New paradigm in NKT cell antigens : MCS-0208 (2-(hydroxymethyl)phenylthio-phytoceramide) - an aryl-phytoceramide compound with a single hydroxyl group stimulates NKT cells

Natural Killer T (NKT) cells play an important role in the immune response and can be activated by glycolipids presented by CD1d protein. We present MCS-0208, an unprecedented arylthioether-phytoceramide able to induce potent invariant NKT (iNKT) cell activation, notably when tested in human iNKT ce...

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Hauptverfasser:	Borras-Tuduri, Roser, Alcaide, Anna, ASPESLAGH, SANDRINE, Usero, Lorena, Serra, Carmen, Roura-Mir, Carme, Elewaut, Dirk, Llebaria, Amadeu
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTIVATION alfa-galactosylceramide ANALOGS aryl-ceramide Biology and Life Sciences DISCOVERY GLYCOLIPIDS immunostimulation KILLER T-CELLS Medicine and Health Sciences NKT cells RESIDUES
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