Preanalytical variables influencing the interpretation and reporting of biological tests on blood samples of living and deceased donors for human body materials
With the present paper, the Working Group on Cells, Tissues and Organs and other experts of the Superior Health Council of Belgium aimed to provide stakeholders in material of human origin with advice on critical aspects of serological and nucleic acid test (NAT) testing, to improve virological safe...
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| creator | Padalko, Elizaveta Colenbie, Luc Delforge, Alain Ectors, Nadine Guns, Johan Imbert, Romain Jansens, Hilde Pirnay, Jean-Paul Rodenbach, Marie-Pierre Van Riet, Ivan Vansteenbrugge, Anne Verbeken, Gilbert Baltes, Muriel Beele, Hilde |
| description | With the present paper, the Working Group on Cells, Tissues and Organs and other experts of the Superior Health Council of Belgium aimed to provide stakeholders in material of human origin with advice on critical aspects of serological and nucleic acid test (NAT) testing, to improve virological safety of cell- and tissue and organ donation. The current paper focusses on a number of preanalytical variables which can be critical for any medical biology examination: (1) sampling related variables (type of samples, collection of the samples, volume of the sample, choice of specific tubes, identification of tubes), (2) variables related to transport, storage and processing of blood samples (transport, centrifugation and haemolysis, storage before and after centrifugation, use of serum versus plasma), (3) variables related to dilution (haemodilution, pooling of samples), and (4) test dependent variables (available tests and validation). Depending on the type of donor (deceased donor (heart-beating or non-heart beating) versus living donor (allogeneic, related, autologous), and the type of donated human material (cells, tissue or organs) additional factors can play a role: pre- and post-mortem sampling, conditions of sampling (e.g. morgue), haemodilution, possibility of retesting. |
| format | Article |
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The current paper focusses on a number of preanalytical variables which can be critical for any medical biology examination: (1) sampling related variables (type of samples, collection of the samples, volume of the sample, choice of specific tubes, identification of tubes), (2) variables related to transport, storage and processing of blood samples (transport, centrifugation and haemolysis, storage before and after centrifugation, use of serum versus plasma), (3) variables related to dilution (haemodilution, pooling of samples), and (4) test dependent variables (available tests and validation). Depending on the type of donor (deceased donor (heart-beating or non-heart beating) versus living donor (allogeneic, related, autologous), and the type of donated human material (cells, tissue or organs) additional factors can play a role: pre- and post-mortem sampling, conditions of sampling (e.g. morgue), haemodilution, possibility of retesting.</description><identifier>ISSN: 1573-6814</identifier><identifier>ISSN: 1389-9333</identifier><language>eng</language><subject>Biological test ; Deceased ; Donor of human body material ; HBV ; HCV ; HEPATITIS-C VIRUS ; HIV ; Living ; Medicine and Health Sciences ; NUCLEIC-ACIDS ; PLASMA SAMPLES ; Post-mortem ; POSTMORTEM BLOOD ; Preanalytical variables ; STABILITY ; STORAGE ; VALIDATION</subject><creationdate>2024</creationdate><rights>Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,315,777,781,4010,27841</link.rule.ids></links><search><creatorcontrib>Padalko, Elizaveta</creatorcontrib><creatorcontrib>Colenbie, Luc</creatorcontrib><creatorcontrib>Delforge, Alain</creatorcontrib><creatorcontrib>Ectors, Nadine</creatorcontrib><creatorcontrib>Guns, Johan</creatorcontrib><creatorcontrib>Imbert, Romain</creatorcontrib><creatorcontrib>Jansens, Hilde</creatorcontrib><creatorcontrib>Pirnay, Jean-Paul</creatorcontrib><creatorcontrib>Rodenbach, Marie-Pierre</creatorcontrib><creatorcontrib>Van