Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies
Fluorescence in situ hybridization was performed to characterize 81 cases of myeloid and lymphoid malignancies with cytogenetic 1p36 alterations not affecting the PRDM16 locus. In total, three subgroups were identified: balanced translocations (N = 27) and telomeric rearrangements (N = 15), both mai...
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| creator | Duhoux, François P Ameye, Geneviève Lambot, Virginie Herens, Christian Lambert, Frédéric Raynaud, Sophie Wlodarska, Iwona Michaux, Lucienne Roche-Lestienne, Catherine Labis, Elise Taviaux, Sylvie Chapiro, Elise Nguyen-Khac, Florence Struski, Stéphanie Dobbelstein, Sophie Dastugue, Nicole Lippert, Eric Speleman, Franki Van Roy, Nadine De Weer, An Rack, Katrina Talmant, Pascaline Richebourg, Steven Mugneret, Francine Tigaud, Isabelle Mozziconacci, Marie-Joëlle Laibe, Sophy Nadal, Nathalie Terré, Christine Libouton, Jeanne-Marie Decottignies, Anabelle Vikkula, Miikka Poirel, Hélène A |
| description | Fluorescence in situ hybridization was performed to characterize 81 cases of myeloid and lymphoid malignancies with cytogenetic 1p36 alterations not affecting the PRDM16 locus. In total, three subgroups were identified: balanced translocations (N = 27) and telomeric rearrangements (N = 15), both mainly observed in myeloid disorders; and unbalanced non-telomeric rearrangements (N = 39), mainly observed in lymphoid proliferations and frequently associated with a highly complex karyotype. The 1p36 rearrangement was isolated in 12 cases, mainly myeloid disorders. The breakpoints on 1p36 were more widely distributed than previously reported, but with identifiable rare breakpoint cluster regions, such as the TP73 locus. We also found novel partner loci on 1p36 for the known multi-partner genes HMGA2 and RUNX1. We precised the common terminal 1p36 deletion, which has been suggested to have an adverse prognosis, in B-cell lymphomas [follicular lymphomas and diffuse large B-cell lymphomas with t(14;18)(q32;q21) as well as follicular lymphomas without t(14;18)]. Intrachromosomal telomeric repetitive sequences were detected in at least half the cases of telomeric rearrangements. It is unclear how the latter rearrangements occurred and whether they represent oncogenic events or result from chromosomal instability during oncogenesis. |
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In total, three subgroups were identified: balanced translocations (N = 27) and telomeric rearrangements (N = 15), both mainly observed in myeloid disorders; and unbalanced non-telomeric rearrangements (N = 39), mainly observed in lymphoid proliferations and frequently associated with a highly complex karyotype. The 1p36 rearrangement was isolated in 12 cases, mainly myeloid disorders. The breakpoints on 1p36 were more widely distributed than previously reported, but with identifiable rare breakpoint cluster regions, such as the TP73 locus. We also found novel partner loci on 1p36 for the known multi-partner genes HMGA2 and RUNX1. We precised the common terminal 1p36 deletion, which has been suggested to have an adverse prognosis, in B-cell lymphomas [follicular lymphomas and diffuse large B-cell lymphomas with t(14;18)(q32;q21) as well as follicular lymphomas without t(14;18)]. Intrachromosomal telomeric repetitive sequences were detected in at least half the cases of telomeric rearrangements. It is unclear how the latter rearrangements occurred and whether they represent oncogenic events or result from chromosomal instability during oncogenesis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><language>eng</language><subject>Biology and Life Sciences ; CHROMOSOMAL TRANSLOCATIONS ; CHRONIC LYMPHOCYTIC-LEUKEMIA ; COPY NUMBER ; CYTOGENETIC ANALYSIS ; FOLLICULAR LYMPHOMA ; IN-SITU HYBRIDIZATION ; MYELODYSPLASTIC SYNDROME ; NEUROBLASTOMA ; NON-HODGKINS-LYMPHOMAS ; TUMOR-SUPPRESSOR GENE</subject><creationdate>2011</creationdate><rights>No license (in copyright) info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,315,776,780,4010,27837</link.rule.ids></links><search><creatorcontrib>Duhoux, François P</creatorcontrib><creatorcontrib>Ameye, Geneviève</creatorcontrib><creatorcontrib>Lambot, Virginie</creatorcontrib><creatorcontrib>Herens, Christian</creatorcontrib><creatorcontrib>Lambert, Frédéric</creatorcontrib><creatorcontrib>Raynaud, Sophie</creatorcontrib><creatorcontrib>Wlodarska, Iwona</creatorcontrib><creatorcontrib>Michaux, Lucienne</creatorcontrib><creatorcontrib>Roche-Lestienne, Catherine</creatorcontrib><creatorcontrib>Labis, Elise</creatorcontrib><creatorcontrib>Taviaux, Sylvie</creatorcontrib><creatorcontrib>Chapiro, Elise</creatorcontrib><creatorcontrib>Nguyen-Khac, Florence</creatorcontrib><creatorcontrib>Struski, Stéphanie</creatorcontrib><creatorcontrib>Dobbelstein, Sophie</creatorcontrib><creatorcontrib>Dastugue, Nicole</creatorcontrib><creatorcontrib>Lippert, Eric</creatorcontrib><creatorcontrib>Speleman, Franki</creatorcontrib><creatorcontrib>Van Roy, Nadine</creatorcontrib><creatorcontrib>De Weer, An</creatorcontrib><creatorcontrib>Rack, Katrina</creatorcontrib><creatorcontrib>Talmant, Pascaline</creatorcontrib><creatorcontrib>Richebourg, Steven</creatorcontrib><creatorcontrib>Mugneret, Francine</creatorcontrib><creatorcontrib>Tigaud, Isabelle</creatorcontrib><creatorcontrib>Mozziconacci, Marie-Joëlle</creatorcontrib><creatorcontrib>Laibe, Sophy</creatorcontrib><creatorcontrib>Nadal, Nathalie</creatorcontrib><creatorcontrib>Terré, Christine</creatorcontrib><creatorcontrib>Libouton, Jeanne-Marie</creatorcontrib><creatorcontrib>Decottignies, Anabelle</creatorcontrib><creatorcontrib>Vikkula, Miikka</creatorcontrib><creatorcontrib>Poirel, Hélène A</creatorcontrib><title>Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies</title><description>Fluorescence in situ hybridization was performed to characterize 81 cases of myeloid and lymphoid malignancies with cytogenetic 1p36 alterations not affecting the PRDM16 locus. In total, three subgroups were identified: balanced translocations (N = 27) and telomeric rearrangements (N = 15), both mainly observed in myeloid disorders; and unbalanced non-telomeric rearrangements (N = 39), mainly observed in lymphoid proliferations and frequently associated with a highly complex karyotype. The 1p36 rearrangement was isolated in 12 cases, mainly myeloid disorders. The breakpoints on 1p36 were more widely distributed than previously reported, but with identifiable rare breakpoint cluster regions, such as the TP73 locus. We also found novel partner loci on 1p36 for the known multi-partner genes HMGA2 and RUNX1. We precised the common terminal 1p36 deletion, which has been suggested to have an adverse prognosis, in B-cell lymphomas [follicular lymphomas and diffuse large B-cell lymphomas with t(14;18)(q32;q21) as well as follicular lymphomas without t(14;18)]. Intrachromosomal telomeric repetitive sequences were detected in at least half the cases of telomeric rearrangements. It is unclear how the latter rearrangements occurred and whether they represent oncogenic events or result from chromosomal instability during oncogenesis.