Does the impact of COVID‐19 on patients with systemic sclerosis change over time?
Objective. The outcome of patients with COVID-19 improved over the pandemic, including patients with systemic rheumatic diseases. However, data on patients with systemic sclerosis (SSc) are lacking. This study aimed to assess the outcome of patients with both SSc and COVID-19 over several waves.Meth...
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| creator | Deibel, Elisabeth Carreira, Patricia E Vonk, Madelon del Papa, Nicoletta Bečvář, Radim Guillén‐Del‐Castillo, Alfredo Campochiaro, Corrado Poormoghim, Hadi Liem, Sophie Lazzaroni, Maria‐Grazia Giollo, Alessandro Mekinian, Arsène de Vries‐Bouwstra, Jeska De Santis, Maria Balbir‐Gurman, Alexandra Mihai, Carina De Luca, Giacomo Moiseev, Sergey Zanatta, Elisabetta Foti, Rosario Rednic, Simona Denton, Christopher Cutolo, Maurizio Belloli, Laura Airo, Paolo Garzanova, Liudmila Moroncini, Gianluca İnanç, Murat Panopoulos, Stylianos Tandaipan, Jose‐Luis Chatelus, Emmanuel Rosato, Edoardo Kuwana, Masataka Yavuz, Sule Alegre‐Sancho, Juan J Smith, Vanessa Szűcs, Gabriella Henes, Joerg Rodríguez‐Pintó, Ignasi Atzeni, Fabiola Spierings, Julia Truchetet, Marie‐Elise Milchert, Marcin Brito de Araujo, Daniel Riemekasten, Gabriela Bernardino, Vera Martin, Thierry del Galdo, Francesco Vacca, Alessandra Mendoza, Fabian Midtvedt, Øyvind Murdaca, Giuseppe Santiago, Tânia Codullo, Veronica Cacciapaglia, Fabio Walker, Ulrich Brunborg, Cathrine Tirelli, Francesca Allanore, Yannick Furst, Daniel E Matucci, Marco Gabrielli, Armando Distler, Oliver Hoffmann‐Vold, Anna‐Maria |
| description | Objective. The outcome of patients with COVID-19 improved over the pandemic, including patients with systemic rheumatic diseases. However, data on patients with systemic sclerosis (SSc) are lacking. This study aimed to assess the outcome of patients with both SSc and COVID-19 over several waves.Methods. Patients with both SSc and COVID-19 who were registered in the European Scleroderma Trials and Research group (EUSTAR) were collected between April 2020 and April 2021. Patients were assigned to waves 1, 2, or 3 depending on the date of their COVID-19 diagnosis. Primary endpoints were death, intensive care unit stay, or ventilatory support (severe outcome). Subgroup analyses of patients who were hospitalized or died were conducted. General and SSc-specific characteristics and treatment were compared over the waves. Descriptive statistics and multivariate logistic regression were applied.Results. A total of 333 patients were included; 57 patients (17%) had a severe outcome, and 30 patients (9%) died. Compared to wave 1, significantly fewer patients with SSc suffered from severe COVID-19 in waves 2 and 3 (28.2% vs 9.8% and 12.7%; P < 0.001), fewer patients required hospitalization (46.7% vs 19.6% and 25.5%; P < 0.001) or ventilatory support (24.0% vs 8.7% and 10.9%; P = 0.001), and fewer patients died (15.7% vs 5.0% and 7.5%; P = 0.011). Patients were significantly younger, more often men, had less frequent arterial hypertension, and less SSc cardiac involvement over waves 1 to 3. Patients received significantly less medium to high doses of corticosteroids as they did SSc treatment.Conclusion. The outcome of patients with both SSc and COVID-19 improved significantly over time because of intrinsic and extrinsic factors. |
| format | Article |
