Addressing personal protective equipment (PPE) decontamination : methylene blue and light inactivates severe acute respiratory coronavirus virus 2 (SARS-CoV-2) on N95 respirators and medical masks with maintenance of integrity and fit
Objective: The coronavirus disease 2019 (COVID-19) pandemic has resulted in shortages of personal protective equipment (PPE), underscoring the urgent need for simple, efficient, and inexpensive methods to decontaminate masks and respirators exposed to severe acute respiratory coronavirus virus 2 (SA...
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creator | Lendvay, Thomas Sean Chen, James Harcourt, Brian H Scholte, Florine E. M Lin, Ying Ling Kilinc-Balci, F. Selcen Lamb, Molly M Homdayjanakul, Kamonthip Cui, Yi Price, Amy Heyne, Belinda Sahni, Jaya Kabra, Kareem B Lin, Yi-Chan Evans, David Mores, Christopher N Page, Ken Chu, Larry F Haubruge, Eric Thiry, Etienne Ludwig-Begall, Louisa F Wielick, Constance Clark, Tanner Wagner, Thor Timm, Emily Gallagher, Thomas Faris, Peter Macia, Nicolas Mackie, Cyrus J Simmons, Sarah M Reader, Susan Malott, Rebecca Hope, Karen Davies, Jan M Tritsch, Sarah R Dams, Lorene Nauwynck, Hans Willaert, Jean-Francois De Jaeger, Simon Liao, Lei Zhao, Mervin Laperre, Jan Jolois, Olivier Smit, Sarah J Patel, Alpa N Mayo, Mark Parker, Rod Molloy-Simard, Vanessa Lemyre, Jean-Luc Chu, Steven Conly, John M Chu, May C |
description | Objective: The coronavirus disease 2019 (COVID-19) pandemic has resulted in shortages of personal protective equipment (PPE), underscoring the urgent need for simple, efficient, and inexpensive methods to decontaminate masks and respirators exposed to severe acute respiratory coronavirus virus 2 (SARS-CoV-2). We hypothesized that methylene blue (MB) photochemical treatment, which has various clinical applications, could decontaminate PPE contaminated with coronavirus. Design: The 2 arms of the study included (1) PPE inoculation with coronaviruses followed by MB with light (MBL) decontamination treatment and (2) PPE treatment with MBL for 5 cycles of decontamination to determine maintenance of PPE performance. Methods: MBL treatment was used to inactivate coronaviruses on 3 N95 filtering facepiece respirator (FFR) and 2 medical mask models. We inoculated FFR and medical mask materials with 3 coronaviruses, including SARS-CoV-2, and we treated them with 10 mu M MB and exposed them to 50,000 lux of white light or 12,500 lux of red light for 30 minutes. In parallel, integrity was assessed after 5 cycles of decontamination using multiple US and international test methods, and the process was compared with the FDA-authorized vaporized hydrogen peroxide plus ozone (VHP+O-3) decontamination method. Results: Overall, MBL robustly and consistently inactivated all 3 coronaviruses with 99.8% to >99.9% virus inactivation across all FFRs and medical masks tested. FFR and medical mask integrity was maintained after 5 cycles of MBL treatment, whereas 1 FFR model failed after 5 cycles of VHP+O-3. Conclusions: MBL treatment decontaminated respirators and masks by inactivating 3 tested coronaviruses without compromising integrity through 5 cycles of decontamination. MBL decontamination is effective, is low cost, and does not require specialized equipment, making it applicable in low- to high-resource settings. |
