) and VDIS15), while in the second (extensive) version the degree of worsening or improvement from +4 to -4 for each body area was added for a more detailed assessment (VDAS(60) and VDIS60). Content and construct validity were tested. In addition inter-, intrarater reliability and feasibility were evaluated by 7 (test) and 5 (retest) physicians. Results Evidence for content and construct validity was provided. Overall, VDAS(15), VDIS15, VDAS(60) and VDIS60 demonstrated good to excellent inter-rater reliability [intraclass correlation (ICC): VDAS: range = 0.797-0.900; VDIS: range = 0.726-0.798]. The intrarater reliability ICCs were 0.865 and 0.781 for the VDAS(15) and VDIS15, respectively. Similar results were obtained for the VDAS(60) and VDIS60 (ICC = 0.913 and 0.800, respectively). Completion time was short (median: 122 s/patient (first round); 95 s/patient (second round)]. Limitations Single tertiary centre mainly of skin phototype 2 to 3. Conclusion The VDAS and VDIS appear to be valid, reliable and feasible instruments to score the evolution of vitiligo lesions. This accommodates the current urgent need for a simple, standardized and practical assessment of vitiligo activity and improvement over time. |
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| fullrecord | <record><control><sourceid>ghent</sourceid><recordid>TN_cdi_ghent_librecat_oai_archive_ugent_be_8757789</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>oai_archive_ugent_be_8757789</sourcerecordid><originalsourceid>FETCH-ghent_librecat_oai_archive_ugent_be_87577893</originalsourceid><addsrcrecordid>eNqdy79OwzAQx3EPILX8eYcb6VApIbQxbBEF0Tmoq3Vxrs4hx0a2sdS34VFpKhADG9Ppp_t8z8S8vFvLZVXIaiYuYnwriqIsV3IuPpsYKUZ2BtJA0B8cjqxBD-gMRWAHmRNbNh4eIJBl7I4rHQBdDxkt99Pw-1O9-6EbjoSRoNGJ8wRa7QPBzW7TtItT-odux_fgM43k0q_etosrcb5HG-n6-16K2-en18eXpRmOVFnuAmlMyiMrDHrgTOrDTK-OlKxXdS3vq39FXzE9Zxc</addsrcrecordid><sourcetype>Institutional Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Assessing the dynamic changes in vitiligo : reliability and validity of the Vitiligo Disease Activity Score (VDAS) and Vitiligo Disease Improvement Score (VDIS)</title><source>Ghent University Academic Bibliography</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>van Geel, Nanja ; Depaepe, L ; Vandaele, Virginie ; Mertens, Lotte ; Van Causenbroeck, J ; De Schepper, Sofie ; Van Coile, Laura ; Van Reempts, Astrid ; De Vos, Anne-Sophie ; Papeleu, Jorien ; Hoorens, Isabelle ; Mertens, D ; Wolkerstorfer, A ; Lommerts, J.E ; Speeckaert, Reinhart</creator><creatorcontrib>van Geel, Nanja ; Depaepe, L ; Vandaele, Virginie ; Mertens, Lotte ; Van Causenbroeck, J ; De Schepper, Sofie ; Van Coile, Laura ; Van Reempts, Astrid ; De Vos, Anne-Sophie ; Papeleu, Jorien ; Hoorens, Isabelle ; Mertens, D ; Wolkerstorfer, A ; Lommerts, J.E ; Speeckaert, Reinhart</creatorcontrib><description>Background The assessment of the individual evolution of vitiligo is important for therapeutic decision making in daily practice. A fast, simple and validated physician-reported score to assess clinical changes in depigmentation over time in separate parts (activity and improvement) is currently missing. Objective The main objective of the study was to develop and validate the Vitiligo Disease Activity Score (VDAS) and Vitiligo Disease Improvement Score (VDIS). Methods The Vitiligo Disease Activity Score (VDAS) and Vitiligo Disease Improvement Score (VDIS) were evaluated based on a photo set of 66 patients with two different time points. In the first (short) version, only the number of changing body regions was counted based on 15 predefined areas (VDAS(15) and VDIS15), while in the second (extensive) version the degree of worsening or improvement from +4 to -4 for each body area was added for a more detailed assessment (VDAS(60) and VDIS60). Content and construct validity were tested. In addition inter-, intrarater reliability and feasibility were evaluated by 7 (test) and 5 (retest) physicians. Results Evidence for content and construct validity was provided. Overall, VDAS(15), VDIS15, VDAS(60) and VDIS60 demonstrated good to excellent inter-rater reliability [intraclass correlation (ICC): VDAS: range = 0.797-0.900; VDIS: range = 0.726-0.798]. The intrarater reliability ICCs were 0.865 and 0.781 for the VDAS(15) and VDIS15, respectively. Similar results were obtained for the VDAS(60) and VDIS60 (ICC = 0.913 and 0.800, respectively). Completion time was short (median: 122 s/patient (first round); 95 s/patient (second round)]. Limitations Single tertiary centre mainly of skin phototype 2 to 3. Conclusion The VDAS and VDIS appear to be valid, reliable and feasible instruments to score the evolution of vitiligo lesions. This accommodates the current urgent need for a simple, standardized and practical assessment of vitiligo activity and improvement over time.