</description><subject>Biology and Life Sciences</subject><subject>CHROMOSOMAL TRANSLOCATIONS</subject><subject>CHRONIC LYMPHOCYTIC-LEUKEMIA</subject><subject>COPY NUMBER</subject><subject>CYTOGENETIC ANALYSIS</subject><subject>FOLLICULAR LYMPHOMA</subject><subject>IN-SITU HYBRIDIZATION</subject><subject>MYELODYSPLASTIC SYNDROME</subject><subject>NEUROBLASTOMA</subject><subject>NON-HODGKINS-LYMPHOMAS</subject><subject>TUMOR-SUPPRESSOR GENE</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>ADGLB</sourceid><recordid>eNqdjcFqwzAQREVoIGnSf9gfCFhSozbntKWXQgg59CbW9treIq-MpRry902gh5xzmpk3DDNTS72zZuNMYR9u_EI9pvRTFFv76txSfR-pYaGeJENsQA_WAYZMI2aOkkBiBpYphomlhcPx7Uu7C4D-TCFyDSg1hHM_dNfQY-BWUCqmtFbzBkOip39dKfPxftp_btru8uUDlyNVmH1E9jhWHU_kf9trVZI32rw8W23vGv0BOwFPIg</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Duhoux, François P</creator><creator>Ameye, Geneviève</creator><creator>Lambot, Virginie</creator><creator>Herens, Christian</creator><creator>Lambert, Frédéric</creator><creator>Raynaud, Sophie</creator><creator>Wlodarska, Iwona</creator><creator>Michaux, Lucienne</creator><creator>Roche-Lestienne, Catherine</creator><creator>Labis, Elise</creator><creator>Taviaux, Sylvie</creator><creator>Chapiro, Elise</creator><creator>Nguyen-Khac, Florence</creator><creator>Struski, Stéphanie</creator><creator>Dobbelstein, Sophie</creator><creator>Dastugue, Nicole</creator><creator>Lippert, Eric</creator><creator>Speleman, Franki</creator><creator>Van Roy, Nadine</creator><creator>De Weer, An</creator><creator>Rack, Katrina</creator><creator>Talmant, Pascaline</creator><creator>Richebourg, Steven</creator><creator>Mugneret, Francine</creator><creator>Tigaud, Isabelle</creator><creator>Mozziconacci, Marie-Joëlle</creator><creator>Laibe, Sophy</creator><creator>Nadal, Nathalie</creator><creator>Terré, Christine</creator><creator>Libouton, Jeanne-Marie</creator><creator>Decottignies, Anabelle</creator><creator>Vikkula, Miikka</creator><creator>Poirel, Hélène A</creator><scope>ADGLB</scope></search><sort><creationdate>2011</creationdate><title>Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies</title><author>Duhoux, François P ; Ameye, Geneviève ; Lambot, Virginie ; Herens, Christian ; Lambert, Frédéric ; Raynaud, Sophie ; Wlodarska, Iwona ; Michaux, Lucienne ; Roche-Lestienne, Catherine ; Labis, Elise ; Taviaux, Sylvie ; Chapiro, Elise ; Nguyen-Khac, Florence ; Struski, Stéphanie ; Dobbelstein, Sophie ; Dastugue, Nicole ; Lippert, Eric ; Speleman, Franki ; Van Roy, Nadine ; De Weer, An ; Rack, Katrina ; Talmant, Pascaline ; Richebourg, Steven ; Mugneret, Francine ; Tigaud, Isabelle ; Mozziconacci, Marie-Joëlle ; Laibe, Sophy ; Nadal, Nathalie ; Terré, Christine ; Libouton, Jeanne-Marie ; Decottignies, Anabelle ; Vikkula, Miikka ; Poirel, Hélène A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-ghent_librecat_oai_archive_ugent_be_21274313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Biology and Life Sciences</topic><topic>CHROMOSOMAL TRANSLOCATIONS</topic><topic>CHRONIC LYMPHOCYTIC-LEUKEMIA</topic><topic>COPY NUMBER</topic><topic>CYTOGENETIC ANALYSIS</topic><topic>FOLLICULAR LYMPHOMA</topic><topic>IN-SITU HYBRIDIZATION</topic><topic>MYELODYSPLASTIC SYNDROME</topic><topic>NEUROBLASTOMA</topic><topic>NON-HODGKINS-LYMPHOMAS</topic><topic>TUMOR-SUPPRESSOR GENE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duhoux, François P</creatorcontrib><creatorcontrib>Ameye, Geneviève</creatorcontrib><creatorcontrib>Lambot, Virginie</creatorcontrib><creatorcontrib>Herens, Christian</creatorcontrib><creatorcontrib>Lambert, Frédéric</creatorcontrib><creatorcontrib>Raynaud, Sophie</creatorcontrib><creatorcontrib>Wlodarska, Iwona</creatorcontrib><creatorcontrib>Michaux, Lucienne</creatorcontrib><creatorcontrib>Roche-Lestienne, Catherine</creatorcontrib><creatorcontrib>Labis, Elise</creatorcontrib><creatorcontrib>Taviaux, Sylvie</creatorcontrib><creatorcontrib>Chapiro, Elise</creatorcontrib><creatorcontrib>Nguyen-Khac, Florence</creatorcontrib><creatorcontrib>Struski, Stéphanie</creatorcontrib><creatorcontrib>Dobbelstein, Sophie</creatorcontrib><creatorcontrib>Dastugue, Nicole</creatorcontrib><creatorcontrib>Lippert, Eric</creatorcontrib><creatorcontrib>Speleman, Franki</creatorcontrib><creatorcontrib>Van