| fullrecord | <record><control><sourceid>ghent</sourceid><recordid>TN_cdi_ghent_librecat_oai_archive_ugent_be_01HJ8YK3MCB4GSGNZ6BNT9KA1X</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>oai_archive_ugent_be_01HJ8YK3MCB4GSGNZ6BNT9KA1X</sourcerecordid><originalsourceid>FETCH-ghent_librecat_oai_archive_ugent_be_01HJ8YK3MCB4GSGNZ6BNT9KA1X3</originalsourceid><addsrcrecordid>eNqtjEuKwkAUAHuhoKh3eBcQbGMkWQ0a_6KzUERn07TNM_2GJC15reLOI8wZPckozBGmNrUoqIqod2Uo271-GNVEi_m78yLoRlEQ18Vm5JDBWwTKz9p4cCdIPnfz0fPxI2NwBZy1Jyw8w428Bb6zx5wMsMmwdEwMxuoiRXBXLMFTjh9NUT3pjLH154YYT8bbZNZO7WukMjqWaLRXTpPSpbF0RXVJ3-mIqiNni-iwDFbJsDfdTNdf_eF6Gy8Hch_81-cXBHlX-w</addsrcrecordid><sourcetype>Institutional Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Does the impact of COVID‐19 on patients with systemic sclerosis change over time?</title><source>Wiley Online Library Journals Frontfile Complete</source><source>Ghent University Academic Bibliography</source><creator>Deibel, Elisabeth ; Carreira, Patricia E ; Vonk, Madelon ; del Papa, Nicoletta ; Bečvář, Radim ; Guillén‐Del‐Castillo, Alfredo ; Campochiaro, Corrado ; Poormoghim, Hadi ; Liem, Sophie ; Lazzaroni, Maria‐Grazia ; Giollo, Alessandro ; Mekinian, Arsène ; de Vries‐Bouwstra, Jeska ; De Santis, Maria ; Balbir‐Gurman, Alexandra ; Mihai, Carina ; De Luca, Giacomo ; Moiseev, Sergey ; Zanatta, Elisabetta ; Foti, Rosario ; Rednic, Simona ; Denton, Christopher ; Cutolo, Maurizio ; Belloli, Laura ; Airo, Paolo ; Garzanova, Liudmila ; Moroncini, Gianluca ; İnanç, Murat ; Panopoulos, Stylianos ; Tandaipan, Jose‐Luis ; Chatelus, Emmanuel ; Rosato, Edoardo ; Kuwana, Masataka ; Yavuz, Sule ; Alegre‐Sancho, Juan J ; Smith, Vanessa ; Szűcs, Gabriella ; Henes, Joerg ; Rodríguez‐Pintó, Ignasi ; Atzeni, Fabiola ; Spierings, Julia ; Truchetet, Marie‐Elise ; Milchert, Marcin ; Brito de Araujo, Daniel ; Riemekasten, Gabriela ; Bernardino, Vera ; Martin, Thierry ; del Galdo, Francesco ; Vacca, Alessandra ; Mendoza, Fabian ; Midtvedt, Øyvind ; Murdaca, Giuseppe ; Santiago, Tânia ; Codullo, Veronica ; Cacciapaglia, Fabio ; Walker, Ulrich ; Brunborg, Cathrine ; Tirelli, Francesca ; Allanore, Yannick ; Furst, Daniel E ; Matucci, Marco ; Gabrielli, Armando ; Distler, Oliver ; Hoffmann‐Vold, Anna‐Maria</creator><creatorcontrib>Deibel, Elisabeth ; Carreira, Patricia E ; Vonk, Madelon ; del Papa, Nicoletta ; Bečvář, Radim ; Guillén‐Del‐Castillo, Alfredo ; Campochiaro, Corrado ; Poormoghim, Hadi ; Liem, Sophie ; Lazzaroni, Maria‐Grazia ; Giollo, Alessandro ; Mekinian, Arsène ; de Vries‐Bouwstra, Jeska ; De Santis, Maria ; Balbir‐Gurman, Alexandra ; Mihai, Carina ; De Luca, Giacomo ; Moiseev, Sergey ; Zanatta, Elisabetta ; Foti, Rosario ; Rednic, Simona ; Denton, Christopher ; Cutolo, Maurizio ; Belloli, Laura ; Airo, Paolo ; Garzanova, Liudmila ; Moroncini, Gianluca ; İnanç, Murat ; Panopoulos, Stylianos ; Tandaipan, Jose‐Luis ; Chatelus, Emmanuel ; Rosato, Edoardo ; Kuwana, Masataka ; Yavuz, Sule ; Alegre‐Sancho, Juan J ; Smith, Vanessa ; Szűcs, Gabriella ; Henes, Joerg ; Rodríguez‐Pintó, Ignasi ; Atzeni, Fabiola ; Spierings, Julia ; Truchetet, Marie‐Elise ; Milchert, Marcin ; Brito de Araujo, Daniel ; Riemekasten, Gabriela ; Bernardino, Vera ; Martin, Thierry ; del Galdo, Francesco ; Vacca, Alessandra ; Mendoza, Fabian ; Midtvedt, Øyvind ; Murdaca, Giuseppe ; Santiago, Tânia ; Codullo, Veronica ; Cacciapaglia, Fabio ; Walker, Ulrich ; Brunborg, Cathrine ; Tirelli, Francesca ; Allanore, Yannick ; Furst, Daniel E ; Matucci, Marco ; Gabrielli, Armando ; Distler, Oliver ; Hoffmann‐Vold, Anna‐Maria</creatorcontrib><description>Objective. The outcome of patients with COVID-19 improved over the pandemic, including patients with systemic rheumatic diseases. However, data on patients with systemic sclerosis (SSc) are lacking. This study aimed to assess the outcome of patients with both SSc and COVID-19 over several waves.Methods. Patients with both SSc and COVID-19 who were registered in the European Scleroderma Trials and Research group (EUSTAR) were collected between April 2020 and April 2021. Patients were assigned to waves 1, 2, or 3 depending on the date of their COVID-19 diagnosis. Primary endpoints were death, intensive care unit stay, or ventilatory support (severe outcome). Subgroup analyses of patients who were hospitalized or died were conducted. General and SSc-specific characteristics and treatment were compared over the waves. Descriptive statistics and multivariate logistic regression were applied.Results. A total of 333 patients were included; 57 patients (17%) had a severe outcome, and 30 patients (9%) died. Compared to wave 1, significantly fewer patients with SSc suffered from severe COVID-19 in waves 2 and 3 (28.2% vs 9.8% and 12.7%; P < 0.001), fewer patients required hospitalization (46.7% vs 19.6% and 25.5%; P < 0.001) or ventilatory support (24.0% vs 8.7% and 10.9%; P = 0.001), and fewer patients died (15.7% vs 5.0% and 7.5%; P = 0.011). Patients were significantly younger, more often men, had less frequent arterial hypertension, and less SSc cardiac involvement over waves 1 to 3. Patients received significantly less medium to high doses of corticosteroids as they did SSc treatment.Conclusion. The outcome of patients with both SSc and COVID-19 improved significantly over time because of intrinsic and extrinsic factors.</description><identifier>ISSN: 2151-4658</identifier><identifier>ISSN: 2151-464X</identifier><language>eng</language><publisher>Wiley</publisher><subject>Medicine and Health Sciences ; Rheumatology</subject><creationdate>2024</creationdate><rights>Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Public License (CC BY-NC-ND 4.0) info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,315,777,781,4010,27841</link.rule.ids></links><search><creatorcontrib>Deibel, Elisabeth</creatorcontrib><creatorcontrib>Carreira, Patricia E</creatorcontrib><creatorcontrib>Vonk, Madelon</creatorcontrib><creatorcontrib>del Papa, Nicoletta</creatorcontrib><creatorcontrib>Bečvář, Radim</creatorcontrib><creatorcontrib>Guillén‐Del‐Castillo, Alfredo</creatorcontrib><creatorcontrib>Campochiaro, Corrado</creatorcontrib><creatorcontrib>Poormoghim, Hadi</creatorcontrib><creatorcontrib>Liem, Sophie</creatorcontrib><creatorcontrib>Lazzaroni, Maria‐Grazia</creatorcontrib><creatorcontrib>Giollo, Alessandro</creatorcontrib><creatorcontrib>Mekinian, Arsène</creatorcontrib><creatorcontrib>de Vries‐Bouwstra, Jeska</creatorcontrib><creatorcontrib>De Santis, Maria</creatorcontrib><creatorcontrib>Balbir‐Gurman, Alexandra</creatorcontrib><creatorcontrib>Mihai, Carina</creatorcontrib><creatorcontrib>De