Riet, Ivan</creatorcontrib><creatorcontrib>Vansteenbrugge, Anne</creatorcontrib><creatorcontrib>Verbeken, Gilbert</creatorcontrib><creatorcontrib>Baltes, Muriel</creatorcontrib><creatorcontrib>Beele, Hilde</creatorcontrib><title>Preanalytical variables influencing the interpretation and reporting of biological tests on blood samples of living and deceased donors for human body materials</title><description>With the present paper, the Working Group on Cells, Tissues and Organs and other experts of the Superior Health Council of Belgium aimed to provide stakeholders in material of human origin with advice on critical aspects of serological and nucleic acid test (NAT) testing, to improve virological safety of cell- and tissue and organ donation. The current paper focusses on a number of preanalytical variables which can be critical for any medical biology examination: (1) sampling related variables (type of samples, collection of the samples, volume of the sample, choice of specific tubes, identification of tubes), (2) variables related to transport, storage and processing of blood samples (transport, centrifugation and haemolysis, storage before and after centrifugation, use of serum versus plasma), (3) variables related to dilution (haemodilution, pooling of samples), and (4) test dependent variables (available tests and validation). Depending on the type of donor (deceased donor (heart-beating or non-heart beating) versus living donor (allogeneic, related, autologous), and the type of donated human material (cells, tissue or organs) additional factors can play a role: pre- and post-mortem sampling, conditions of sampling (e.g. morgue), haemodilution, possibility of retesting.</description><subject>Biological test</subject><subject>Deceased</subject><subject>Donor of human body material</subject><subject>HBV</subject><subject>HCV</subject><subject>HEPATITIS-C VIRUS</subject><subject>HIV</subject><subject>Living</subject><subject>Medicine and Health Sciences</subject><subject>NUCLEIC-ACIDS</subject><subject>PLASMA SAMPLES</subject><subject>Post-mortem</subject><subject>POSTMORTEM BLOOD</subject><subject>Preanalytical variables</subject><subject>STABILITY</subject><subject>STORAGE</subject><subject>VALIDATION</subject><issn>1573-6814</issn><issn>1389-9333</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ADGLB</sourceid><recordid>eNqtjVtOw0AMRfMBEuWxB2-gUh6Ulu-qEIFUtQJB25-RkziJ0WQczUwidTcslQliCXxdWz73-CKaJYtlNn9YJfdX0bVzX3Gcxss0m0XfO0toUJ89l6hhRMtYaHLAptYDmZJNA76lsHuyvSWPnsUAmgos9WL9BEgNBYuW5lfiyXkHASq0SAUOu34yBkjzOOFTuaKS0FEYxIh1UIuFdugwtKQ6Q4fhHaN2t9FlHYLu_vIm2jxt3tf5vGnJeKW5sFSiV4Ks0JYtj6SGZjoVpOIkP36etunqsD897j72-Vv8_JJsF-vX7L88P0BBdf8</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Padalko, Elizaveta</creator><creator>Colenbie, Luc</creator><creator>Delforge, Alain</creator><creator>Ectors, Nadine</creator><creator>Guns, Johan</creator><creator>Imbert, Romain</creator><creator>Jansens, Hilde</creator><creator>Pirnay, Jean-Paul</creator><creator>Rodenbach, Marie-Pierre</creator><creator>Van Riet, Ivan</creator><creator>Vansteenbrugge, Anne</creator><creator>Verbeken, Gilbert</creator><creator>Baltes, Muriel</creator><creator>Beele, Hilde</creator><scope>ADGLB</scope></search><sort><creationdate>2024</creationdate><title>Preanalytical variables influencing the interpretation and reporting of biological tests on blood samples of living and deceased donors for human body materials</title><author>Padalko, Elizaveta ; Colenbie, Luc ; Delforge, Alain ; Ectors, Nadine ; Guns, Johan ; Imbert, Romain ; Jansens, Hilde ; Pirnay, Jean-Paul ; Rodenbach, Marie-Pierre ; Van Riet, Ivan ; Vansteenbrugge, Anne ; Verbeken, Gilbert ; Baltes, Muriel ; Beele, Hilde</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-ghent_librecat_oai_archive_ugent_be_01HYWZN28XQZ9PVQHS0GJ1N5CK3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biological