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fullrecord | <record><control><sourceid>ghent</sourceid><recordid>TN_cdi_ghent_librecat_oai_archive_ugent_be_01GT1T530XZ6K37AFY0WQY1B8D</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>oai_archive_ugent_be_01GT1T530XZ6K37AFY0WQY1B8D</sourcerecordid><originalsourceid>FETCH-ghent_librecat_oai_archive_ugent_be_01GT1T530XZ6K37AFY0WQY1B8D3</originalsourceid><addsrcrecordid>eNqtT01PwkAQ7UET8eM_zBEOTVpqgXpDBElMDApR8dIs26EdbXfr7rSGv-yvcEEP_gAv85H35r15R14njOPEH4yiyxPv1Nq3IAiGSRJ2vK9xlhm0llQONRqrlSihNppRMrUI-NFQXaFi6C4W0x5kKLViUZESTFrBFVTIxa5EhbApGwShMigpLxgcZa8hGC1YbNE4UDaM4PxqMoK12YHUxlm2ZBoLP7UP3eX4celP9JPf74HzuE_iPzf2YFFhRtK9Wgn7buGTuHAjKUYllETQW9gvuSHeHfhb4nPveCtKixe__cybzqarydzPC5cvLWljUApOtaBUGFm4-GmT76ENpkF4uwpXcRS8vA7uouF4tg6eH9bh9egm-i-db2XPjoI</addsrcrecordid><sourcetype>Institutional Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Addressing personal protective equipment (PPE) decontamination : methylene blue and light inactivates severe acute respiratory coronavirus virus 2 (SARS-CoV-2) on N95 respirators and medical masks with maintenance of integrity and fit</title><source>ProQuest Central Essentials</source><source>Ghent University Academic Bibliography</source><source>Cambridge Journals Online</source><source>ProQuest Central (Alumni)</source><source>ProQuest Central UK/Ireland</source><source>ProQuest Central</source><creator>Lendvay, Thomas Sean ; Chen, James ; Harcourt, Brian H ; Scholte, Florine E. M ; Lin, Ying Ling ; Kilinc-Balci, F. Selcen ; Lamb, Molly M ; Homdayjanakul, Kamonthip ; Cui, Yi ; Price, Amy ; Heyne, Belinda ; Sahni, Jaya ; Kabra, Kareem B ; Lin, Yi-Chan ; Evans, David ; Mores, Christopher N ; Page, Ken ; Chu, Larry F ; Haubruge, Eric ; Thiry, Etienne ; Ludwig-Begall, Louisa F ; Wielick, Constance ; Clark, Tanner ; Wagner, Thor ; Timm, Emily ; Gallagher, Thomas ; Faris, Peter ; Macia, Nicolas ; Mackie, Cyrus J ; Simmons, Sarah M ; Reader, Susan ; Malott, Rebecca ; Hope, Karen ; Davies, Jan M ; Tritsch, Sarah R ; Dams, Lorene ; Nauwynck, Hans ; Willaert, Jean-Francois ; De Jaeger, Simon ; Liao, Lei ; Zhao, Mervin ; Laperre, Jan ; Jolois, Olivier ; Smit, Sarah J ; Patel, Alpa N ; Mayo, Mark ; Parker, Rod ; Molloy-Simard, Vanessa ; Lemyre, Jean-Luc ; Chu, Steven ; Conly, John M ; Chu, May C</creator><creatorcontrib>Lendvay, Thomas Sean ; Chen, James ; Harcourt, Brian H ; Scholte, Florine E. M ; Lin, Ying Ling ; Kilinc-Balci, F. Selcen ; Lamb, Molly M ; Homdayjanakul, Kamonthip ; Cui, Yi ; Price, Amy ; Heyne, Belinda ; Sahni, Jaya ; Kabra, Kareem B ; Lin, Yi-Chan ; Evans, David ; Mores, Christopher N ; Page, Ken ; Chu, Larry F ; Haubruge, Eric ; Thiry, Etienne ; Ludwig-Begall, Louisa F ; Wielick, Constance ; Clark, Tanner ; Wagner, Thor ; Timm, Emily ; Gallagher, Thomas ; Faris, Peter ; Macia, Nicolas ; Mackie, Cyrus J ; Simmons, Sarah M ; Reader, Susan ; Malott, Rebecca ; Hope, Karen ; Davies, Jan M ; Tritsch, Sarah R ; Dams, Lorene ; Nauwynck, Hans ; Willaert, Jean-Francois ; De Jaeger, Simon ; Liao, Lei ; Zhao, Mervin ; Laperre, Jan ; Jolois, Olivier ; Smit, Sarah J ; Patel, Alpa N ; Mayo, Mark ; Parker, Rod ; Molloy-Simard, Vanessa ; Lemyre, Jean-Luc ; Chu, Steven ; Conly, John M ; Chu, May C</creatorcontrib><description>Objective: The coronavirus disease 2019 (COVID-19) pandemic has resulted in shortages of personal protective equipment (PPE), underscoring the urgent need for simple, efficient, and inexpensive methods to decontaminate masks and