Luca, Giacomo</creatorcontrib><creatorcontrib>Moiseev, Sergey</creatorcontrib><creatorcontrib>Zanatta, Elisabetta</creatorcontrib><creatorcontrib>Foti, Rosario</creatorcontrib><creatorcontrib>Rednic, Simona</creatorcontrib><creatorcontrib>Denton, Christopher</creatorcontrib><creatorcontrib>Cutolo, Maurizio</creatorcontrib><creatorcontrib>Belloli, Laura</creatorcontrib><creatorcontrib>Airo, Paolo</creatorcontrib><creatorcontrib>Garzanova, Liudmila</creatorcontrib><creatorcontrib>Moroncini, Gianluca</creatorcontrib><creatorcontrib>İnanç, Murat</creatorcontrib><creatorcontrib>Panopoulos, Stylianos</creatorcontrib><creatorcontrib>Tandaipan, Jose‐Luis</creatorcontrib><creatorcontrib>Chatelus, Emmanuel</creatorcontrib><creatorcontrib>Rosato, Edoardo</creatorcontrib><creatorcontrib>Kuwana, Masataka</creatorcontrib><creatorcontrib>Yavuz, Sule</creatorcontrib><creatorcontrib>Alegre‐Sancho, Juan J</creatorcontrib><creatorcontrib>Smith, Vanessa</creatorcontrib><creatorcontrib>Szűcs, Gabriella</creatorcontrib><creatorcontrib>Henes, Joerg</creatorcontrib><creatorcontrib>Rodríguez‐Pintó, Ignasi</creatorcontrib><creatorcontrib>Atzeni, Fabiola</creatorcontrib><creatorcontrib>Spierings, Julia</creatorcontrib><creatorcontrib>Truchetet, Marie‐Elise</creatorcontrib><creatorcontrib>Milchert, Marcin</creatorcontrib><creatorcontrib>Brito de Araujo, Daniel</creatorcontrib><creatorcontrib>Riemekasten, Gabriela</creatorcontrib><creatorcontrib>Bernardino, Vera</creatorcontrib><creatorcontrib>Martin, Thierry</creatorcontrib><creatorcontrib>del Galdo, Francesco</creatorcontrib><creatorcontrib>Vacca, Alessandra</creatorcontrib><creatorcontrib>Mendoza, Fabian</creatorcontrib><creatorcontrib>Midtvedt, Øyvind</creatorcontrib><creatorcontrib>Murdaca, Giuseppe</creatorcontrib><creatorcontrib>Santiago, Tânia</creatorcontrib><creatorcontrib>Codullo, Veronica</creatorcontrib><creatorcontrib>Cacciapaglia, Fabio</creatorcontrib><creatorcontrib>Walker, Ulrich</creatorcontrib><creatorcontrib>Brunborg, Cathrine</creatorcontrib><creatorcontrib>Tirelli, Francesca</creatorcontrib><creatorcontrib>Allanore, Yannick</creatorcontrib><creatorcontrib>Furst, Daniel E</creatorcontrib><creatorcontrib>Matucci, Marco</creatorcontrib><creatorcontrib>Gabrielli, Armando</creatorcontrib><creatorcontrib>Distler, Oliver</creatorcontrib><creatorcontrib>Hoffmann‐Vold, Anna‐Maria</creatorcontrib><title>Does the impact of COVID‐19 on patients with systemic sclerosis change over time?</title><description>Objective. The outcome of patients with COVID-19 improved over the pandemic, including patients with systemic rheumatic diseases. However, data on patients with systemic sclerosis (SSc) are lacking. This study aimed to assess the outcome of patients with both SSc and COVID-19 over several waves.Methods. Patients with both SSc and COVID-19 who were registered in the European Scleroderma Trials and Research group (EUSTAR) were collected between April 2020 and April 2021. Patients were assigned to waves 1, 2, or 3 depending on the date of their COVID-19 diagnosis. Primary endpoints were death, intensive care unit stay, or ventilatory support (severe outcome). Subgroup analyses of patients who were hospitalized or died were conducted. General and SSc-specific characteristics and treatment were compared over the waves. Descriptive statistics and multivariate logistic regression were applied.Results. A total of 333 patients were included; 57 patients (17%) had a severe outcome, and 30 patients (9%) died. Compared to wave 1, significantly fewer patients with SSc suffered from severe COVID-19 in waves 2 and 3 (28.2% vs 9.8% and 12.7%; P < 0.001), fewer patients required hospitalization (46.7% vs 19.6% and 25.5%; P < 0.001) or ventilatory support (24.0% vs 8.7% and 10.9%; P = 0.001), and fewer patients died (15.7% vs 5.0% and 7.5%; P = 0.011). Patients were significantly younger, more often men, had less frequent arterial hypertension, and less SSc cardiac involvement over waves 1 to 3. Patients received significantly less medium to high doses of corticosteroids as they did SSc treatment.Conclusion. The outcome of patients with both SSc and COVID-19 improved significantly over time because of intrinsic and extrinsic factors.