</description><identifier>ISSN: 1468-3083</identifier><identifier>ISSN: 0926-9959</identifier><language>eng</language><subject>Dermatology ; Infectious Diseases ; Medicine and Health Sciences ; VALIDATION</subject><creationdate>2022</creationdate><rights>Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Public License (CC BY-NC-ND 4.0) info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,315,776,780,4010,27837</link.rule.ids></links><search><creatorcontrib>van Geel, Nanja</creatorcontrib><creatorcontrib>Depaepe, L</creatorcontrib><creatorcontrib>Vandaele, Virginie</creatorcontrib><creatorcontrib>Mertens, Lotte</creatorcontrib><creatorcontrib>Van Causenbroeck, J</creatorcontrib><creatorcontrib>De Schepper, Sofie</creatorcontrib><creatorcontrib>Van Coile, Laura</creatorcontrib><creatorcontrib>Van Reempts, Astrid</creatorcontrib><creatorcontrib>De Vos, Anne-Sophie</creatorcontrib><creatorcontrib>Papeleu, Jorien</creatorcontrib><creatorcontrib>Hoorens, Isabelle</creatorcontrib><creatorcontrib>Mertens, D</creatorcontrib><creatorcontrib>Wolkerstorfer, A</creatorcontrib><creatorcontrib>Lommerts, J.E</creatorcontrib><creatorcontrib>Speeckaert, Reinhart</creatorcontrib><title>Assessing the dynamic changes in vitiligo : reliability and validity of the Vitiligo Disease Activity Score (VDAS) and Vitiligo Disease Improvement Score (VDIS)</title><description>Background The assessment of the individual evolution of vitiligo is important for therapeutic decision making in daily practice. A fast, simple and validated physician-reported score to assess clinical changes in depigmentation over time in separate parts (activity and improvement) is currently missing. Objective The main objective of the study was to develop and validate the Vitiligo Disease Activity Score (VDAS) and Vitiligo Disease Improvement Score (VDIS). Methods The Vitiligo Disease Activity Score (VDAS) and Vitiligo Disease Improvement Score (VDIS) were evaluated based on a photo set of 66 patients with two different time points. In the first (short) version, only the number of changing body regions was counted based on 15 predefined areas (VDAS(15) and VDIS15), while in the second (extensive) version the degree of worsening or improvement from +4 to -4 for each body area was added for a more detailed assessment (VDAS(60) and VDIS60). Content and construct validity were tested. In addition inter-, intrarater reliability and feasibility were evaluated by 7 (test) and 5 (retest) physicians. Results Evidence for content and construct validity was provided. Overall, VDAS(15), VDIS15, VDAS(60) and VDIS60 demonstrated good to excellent inter-rater reliability [intraclass correlation (ICC): VDAS: range = 0.797-0.900; VDIS: range = 0.726-0.798]. The intrarater reliability ICCs were 0.865 and 0.781 for the VDAS(15) and VDIS15, respectively. Similar results were obtained for the VDAS(60) and VDIS60 (ICC = 0.913 and 0.800, respectively). Completion time was short (median: 122 s/patient (first round); 95 s/patient (second round)]. Limitations Single tertiary centre mainly of skin phototype 2 to 3. Conclusion The VDAS and VDIS appear to be valid, reliable and feasible instruments to score the evolution of vitiligo lesions. This accommodates the current urgent need for a simple, standardized and practical assessment of vitiligo activity and improvement over time.</description><subject>Dermatology</subject><subject>Infectious Diseases</subject><subject>Medicine and Health Sciences</subject><subject>VALIDATION</subject><issn>1468-3083</issn><issn>0926-9959</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ADGLB</sourceid><recordid>eNqdy79OwzAQx3EPILX8eYcb6VApIbQxbBEF0Tmoq3Vxrs4hx0a2sdS34VFpKhADG9Ppp_t8z8S8vFvLZVXIaiYuYnwriqIsV3IuPpsYKUZ2BtJA0B8cjqxBD-gMRWAHmRNbNh4eIJBl7I4rHQBdDxkt99Pw-1O9-6EbjoSRoNGJ8wRa7QPBzW7TtItT-odux_fgM43k0q_etosrcb5HG-n6-16K2-en18eXpRmOVFnuAmlMyiMrDHrgTOrDTK-OlKxXdS3vq39FXzE9Zxc</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>van Geel, Nanja</creator><creator>Depaepe, L</creator><creator>Vandaele, Virginie</creator><creator>Mertens, Lotte</creator><creator>Van Causenbroeck, J</creator><creator>De Schepper, Sofie</creator><creator>Van Coile, Laura</creator><creator>Van Reempts, Astrid</creator><creator>De Vos, Anne-Sophie</creator><creator>Papeleu, Jorien</creator><creator>Hoorens, Isabelle</creator><creator>Mertens, D</creator><creator>Wolkerstorfer, A</creator><creator>Lommerts, J.E</creator><creator>Speeckaert, Reinhart</creator><scope>ADGLB</scope></search><sort><creationdate>2022</creationdate><title>Assessing