Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis

Genome-wide association studies and follow-up meta-analyses in Crohn's disease (CD) and ulcerative colitis (UC) have recently identified 163 disease-associated loci that meet genome-wide significance for these two inflammatory bowel diseases (IBD). These discoveries have already had a tremendou...

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Hauptverfasser:	Beaudoin, Mélissa, Goyette, Philippe, Boucher, Gabrielle, Lo, Ken Sin, Rivas, Manuel A, Stevens, Christine, Alikashani, Azadeh, Ladouceur, Martin, Ellinghaus, David, Törkvist, Leif, Goel, Gautam, Lagacé, Caroline, Annese, Vito, Bitton, Alain, Begun, Jakob, Brant, Steve R, Bresso, Francesca, Cho, Judy H, Duerr, Richard H, Halfvarson, Jonas, McGovern, Dermot P. B, Radford-Smith, Graham, Schreiber, Stefan, Schumm, Philip L, Sharma, Yashoda, Silverberg, Mark S, Weersma, Rinse K, D'Amato, Mauro, Vermeire, Severine, Franke, Andre, Lettre, Guillaume, Xavier, Ramnik J, Daly, Mark J, Rioux, John D, Laukens, Debby, Quebec IBD Genetics Consortium, [missing], NIDDK IBD Genetics Consortium, [missing], International IBD Genetics Consortium, [missing]
Format:	Artikel
Sprache:	eng
Schlagworte:	Behavior and Systematics Cancer Research CELLS CROHN-DISEASE Ecology Evolution EXPRESSION GENETIC-VARIANTS Genetics Genetics(clinical) GENOME-WIDE ASSOCIATION INFLAMMATORY-BOWEL-DISEASE Medicine and Health Sciences MODULATION Molecular Biology NUCLEAR FACTOR 4-ALPHA SUSCEPTIBILITY LOCI UBIQUITIN LIGASES
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