</description><subject>Medicine and Health Sciences</subject><subject>Rheumatology</subject><issn>2151-4658</issn><issn>2151-464X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ADGLB</sourceid><recordid>eNqtjEuKwkAUAHuhoKh3eBcQbGMkWQ0a_6KzUERn07TNM_2GJC15reLOI8wZPckozBGmNrUoqIqod2Uo271-GNVEi_m78yLoRlEQ18Vm5JDBWwTKz9p4cCdIPnfz0fPxI2NwBZy1Jyw8w428Bb6zx5wMsMmwdEwMxuoiRXBXLMFTjh9NUT3pjLH154YYT8bbZNZO7WukMjqWaLRXTpPSpbF0RXVJ3-mIqiNni-iwDFbJsDfdTNdf_eF6Gy8Hch_81-cXBHlX-w</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Deibel, Elisabeth</creator><creator>Carreira, Patricia E</creator><creator>Vonk, Madelon</creator><creator>del Papa, Nicoletta</creator><creator>Bečvář, Radim</creator><creator>Guillén‐Del‐Castillo, Alfredo</creator><creator>Campochiaro, Corrado</creator><creator>Poormoghim, Hadi</creator><creator>Liem, Sophie</creator><creator>Lazzaroni, Maria‐Grazia</creator><creator>Giollo, Alessandro</creator><creator>Mekinian, Arsène</creator><creator>de Vries‐Bouwstra, Jeska</creator><creator>De Santis, Maria</creator><creator>Balbir‐Gurman, Alexandra</creator><creator>Mihai, Carina</creator><creator>De Luca, Giacomo</creator><creator>Moiseev, Sergey</creator><creator>Zanatta, Elisabetta</creator><creator>Foti, Rosario</creator><creator>Rednic, Simona</creator><creator>Denton, Christopher</creator><creator>Cutolo, Maurizio</creator><creator>Belloli, Laura</creator><creator>Airo, Paolo</creator><creator>Garzanova, Liudmila</creator><creator>Moroncini, Gianluca</creator><creator>İnanç, Murat</creator><creator>Panopoulos, Stylianos</creator><creator>Tandaipan, Jose‐Luis</creator><creator>Chatelus, Emmanuel</creator><creator>Rosato, Edoardo</creator><creator>Kuwana, Masataka</creator><creator>Yavuz, Sule</creator><creator>Alegre‐Sancho, Juan J</creator><creator>Smith, Vanessa</creator><creator>Szűcs, Gabriella</creator><creator>Henes, Joerg</creator><creator>Rodríguez‐Pintó, Ignasi</creator><creator>Atzeni, Fabiola</creator><creator>Spierings, Julia</creator><creator>Truchetet, Marie‐Elise</creator><creator>Milchert, Marcin</creator><creator>Brito de Araujo, Daniel</creator><creator>Riemekasten, Gabriela</creator><creator>Bernardino, Vera</creator><creator>Martin, Thierry</creator><creator>del Galdo, Francesco</creator><creator>Vacca, Alessandra</creator><creator>Mendoza, Fabian</creator><creator>Midtvedt, Øyvind</creator><creator>Murdaca, Giuseppe</creator><creator>Santiago, Tânia</creator><creator>Codullo, Veronica</creator><creator>Cacciapaglia, Fabio</creator><creator>Walker, Ulrich</creator><creator>Brunborg, Cathrine</creator><creator>Tirelli, Francesca</creator><creator>Allanore, Yannick</creator><creator>Furst, Daniel E</creator><creator>Matucci, Marco</creator><creator>Gabrielli, Armando</creator><creator>Distler, Oliver</creator><creator>Hoffmann‐Vold, Anna‐Maria</creator><general>Wiley</general><scope>ADGLB</scope></search><sort><creationdate>2024</creationdate><title>Does the impact of COVID‐19 on patients with systemic sclerosis change over time?