Chimeric antigen receptor-T cells for targeting solid tumors : current challenges and existing strategies

Chimeric antigen receptor-T cells (CAR-Ts) are an exciting new cancer treatment modality exemplified by the recent regulatory approval of two CD19-targeted CAR-T therapies for certain B cell malignancies. However, this success in the hematological setting has yet to translate to a significant level...

Ausführliche Beschreibung

Bibliographische Detailangaben

Hauptverfasser:	Springuel, Lorraine, Lonez, Caroline, Alexandre, Bertrand, Van Cutsem, Eric, Machiels, Jean-Pascal H, Van Den Eynde, Marc, Prenen, Hans, Hendlisz, Alain, Shaza, Leila, Carrasco, Javier, Canon, Jean-Luc, Opyrchal, Mateusz, Odunsi, Kunle, Rottey, Sylvie, Gilham, David E, Flament, Anne, Lehmann, Frederic F
Format:	Artikel
Sprache:	eng
Schlagworte:	ADOPTIVE IMMUNOTHERAPY ANTITUMOR-ACTIVITY BLOCKADE CANCER CHECKPOINT DOSE-ESCALATION EXPRESSION GENE LYMPHOCYTES Medicine and Health Sciences PHASE-I THERAPY
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!