test</topic><topic>Deceased</topic><topic>Donor of human body material</topic><topic>HBV</topic><topic>HCV</topic><topic>HEPATITIS-C VIRUS</topic><topic>HIV</topic><topic>Living</topic><topic>Medicine and Health Sciences</topic><topic>NUCLEIC-ACIDS</topic><topic>PLASMA SAMPLES</topic><topic>Post-mortem</topic><topic>POSTMORTEM BLOOD</topic><topic>Preanalytical variables</topic><topic>STABILITY</topic><topic>STORAGE</topic><topic>VALIDATION</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Padalko, Elizaveta</creatorcontrib><creatorcontrib>Colenbie, Luc</creatorcontrib><creatorcontrib>Delforge, Alain</creatorcontrib><creatorcontrib>Ectors, Nadine</creatorcontrib><creatorcontrib>Guns, Johan</creatorcontrib><creatorcontrib>Imbert, Romain</creatorcontrib><creatorcontrib>Jansens, Hilde</creatorcontrib><creatorcontrib>Pirnay, Jean-Paul</creatorcontrib><creatorcontrib>Rodenbach, Marie-Pierre</creatorcontrib><creatorcontrib>Van Riet, Ivan</creatorcontrib><creatorcontrib>Vansteenbrugge, Anne</creatorcontrib><creatorcontrib>Verbeken, Gilbert</creatorcontrib><creatorcontrib>Baltes, Muriel</creatorcontrib><creatorcontrib>Beele, Hilde</creatorcontrib><collection>Ghent University Academic Bibliography</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Padalko, Elizaveta</au><au>Colenbie, Luc</au><au>Delforge, Alain</au><au>Ectors, Nadine</au><au>Guns, Johan</au><au>Imbert, Romain</au><au>Jansens, Hilde</au><au>Pirnay, Jean-Paul</au><au>Rodenbach, Marie-Pierre</au><au>Van Riet, Ivan</au><au>Vansteenbrugge, Anne</au><au>Verbeken, Gilbert</au><au>Baltes, Muriel</au><au>Beele, Hilde</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preanalytical variables influencing the interpretation and reporting of biological tests on blood samples of living and deceased donors for human body materials</atitle><date>2024</date><risdate>2024</risdate><issn>1573-6814</issn><issn>1389-9333</issn><abstract>With the present paper, the Working Group on Cells, Tissues and Organs and other experts of the Superior Health Council of Belgium aimed to provide stakeholders in material of human origin with advice on critical aspects of serological and nucleic acid test (NAT) testing, to improve virological safety of cell- and tissue and organ donation. The current paper focusses on a number of preanalytical variables which can be critical for any medical biology examination: (1) sampling related variables (type of samples, collection of the samples, volume of the sample, choice of specific tubes, identification of tubes), (2) variables related to transport, storage and processing of blood samples (transport, centrifugation and haemolysis, storage before and after centrifugation, use of serum versus plasma), (3) variables related to dilution (haemodilution, pooling of samples), and (4) test dependent variables (available tests and validation). Depending on the type of donor (deceased donor (heart-beating or non-heart beating) versus living donor (allogeneic, related, autologous), and the type of donated human material (cells, tissue or organs) additional factors can play a role: pre- and post-mortem sampling, conditions of sampling (e.g. morgue), haemodilution, possibility of retesting.</abstract><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1573-6814 |
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| issn | 1573-6814 1389-9333 |
| language | eng |
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| source | Ghent University Academic Bibliography; Springer Nature - Complete Springer Journals |
| subjects | Biological test Deceased Donor of human body material HBV HCV HEPATITIS-C VIRUS HIV Living Medicine and Health Sciences NUCLEIC-ACIDS PLASMA SAMPLES Post-mortem POSTMORTEM BLOOD Preanalytical variables STABILITY STORAGE VALIDATION |
| title | Preanalytical variables influencing the interpretation and reporting of biological tests on blood samples of living and deceased donors for human body materials |
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