</title><author>Deibel, Elisabeth ; Carreira, Patricia E ; Vonk, Madelon ; del Papa, Nicoletta ; Bečvář, Radim ; Guillén‐Del‐Castillo, Alfredo ; Campochiaro, Corrado ; Poormoghim, Hadi ; Liem, Sophie ; Lazzaroni, Maria‐Grazia ; Giollo, Alessandro ; Mekinian, Arsène ; de Vries‐Bouwstra, Jeska ; De Santis, Maria ; Balbir‐Gurman, Alexandra ; Mihai, Carina ; De Luca, Giacomo ; Moiseev, Sergey ; Zanatta, Elisabetta ; Foti, Rosario ; Rednic, Simona ; Denton, Christopher ; Cutolo, Maurizio ; Belloli, Laura ; Airo, Paolo ; Garzanova, Liudmila ; Moroncini, Gianluca ; İnanç, Murat ; Panopoulos, Stylianos ; Tandaipan, Jose‐Luis ; Chatelus, Emmanuel ; Rosato, Edoardo ; Kuwana, Masataka ; 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Gabriella</creatorcontrib><creatorcontrib>Henes, Joerg</creatorcontrib><creatorcontrib>Rodríguez‐Pintó, Ignasi</creatorcontrib><creatorcontrib>Atzeni, Fabiola</creatorcontrib><creatorcontrib>Spierings, Julia</creatorcontrib><creatorcontrib>Truchetet, Marie‐Elise</creatorcontrib><creatorcontrib>Milchert, Marcin</creatorcontrib><creatorcontrib>Brito de Araujo, Daniel</creatorcontrib><creatorcontrib>Riemekasten, Gabriela</creatorcontrib><creatorcontrib>Bernardino, Vera</creatorcontrib><creatorcontrib>Martin, Thierry</creatorcontrib><creatorcontrib>del Galdo, Francesco</creatorcontrib><creatorcontrib>Vacca, Alessandra</creatorcontrib><creatorcontrib>Mendoza, Fabian</creatorcontrib><creatorcontrib>Midtvedt, Øyvind</creatorcontrib><creatorcontrib>Murdaca, Giuseppe</creatorcontrib><creatorcontrib>Santiago, Tânia</creatorcontrib><creatorcontrib>Codullo, Veronica</creatorcontrib><creatorcontrib>Cacciapaglia, Fabio</creatorcontrib><creatorcontrib>Walker, Ulrich</creatorcontrib><creatorcontrib>Brunborg, Cathrine</creatorcontrib><creatorcontrib>Tirelli, Francesca</creatorcontrib><creatorcontrib>Allanore, Yannick</creatorcontrib><creatorcontrib>Furst, Daniel E</creatorcontrib><creatorcontrib>Matucci, Marco</creatorcontrib><creatorcontrib>Gabrielli, Armando</creatorcontrib><creatorcontrib>Distler, Oliver</creatorcontrib><creatorcontrib>Hoffmann‐Vold, Anna‐Maria</creatorcontrib><collection>Ghent University Academic Bibliography</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deibel, Elisabeth</au><au>Carreira, Patricia E</au><au>Vonk, Madelon</au><au>del Papa, Nicoletta</au><au>Bečvář, Radim</au><au>Guillén‐Del‐Castillo, Alfredo</au><au>Campochiaro, Corrado</au><au>Poormoghim, Hadi</au><au>Liem, Sophie</au><au>Lazzaroni, Maria‐Grazia</au><au>Giollo, Alessandro</au><au>Mekinian, Arsène</au><au>de Vries‐Bouwstra, Jeska</au><au>De Santis, Maria</au><au>Balbir‐Gurman, Alexandra</au><au>Mihai, Carina</au><au>De Luca, Giacomo</au><au>Moiseev, Sergey</au><au>Zanatta, Elisabetta</au><au>Foti, Rosario</au><au>Rednic, Simona</au><au>Denton, Christopher</au><au>Cutolo, Maurizio</au><au>Belloli, Laura</au><au>Airo, Paolo</au><au>Garzanova, Liudmila</au><au>Moroncini, Gianluca</au><au>İnanç, Murat</au><au>Panopoulos, Stylianos</au><au>Tandaipan, Jose‐Luis</au><au>Chatelus, Emmanuel</au><au>Rosato, Edoardo</au><au>Kuwana, Masataka</au><au>Yavuz, Sule</au><au>Alegre‐Sancho, Juan J</au><au>Smith, Vanessa</au><au>Szűcs, Gabriella</au><au>Henes, Joerg</au><au>Rodríguez‐Pintó, Ignasi</au><au>Atzeni, Fabiola</au><au>Spierings, Julia</au><au>Truchetet, Marie‐Elise</au><au>Milchert, Marcin</au><au>Brito de