respirators exposed to severe acute respiratory coronavirus virus 2 (SARS-CoV-2). We hypothesized that methylene blue (MB) photochemical treatment, which has various clinical applications, could decontaminate PPE contaminated with coronavirus. Design: The 2 arms of the study included (1) PPE inoculation with coronaviruses followed by MB with light (MBL) decontamination treatment and (2) PPE treatment with MBL for 5 cycles of decontamination to determine maintenance of PPE performance. Methods: MBL treatment was used to inactivate coronaviruses on 3 N95 filtering facepiece respirator (FFR) and 2 medical mask models. We inoculated FFR and medical mask materials with 3 coronaviruses, including SARS-CoV-2, and we treated them with 10 mu M MB and exposed them to 50,000 lux of white light or 12,500 lux of red light for 30 minutes. In parallel, integrity was assessed after 5 cycles of decontamination using multiple US and international test methods, and the process was compared with the FDA-authorized vaporized hydrogen peroxide plus ozone (VHP+O-3) decontamination method. Results: Overall, MBL robustly and consistently inactivated all 3 coronaviruses with 99.8% to >99.9% virus inactivation across all FFRs and medical masks tested. FFR and medical mask integrity was maintained after 5 cycles of MBL treatment, whereas 1 FFR model failed after 5 cycles of VHP+O-3. Conclusions: MBL treatment decontaminated respirators and masks by inactivating 3 tested coronaviruses without compromising integrity through 5 cycles of decontamination. MBL decontamination is effective, is low cost, and does not require specialized equipment, making it applicable in low- to high-resource settings.</description><identifier>ISSN: 1559-6834</identifier><identifier>ISSN: 0899-823X</identifier><language>eng</language><publisher>Cambridge Univ. Press</publisher><subject>EXTENDED USE ; IMPACT ; Medicine and Health Sciences ; PLASMA</subject><creationdate>2022</creationdate><rights>Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,315,780,784,4024,27860</link.rule.ids></links><search><creatorcontrib>Lendvay, Thomas Sean</creatorcontrib><creatorcontrib>Chen, James</creatorcontrib><creatorcontrib>Harcourt, Brian H</creatorcontrib><creatorcontrib>Scholte, Florine E. M</creatorcontrib><creatorcontrib>Lin, Ying Ling</creatorcontrib><creatorcontrib>Kilinc-Balci, F. Selcen</creatorcontrib><creatorcontrib>Lamb, Molly M</creatorcontrib><creatorcontrib>Homdayjanakul, Kamonthip</creatorcontrib><creatorcontrib>Cui, Yi</creatorcontrib><creatorcontrib>Price, Amy</creatorcontrib><creatorcontrib>Heyne, Belinda</creatorcontrib><creatorcontrib>Sahni, Jaya</creatorcontrib><creatorcontrib>Kabra, Kareem B</creatorcontrib><creatorcontrib>Lin, Yi-Chan</creatorcontrib><creatorcontrib>Evans, David</creatorcontrib><creatorcontrib>Mores, Christopher N</creatorcontrib><creatorcontrib>Page, Ken</creatorcontrib><creatorcontrib>Chu, Larry F</creatorcontrib><creatorcontrib>Haubruge, Eric</creatorcontrib><creatorcontrib>Thiry, Etienne</creatorcontrib><creatorcontrib>Ludwig-Begall, Louisa F</creatorcontrib><creatorcontrib>Wielick, Constance</creatorcontrib><creatorcontrib>Clark, Tanner</creatorcontrib><creatorcontrib>Wagner, Thor</creatorcontrib><creatorcontrib>Timm, Emily</creatorcontrib><creatorcontrib>Gallagher, Thomas</creatorcontrib><creatorcontrib>Faris, Peter</creatorcontrib><creatorcontrib>Macia, Nicolas</creatorcontrib><creatorcontrib>Mackie, Cyrus J</creatorcontrib><creatorcontrib>Simmons, Sarah M</creatorcontrib><creatorcontrib>Reader, Susan</creatorcontrib><creatorcontrib>Malott, Rebecca</creatorcontrib><creatorcontrib>Hope, Karen</creatorcontrib><creatorcontrib>Davies, Jan M</creatorcontrib><creatorcontrib>Tritsch, Sarah R</creatorcontrib><creatorcontrib>Dams, Lorene</creatorcontrib><creatorcontrib>Nauwynck, Hans</creatorcontrib><creatorcontrib>Willaert, Jean-Francois</creatorcontrib><creatorcontrib>De Jaeger, Simon</creatorcontrib><creatorcontrib>Liao, Lei</creatorcontrib><creatorcontrib>Zhao, Mervin</creatorcontrib><creatorcontrib>Laperre, Jan</creatorcontrib><creatorcontrib>Jolois, Olivier</creatorcontrib><creatorcontrib>Smit, Sarah J</creatorcontrib><creatorcontrib>Patel, Alpa N</creatorcontrib><creatorcontrib>Mayo, Mark</creatorcontrib><creatorcontrib>Parker, Rod</creatorcontrib><creatorcontrib>Molloy-Simard, Vanessa</creatorcontrib><creatorcontrib>Lemyre, Jean-Luc</creatorcontrib><creatorcontrib>Chu, Steven</creatorcontrib><creatorcontrib>Conly, John M</creatorcontrib><creatorcontrib>Chu, May C</creatorcontrib><title>Addressing personal protective equipment (PPE) decontamination : methylene blue and light inactivates severe acute respiratory coronavirus virus 2 (SARS-CoV-2) on N95 respirators and medical masks with maintenance of integrity and fit</title><description>Objective: The coronavirus disease 2019 (COVID-19) pandemic has resulted in shortages of personal protective equipment (PPE), underscoring the urgent need for simple, efficient, and inexpensive methods to decontaminate masks and respirators exposed to severe acute respiratory coronavirus virus 2 (SARS-CoV-2). We hypothesized that methylene blue (MB) photochemical treatment, which has various clinical applications, could decontaminate PPE contaminated with coronavirus. Design: The 2 arms of the study included (1) PPE inoculation with coronaviruses followed by MB with light (MBL) decontamination treatment and (2) PPE treatment with MBL for 5 cycles of decontamination to determine maintenance of PPE performance. Methods: MBL treatment was used to inactivate coronaviruses on 3 N95 filtering facepiece respirator (FFR) and 2 medical mask models. We inoculated FFR and medical mask materials with 3 coronaviruses, including SARS-CoV-2, and we treated them with 10 mu M MB and exposed them to 50,000 lux of white light or 12,500 lux of red light for 30 minutes. In parallel, integrity was assessed after 5 cycles of decontamination using multiple US and international test methods, and the process was compared with the FDA-authorized vaporized hydrogen peroxide plus ozone (VHP+O-3) decontamination method. Results: Overall, MBL robustly and consistently inactivated all 3 coronaviruses with 99.8% to >99.9% virus inactivation across all FFRs and medical masks tested. FFR and medical mask integrity was maintained after 5 cycles of MBL treatment, whereas 1 FFR model failed after 5 cycles of VHP+O-3. Conclusions: MBL treatment decontaminated respirators and masks by inactivating 3 tested coronaviruses without compromising integrity through 5 cycles of decontamination. MBL decontamination is effective, is low cost, and does not require specialized equipment, making it applicable in low- to high-resource settings.</description><subject>EXTENDED USE</subject><subject>IMPACT</subject><subject>Medicine and Health Sciences</subject><subject>PLASMA</subject><issn>1559-6834</issn><issn>0899-823X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ADGLB</sourceid><recordid>eNqtT01PwkAQ7UET8eM_zBEOTVpqgXpDBElMDApR8dIs26EdbXfr7rSGv-yvcEEP_gAv85H35r15R14njOPEH4yiyxPv1Nq3IAiGSRJ2vK9xlhm0llQONRqrlSihNppRMrUI-NFQXaFi6C4W0x5kKLViUZESTFrBFVTIxa5EhbApGwShMigpLxgcZa8hGC1YbNE4UDaM4PxqMoK12YHUxlm2ZBoLP7UP3eX4celP9JPf74HzuE_iPzf2YFFhRtK9Wgn7buGTuHAjKUYllETQW9gvuSHeHfhb4nPveCtKixe__cybzqarydzPC5cvLWljUApOtaBUGFm4-GmT76ENpkF4uwpXcRS8vA7uouF4tg6eH9bh9egm-i-db2XPjoI</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Lendvay, Thomas Sean</creator><creator>Chen, James</creator><creator>Harcourt, Brian H</creator><creator>Scholte, Florine E. M</creator><creator>Lin, Ying Ling</creator><creator>Kilinc-Balci, F. 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Selcen ; Lamb, Molly M ; Homdayjanakul, Kamonthip ; Cui, Yi ; Price, Amy ; Heyne, Belinda ; Sahni, Jaya ; Kabra, Kareem B ; Lin, Yi-Chan ; Evans, David ; Mores, Christopher N ; Page, Ken ; Chu, Larry F ; Haubruge, Eric ; Thiry, Etienne ; Ludwig-Begall, Louisa F ; Wielick, Constance ; Clark, Tanner ; Wagner, Thor ; Timm, Emily ; Gallagher, Thomas ; Faris, Peter ; Macia, Nicolas ; Mackie, Cyrus J ; Simmons, Sarah M ; Reader, Susan ; Malott, Rebecca ; Hope, Karen ; Davies, Jan M ; Tritsch, Sarah R ; Dams, Lorene ; Nauwynck, Hans ; Willaert, Jean-Francois ; De Jaeger, Simon ; Liao, Lei ; Zhao, Mervin ; Laperre, Jan ; Jolois, Olivier ; Smit, Sarah J ; Patel, Alpa N ; Mayo, Mark ; Parker, Rod ; Molloy-Simard, Vanessa ; Lemyre, Jean-Luc ; Chu, Steven ; Conly, John M ; Chu, May C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-ghent_librecat_oai_archive_ugent_be_01GT1T530XZ6K37AFY0WQY1B8D3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>EXTENDED USE</topic><topic>IMPACT</topic><topic>Medicine and Health Sciences</topic><topic>PLASMA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lendvay, Thomas Sean</creatorcontrib><creatorcontrib>Chen, James</creatorcontrib><creatorcontrib>Harcourt, Brian H</creatorcontrib><creatorcontrib>Scholte, Florine E. 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M</au><au>Lin, Ying Ling</au><au>Kilinc-Balci, F. Selcen</au><au>Lamb, Molly M</au><au>Homdayjanakul, Kamonthip</au><au>Cui, Yi</au><au>Price, Amy</au><au>Heyne, Belinda</au><au>Sahni, Jaya</au><au>Kabra, Kareem B</au><au>Lin, Yi-Chan</au><au>Evans, David</au><au>Mores, Christopher N</au><au>Page, Ken</au><au>Chu, Larry F</au><au>Haubruge, Eric</au><au>Thiry, Etienne</au><au>Ludwig-Begall, Louisa F</au><au>Wielick, Constance</au><au>Clark, Tanner</au><au>Wagner, Thor</au><au>Timm, Emily</au><au>Gallagher, Thomas</au><au>Faris, Peter</au><au>Macia, Nicolas</au><au>Mackie, Cyrus J</au><au>Simmons, Sarah M</au><au>Reader, Susan</au><au>Malott, Rebecca</au><au>Hope, Karen</au><au>Davies, Jan M</au><au>Tritsch, Sarah R</au><au>Dams, Lorene</au><au>Nauwynck, Hans</au><au>Willaert, Jean-Francois</au><au>De Jaeger, Simon</au><au>Liao, Lei</au><au>Zhao, Mervin</au><au>Laperre, Jan</au><au>Jolois, Olivier</au><au>Smit, Sarah J</au><au>Patel, Alpa N</au><au>Mayo, Mark</au><au>Parker, Rod</au><au>Molloy-Simard, Vanessa</au><au>Lemyre, Jean-Luc</au><au>Chu, Steven</au><au>Conly, John M</au><au>Chu, May C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Addressing personal protective equipment (PPE) decontamination : methylene blue and light