Adeno-associated virus serotype 2 capsid variants for improved liver-directed gene therapy

Background and Aims Current liver-directed gene therapies look for adeno-associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in h...

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Hauptverfasser:	Meumann, N, Cabanes-Creus, M, Ertelt, M, Navarro, RG, Lucifora, J, Yuan, Q, Nien-Huber, K, Abdelrahman, A, Vu, XK, Zhang, L, Franke, AC, Schmithals, C, Piiper, A, Vogt, A, Gonzalez-Carmona, M, Frueh, JT, Ullrich, E, Meuleman, Philip, Talbot, SR, Odenthal, M, Ott, M, Seifried, E, Schoeder, CT, Schwäble, J, Lisowski, L, Büning, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences Medicine and Health Sciences
Online-Zugang:	Volltext
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