Araujo, Daniel</au><au>Riemekasten, Gabriela</au><au>Bernardino, Vera</au><au>Martin, Thierry</au><au>del Galdo, Francesco</au><au>Vacca, Alessandra</au><au>Mendoza, Fabian</au><au>Midtvedt, Øyvind</au><au>Murdaca, Giuseppe</au><au>Santiago, Tânia</au><au>Codullo, Veronica</au><au>Cacciapaglia, Fabio</au><au>Walker, Ulrich</au><au>Brunborg, Cathrine</au><au>Tirelli, Francesca</au><au>Allanore, Yannick</au><au>Furst, Daniel E</au><au>Matucci, Marco</au><au>Gabrielli, Armando</au><au>Distler, Oliver</au><au>Hoffmann‐Vold, Anna‐Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does the impact of COVID‐19 on patients with systemic sclerosis change over time?</atitle><date>2024</date><risdate>2024</risdate><issn>2151-4658</issn><issn>2151-464X</issn><abstract>Objective. The outcome of patients with COVID-19 improved over the pandemic, including patients with systemic rheumatic diseases. However, data on patients with systemic sclerosis (SSc) are lacking. This study aimed to assess the outcome of patients with both SSc and COVID-19 over several waves.Methods. Patients with both SSc and COVID-19 who were registered in the European Scleroderma Trials and Research group (EUSTAR) were collected between April 2020 and April 2021. Patients were assigned to waves 1, 2, or 3 depending on the date of their COVID-19 diagnosis. Primary endpoints were death, intensive care unit stay, or ventilatory support (severe outcome). Subgroup analyses of patients who were hospitalized or died were conducted. General and SSc-specific characteristics and treatment were compared over the waves. Descriptive statistics and multivariate logistic regression were applied.Results. A total of 333 patients were included; 57 patients (17%) had a severe outcome, and 30 patients (9%) died. Compared to wave 1, significantly fewer patients with SSc suffered from severe COVID-19 in waves 2 and 3 (28.2% vs 9.8% and 12.7%; P < 0.001), fewer patients required hospitalization (46.7% vs 19.6% and 25.5%; P < 0.001) or ventilatory support (24.0% vs 8.7% and 10.9%; P = 0.001), and fewer patients died (15.7% vs 5.0% and 7.5%; P = 0.011). Patients were significantly younger, more often men, had less frequent arterial hypertension, and less SSc cardiac involvement over waves 1 to 3. Patients received significantly less medium to high doses of corticosteroids as they did SSc treatment.Conclusion. The outcome of patients with both SSc and COVID-19 improved significantly over time because of intrinsic and extrinsic factors.</abstract><pub>Wiley</pub><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2151-4658 |
| ispartof | |
| issn | 2151-4658 2151-464X |
| language | eng |
| recordid | cdi_ghent_librecat_oai_archive_ugent_be_01HJ8YK3MCB4GSGNZ6BNT9KA1X |
| source | Wiley Online Library Journals Frontfile Complete; Ghent University Academic Bibliography |
| subjects | Medicine and Health Sciences Rheumatology |
| title | Does the impact of COVID‐19 on patients with systemic sclerosis change over time? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T03%3A30%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-ghent&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Does%20the%20impact%20of%20COVID%E2%80%9019%20on%20patients%20with%20systemic%20sclerosis%20change%20over%20time?&rft.au=Deibel,%20Elisabeth&rft.date=2024&rft.issn=2151-4658&rft_id=info:doi/&rft_dat=%3Cghent%3Eoai_archive_ugent_be_01HJ8YK3MCB4GSGNZ6BNT9KA1X%3C/ghent%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |