Crystal structures of bovine CD1d reveal altered αGalCer presentation and a restricted A' pocket unable to bind long-chain glycolipids

NKT cells play important roles in immune surveillance. They rapidly respond to pathogens by detecting microbial glycolipids when presented by the non-classical MHC I homolog CD1d. Previously, ruminants were considered to lack NKT cells due to the lack of a functional CD1D gene. However, recent data...

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Bibliographische Detailangaben

Hauptverfasser:	Wang, Jing, Guillaume, Joren, Pauwels, Nora, Van Calenbergh, Serge, Van Rhijn, Ildiko, Zajonc, Dirk M
Format:	Artikel
Sprache:	eng
Schlagworte:	ANTIGEN PRESENTATION AUTOIMMUNITY Biology and Life Sciences FAMILY NKT CELLS PROTEINS RECOGNITION SULFATIDE T-CELL-RECEPTOR
Online-Zugang:	Volltext
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