the dynamic changes in vitiligo : reliability and validity of the Vitiligo Disease Activity Score (VDAS) and Vitiligo Disease Improvement Score (VDIS)</title><author>van Geel, Nanja ; Depaepe, L ; Vandaele, Virginie ; Mertens, Lotte ; Van Causenbroeck, J ; De Schepper, Sofie ; Van Coile, Laura ; Van Reempts, Astrid ; De Vos, Anne-Sophie ; Papeleu, Jorien ; Hoorens, Isabelle ; Mertens, D ; Wolkerstorfer, A ; Lommerts, J.E ; Speeckaert, Reinhart</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-ghent_librecat_oai_archive_ugent_be_87577893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Dermatology</topic><topic>Infectious Diseases</topic><topic>Medicine and Health Sciences</topic><topic>VALIDATION</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Geel, Nanja</creatorcontrib><creatorcontrib>Depaepe, L</creatorcontrib><creatorcontrib>Vandaele, Virginie</creatorcontrib><creatorcontrib>Mertens, Lotte</creatorcontrib><creatorcontrib>Van Causenbroeck, J</creatorcontrib><creatorcontrib>De Schepper, Sofie</creatorcontrib><creatorcontrib>Van Coile, Laura</creatorcontrib><creatorcontrib>Van Reempts, Astrid</creatorcontrib><creatorcontrib>De Vos, Anne-Sophie</creatorcontrib><creatorcontrib>Papeleu, Jorien</creatorcontrib><creatorcontrib>Hoorens, Isabelle</creatorcontrib><creatorcontrib>Mertens, D</creatorcontrib><creatorcontrib>Wolkerstorfer, A</creatorcontrib><creatorcontrib>Lommerts, J.E</creatorcontrib><creatorcontrib>Speeckaert, Reinhart</creatorcontrib><collection>Ghent University Academic Bibliography</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Geel, Nanja</au><au>Depaepe, L</au><au>Vandaele, Virginie</au><au>Mertens, Lotte</au><au>Van Causenbroeck, J</au><au>De Schepper, Sofie</au><au>Van Coile, Laura</au><au>Van Reempts, Astrid</au><au>De Vos, Anne-Sophie</au><au>Papeleu, Jorien</au><au>Hoorens, Isabelle</au><au>Mertens, D</au><au>Wolkerstorfer, A</au><au>Lommerts, J.E</au><au>Speeckaert, Reinhart</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessing the dynamic changes in vitiligo : reliability and validity of the Vitiligo Disease Activity Score (VDAS) and Vitiligo Disease Improvement Score (VDIS)</atitle><date>2022</date><risdate>2022</risdate><issn>1468-3083</issn><issn>0926-9959</issn><abstract>Background The assessment of the individual evolution of vitiligo is important for therapeutic decision making in daily practice. A fast, simple and validated physician-reported score to assess clinical changes in depigmentation over time in separate parts (activity and improvement) is currently missing. Objective The main objective of the study was to develop and validate the Vitiligo Disease Activity Score (VDAS) and Vitiligo Disease Improvement Score (VDIS). Methods The Vitiligo Disease Activity Score (VDAS) and Vitiligo Disease Improvement Score (VDIS) were evaluated based on a photo set of 66 patients with two different time points. In the first (short) version, only the number of changing body regions was counted based on 15 predefined areas (VDAS(15) and VDIS15), while in the second (extensive) version the degree of worsening or improvement from +4 to -4 for each body area was added for a more detailed assessment (VDAS(60) and VDIS60). Content and construct validity were tested. In addition inter-, intrarater reliability and feasibility were evaluated by 7 (test) and 5 (retest) physicians. Results Evidence for content and construct validity was provided. Overall, VDAS(15), VDIS15, VDAS(60) and VDIS60 demonstrated good to excellent inter-rater reliability [intraclass correlation (ICC): VDAS: range = 0.797-0.900; VDIS: range = 0.726-0.798]. The intrarater reliability ICCs were 0.865 and 0.781 for the VDAS(15) and VDIS15, respectively. Similar results were obtained for the VDAS(60) and VDIS60 (ICC = 0.913 and 0.800, respectively). Completion time was short (median: 122 s/patient (first round); 95 s/patient (second round)]. Limitations Single tertiary centre mainly of skin phototype 2 to 3. Conclusion The VDAS and VDIS appear to be valid, reliable and feasible instruments to score the evolution of vitiligo lesions. This accommodates the current urgent need for a simple, standardized and practical assessment of vitiligo activity and improvement over time.</abstract><oa>free_for_read</oa></addata></record> |
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| title | Assessing the dynamic changes in vitiligo : reliability and validity of the Vitiligo Disease Activity Score (VDAS) and Vitiligo Disease Improvement Score (VDIS) |
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