Gut-skin axis : current knowledge of the interrelationship between microbial dysbiosis and skin conditions
The microbiome plays an important role in a wide variety of skin disorders. Not only is the skin microbiome altered, but also surprisingly many skin diseases are accompanied by an altered gut microbiome. The microbiome is a key regulator for the immune system, as it aims to maintain homeostasis by c...
Gespeichert in:
Hauptverfasser: | , , , , , |
---|---|
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | |
---|---|
container_issue | |
container_start_page | |
container_title | |
container_volume | |
creator | De Pessemier, Britta Grine, Lynda Debaere, Melanie Maes, Aglaya Paetzold, Bernhard Callewaert, Chris |
description | The microbiome plays an important role in a wide variety of skin disorders. Not only is the skin microbiome altered, but also surprisingly many skin diseases are accompanied by an altered gut microbiome. The microbiome is a key regulator for the immune system, as it aims to maintain homeostasis by communicating with tissues and organs in a bidirectional manner. Hence, dysbiosis in the skin and/or gut microbiome is associated with an altered immune response, promoting the development of skin diseases, such as atopic dermatitis, psoriasis, acne vulgaris, dandruff, and even skin cancer. Here, we focus on the associations between the microbiome, diet, metabolites, and immune responses in skin pathologies. This review describes an exhaustive list of common skin conditions with associated dysbiosis in the skin microbiome as well as the current body of evidence on gut microbiome dysbiosis, dietary links, and their interplay with skin conditions. An enhanced understanding of the local skin and gut microbiome including the underlying mechanisms is necessary to shed light on the microbial involvement in human skin diseases and to develop new therapeutic approaches. |
format | Article |
fullrecord | <record><control><sourceid>ghent</sourceid><recordid>TN_cdi_ghent_librecat_oai_archive_ugent_be_8701391</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>oai_archive_ugent_be_8701391</sourcerecordid><originalsourceid>FETCH-ghent_librecat_oai_archive_ugent_be_87013913</originalsourceid><addsrcrecordid>eNqdTksKwjAUDKKgqHd4Fyi0FW11K34O4D4k6Wv7bEwkSf3c3iguXDubGRjmM2CTPC1WSb5Ki-GPHrO59-c0Yp0tymU2YedDHxLfkQHxIA8bUL1zaAJ0xt41Vg2CrSG0CGQCRkuLQNb4lq4gMdwRDVxIOStJaKieXpL1sUiYCj61ypqKPpEZG9VCe5x_ecry_e60PSZNGwe5JulQicCtIC6caumGvG_elkReFmm2iKf_Cr0AI51YHg</addsrcrecordid><sourcetype>Institutional Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Gut-skin axis : current knowledge of the interrelationship between microbial dysbiosis and skin conditions</title><source>PubMed Central(OpenAccess)</source><source>Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>Ghent University Academic Bibliography</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>De Pessemier, Britta ; Grine, Lynda ; Debaere, Melanie ; Maes, Aglaya ; Paetzold, Bernhard ; Callewaert, Chris</creator><creatorcontrib>De Pessemier, Britta ; Grine, Lynda ; Debaere, Melanie ; Maes, Aglaya ; Paetzold, Bernhard ; Callewaert, Chris</creatorcontrib><description>The microbiome plays an important role in a wide variety of skin disorders. Not only is the skin microbiome altered, but also surprisingly many skin diseases are accompanied by an altered gut microbiome. The microbiome is a key regulator for the immune system, as it aims to maintain homeostasis by communicating with tissues and organs in a bidirectional manner. Hence, dysbiosis in the skin and/or gut microbiome is associated with an altered immune response, promoting the development of skin diseases, such as atopic dermatitis, psoriasis, acne vulgaris, dandruff, and even skin cancer. Here, we focus on the associations between the microbiome, diet, metabolites, and immune responses in skin pathologies. This review describes an exhaustive list of common skin conditions with associated dysbiosis in the skin microbiome as well as the current body of evidence on gut microbiome dysbiosis, dietary links, and their interplay with skin conditions. An enhanced understanding of the local skin and gut microbiome including the underlying mechanisms is necessary to shed light on the microbial involvement in human skin diseases and to develop new therapeutic approaches.</description><identifier>ISSN: 2076-2607</identifier><identifier>EISSN: 2076-2607</identifier><language>eng</language><subject>acne vulgaris ; atopic dermatitis ; dandruff ; dietary ; gut dysbiosis ; Medicine and Health Sciences ; probiotics ; psoriasis ; rosacea ; skin cancer ; skin microbiome ; wound healing</subject><creationdate>2021</creationdate><rights>Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,315,780,784,4024,27860</link.rule.ids></links><search><creatorcontrib>De Pessemier, Britta</creatorcontrib><creatorcontrib>Grine, Lynda</creatorcontrib><creatorcontrib>Debaere, Melanie</creatorcontrib><creatorcontrib>Maes, Aglaya</creatorcontrib><creatorcontrib>Paetzold, Bernhard</creatorcontrib><creatorcontrib>Callewaert, Chris</creatorcontrib><title>Gut-skin axis : current knowledge of the interrelationship between microbial dysbiosis and skin conditions</title><description>The microbiome plays an important role in a wide variety of skin disorders. Not only is the skin microbiome altered, but also surprisingly many skin diseases are accompanied by an altered gut microbiome. The microbiome is a key regulator for the immune system, as it aims to maintain homeostasis by communicating with tissues and organs in a bidirectional manner. Hence, dysbiosis in the skin and/or gut microbiome is associated with an altered immune response, promoting the development of skin diseases, such as atopic dermatitis, psoriasis, acne vulgaris, dandruff, and even skin cancer. Here, we focus on the associations between the microbiome, diet, metabolites, and immune responses in skin pathologies. This review describes an exhaustive list of common skin conditions with associated dysbiosis in the skin microbiome as well as the current body of evidence on gut microbiome dysbiosis, dietary links, and their interplay with skin conditions. An enhanced understanding of the local skin and gut microbiome including the underlying mechanisms is necessary to shed light on the microbial involvement in human skin diseases and to develop new therapeutic approaches.</description><subject>acne vulgaris</subject><subject>atopic dermatitis</subject><subject>dandruff</subject><subject>dietary</subject><subject>gut dysbiosis</subject><subject>Medicine and Health Sciences</subject><subject>probiotics</subject><subject>psoriasis</subject><subject>rosacea</subject><subject>skin cancer</subject><subject>skin microbiome</subject><subject>wound healing</subject><issn>2076-2607</issn><issn>2076-2607</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ADGLB</sourceid><recordid>eNqdTksKwjAUDKKgqHd4Fyi0FW11K34O4D4k6Wv7bEwkSf3c3iguXDubGRjmM2CTPC1WSb5Ki-GPHrO59-c0Yp0tymU2YedDHxLfkQHxIA8bUL1zaAJ0xt41Vg2CrSG0CGQCRkuLQNb4lq4gMdwRDVxIOStJaKieXpL1sUiYCj61ypqKPpEZG9VCe5x_ecry_e60PSZNGwe5JulQicCtIC6caumGvG_elkReFmm2iKf_Cr0AI51YHg</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>De Pessemier, Britta</creator><creator>Grine, Lynda</creator><creator>Debaere, Melanie</creator><creator>Maes, Aglaya</creator><creator>Paetzold, Bernhard</creator><creator>Callewaert, Chris</creator><scope>ADGLB</scope></search><sort><creationdate>2021</creationdate><title>Gut-skin axis : current knowledge of the interrelationship between microbial dysbiosis and skin conditions</title><author>De Pessemier, Britta ; Grine, Lynda ; Debaere, Melanie ; Maes, Aglaya ; Paetzold, Bernhard ; Callewaert, Chris</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-ghent_librecat_oai_archive_ugent_be_87013913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>acne vulgaris</topic><topic>atopic dermatitis</topic><topic>dandruff</topic><topic>dietary</topic><topic>gut dysbiosis</topic><topic>Medicine and Health Sciences</topic><topic>probiotics</topic><topic>psoriasis</topic><topic>rosacea</topic><topic>skin cancer</topic><topic>skin microbiome</topic><topic>wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Pessemier, Britta</creatorcontrib><creatorcontrib>Grine, Lynda</creatorcontrib><creatorcontrib>Debaere, Melanie</creatorcontrib><creatorcontrib>Maes, Aglaya</creatorcontrib><creatorcontrib>Paetzold, Bernhard</creatorcontrib><creatorcontrib>Callewaert, Chris</creatorcontrib><collection>Ghent University Academic Bibliography</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Pessemier, Britta</au><au>Grine, Lynda</au><au>Debaere, Melanie</au><au>Maes, Aglaya</au><au>Paetzold, Bernhard</au><au>Callewaert, Chris</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gut-skin axis : current knowledge of the interrelationship between microbial dysbiosis and skin conditions</atitle><date>2021</date><risdate>2021</risdate><issn>2076-2607</issn><eissn>2076-2607</eissn><abstract>The microbiome plays an important role in a wide variety of skin disorders. Not only is the skin microbiome altered, but also surprisingly many skin diseases are accompanied by an altered gut microbiome. The microbiome is a key regulator for the immune system, as it aims to maintain homeostasis by communicating with tissues and organs in a bidirectional manner. Hence, dysbiosis in the skin and/or gut microbiome is associated with an altered immune response, promoting the development of skin diseases, such as atopic dermatitis, psoriasis, acne vulgaris, dandruff, and even skin cancer. Here, we focus on the associations between the microbiome, diet, metabolites, and immune responses in skin pathologies. This review describes an exhaustive list of common skin conditions with associated dysbiosis in the skin microbiome as well as the current body of evidence on gut microbiome dysbiosis, dietary links, and their interplay with skin conditions. An enhanced understanding of the local skin and gut microbiome including the underlying mechanisms is necessary to shed light on the microbial involvement in human skin diseases and to develop new therapeutic approaches.</abstract><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 2076-2607 |
ispartof | |
issn | 2076-2607 2076-2607 |
language | eng |
recordid | cdi_ghent_librecat_oai_archive_ugent_be_8701391 |
source | PubMed Central(OpenAccess); Directory of Open Access Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; Ghent University Academic Bibliography; EZB-FREE-00999 freely available EZB journals |
subjects | acne vulgaris atopic dermatitis dandruff dietary gut dysbiosis Medicine and Health Sciences probiotics psoriasis rosacea skin cancer skin microbiome wound healing |
title | Gut-skin axis : current knowledge of the interrelationship between microbial dysbiosis and skin conditions |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T07%3A21%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-ghent&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gut-skin%20axis%20:%20current%20knowledge%20of%20the%20interrelationship%20between%20microbial%20dysbiosis%20and%20skin%20conditions&rft.au=De%20Pessemier,%20Britta&rft.date=2021&rft.issn=2076-2607&rft.eissn=2076-2607&rft_id=info:doi/&rft_dat=%3Cghent%3Eoai_archive_ugent_be_8701391%3C/ghent%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |