CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis

Retinoblastoma is a pediatric eye tumor in which bi-allelic inactivation of the Retinoblastoma 1 (RB1) gene is the initiating genetic lesion. Although recently curative rates of retinoblastoma have increased, there are at this time no molecular targeted therapies available. This is, in part, due to...

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Hauptverfasser:	Naert, Thomas, Colpaert, Robin, Van Nieuwenhuysen, Tom, Dimitrakopoulou, Dionysia, L, J, Haustraete, Jurgen, Boel, Annekatrien, Steyaert, Wouter, Lepez, Trees, Deforce, Dieter, Willaert, Andy, Creytens, David, Vleminckx, Kris
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences DEFICIENT EXPRESSION GENE GENOME HEMATOPOIESIS MANAGEMENT MICE PRECLINICAL MODELS TRILATERAL RETINOBLASTOMA ZEBRAFISH
Online-Zugang:	Volltext
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