Roy, Nadine</creatorcontrib><creatorcontrib>De Weer, An</creatorcontrib><creatorcontrib>Rack, Katrina</creatorcontrib><creatorcontrib>Talmant, Pascaline</creatorcontrib><creatorcontrib>Richebourg, Steven</creatorcontrib><creatorcontrib>Mugneret, Francine</creatorcontrib><creatorcontrib>Tigaud, Isabelle</creatorcontrib><creatorcontrib>Mozziconacci, Marie-Joëlle</creatorcontrib><creatorcontrib>Laibe, Sophy</creatorcontrib><creatorcontrib>Nadal, Nathalie</creatorcontrib><creatorcontrib>Terré, Christine</creatorcontrib><creatorcontrib>Libouton, Jeanne-Marie</creatorcontrib><creatorcontrib>Decottignies, Anabelle</creatorcontrib><creatorcontrib>Vikkula, Miikka</creatorcontrib><creatorcontrib>Poirel, Hélène A</creatorcontrib><collection>Ghent University Academic Bibliography</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duhoux, François P</au><au>Ameye, Geneviève</au><au>Lambot, Virginie</au><au>Herens, Christian</au><au>Lambert, Frédéric</au><au>Raynaud, Sophie</au><au>Wlodarska, Iwona</au><au>Michaux, Lucienne</au><au>Roche-Lestienne, Catherine</au><au>Labis, Elise</au><au>Taviaux, Sylvie</au><au>Chapiro, Elise</au><au>Nguyen-Khac, Florence</au><au>Struski, Stéphanie</au><au>Dobbelstein, Sophie</au><au>Dastugue, Nicole</au><au>Lippert, Eric</au><au>Speleman, Franki</au><au>Van Roy, Nadine</au><au>De Weer, An</au><au>Rack, Katrina</au><au>Talmant, Pascaline</au><au>Richebourg, Steven</au><au>Mugneret, Francine</au><au>Tigaud, Isabelle</au><au>Mozziconacci, Marie-Joëlle</au><au>Laibe, Sophy</au><au>Nadal, Nathalie</au><au>Terré, Christine</au><au>Libouton, Jeanne-Marie</au><au>Decottignies, Anabelle</au><au>Vikkula, Miikka</au><au>Poirel, Hélène A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies</atitle><date>2011</date><risdate>2011</risdate><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Fluorescence in situ hybridization was performed to characterize 81 cases of myeloid and lymphoid malignancies with cytogenetic 1p36 alterations not affecting the PRDM16 locus. In total, three subgroups were identified: balanced translocations (N = 27) and telomeric rearrangements (N = 15), both mainly observed in myeloid disorders; and unbalanced non-telomeric rearrangements (N = 39), mainly observed in lymphoid proliferations and frequently associated with a highly complex karyotype. The 1p36 rearrangement was isolated in 12 cases, mainly myeloid disorders. The breakpoints on 1p36 were more widely distributed than previously reported, but with identifiable rare breakpoint cluster regions, such as the TP73 locus. We also found novel partner loci on 1p36 for the known multi-partner genes HMGA2 and RUNX1. We precised the common terminal 1p36 deletion, which has been suggested to have an adverse prognosis, in B-cell lymphomas [follicular lymphomas and diffuse large B-cell lymphomas with t(14;18)(q32;q21) as well as follicular lymphomas without t(14;18)]. Intrachromosomal telomeric repetitive sequences were detected in at least half the cases of telomeric rearrangements. It is unclear how the latter rearrangements occurred and whether they represent oncogenic events or result from chromosomal instability during oncogenesis.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | Biology and Life Sciences CHROMOSOMAL TRANSLOCATIONS CHRONIC LYMPHOCYTIC-LEUKEMIA COPY NUMBER CYTOGENETIC ANALYSIS FOLLICULAR LYMPHOMA IN-SITU HYBRIDIZATION MYELODYSPLASTIC SYNDROME NEUROBLASTOMA NON-HODGKINS-LYMPHOMAS TUMOR-SUPPRESSOR GENE |
| title | Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies |
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