inactivates severe acute respiratory coronavirus virus 2 (SARS-CoV-2) on N95 respirators and medical masks with maintenance of integrity and fit</atitle><date>2022</date><risdate>2022</risdate><issn>1559-6834</issn><issn>0899-823X</issn><abstract>Objective: The coronavirus disease 2019 (COVID-19) pandemic has resulted in shortages of personal protective equipment (PPE), underscoring the urgent need for simple, efficient, and inexpensive methods to decontaminate masks and respirators exposed to severe acute respiratory coronavirus virus 2 (SARS-CoV-2). We hypothesized that methylene blue (MB) photochemical treatment, which has various clinical applications, could decontaminate PPE contaminated with coronavirus. Design: The 2 arms of the study included (1) PPE inoculation with coronaviruses followed by MB with light (MBL) decontamination treatment and (2) PPE treatment with MBL for 5 cycles of decontamination to determine maintenance of PPE performance. Methods: MBL treatment was used to inactivate coronaviruses on 3 N95 filtering facepiece respirator (FFR) and 2 medical mask models. We inoculated FFR and medical mask materials with 3 coronaviruses, including SARS-CoV-2, and we treated them with 10 mu M MB and exposed them to 50,000 lux of white light or 12,500 lux of red light for 30 minutes. In parallel, integrity was assessed after 5 cycles of decontamination using multiple US and international test methods, and the process was compared with the FDA-authorized vaporized hydrogen peroxide plus ozone (VHP+O-3) decontamination method. Results: Overall, MBL robustly and consistently inactivated all 3 coronaviruses with 99.8% to >99.9% virus inactivation across all FFRs and medical masks tested. FFR and medical mask integrity was maintained after 5 cycles of MBL treatment, whereas 1 FFR model failed after 5 cycles of VHP+O-3. Conclusions: MBL treatment decontaminated respirators and masks by inactivating 3 tested coronaviruses without compromising integrity through 5 cycles of decontamination. MBL decontamination is effective, is low cost, and does not require specialized equipment, making it applicable in low- to high-resource settings.</abstract><pub>Cambridge Univ. Press</pub><oa>free_for_read</oa></addata></record> |
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source | ProQuest Central Essentials; Ghent University Academic Bibliography; Cambridge Journals Online; ProQuest Central (Alumni); ProQuest Central UK/Ireland; ProQuest Central |
subjects | EXTENDED USE IMPACT Medicine and Health Sciences PLASMA |
title | Addressing personal protective equipment (PPE) decontamination : methylene blue and light inactivates severe acute respiratory coronavirus virus 2 (SARS-CoV-2) on N95 respirators and medical masks with maintenance of integrity and fit |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T08%3A05%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-ghent&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Addressing%20personal%20protective%20equipment%20(PPE)%20decontamination%20:%20methylene%20blue%20and%20light%20inactivates%20severe%20acute%20respiratory%20coronavirus%20virus%202%20(SARS-CoV-2)%20on%20N95%20respirators%20and%20medical%20masks%20with%20maintenance%20of%20integrity%20and%20fit&rft.au=Lendvay,%20Thomas%20Sean&rft.date=2022&rft.issn=1559-6834&rft_id=info:doi/&rft_dat=%3Cghent%3Eoai_archive_ugent_be_01GT1T530XZ6K37AFY0WQY1B8D%3C/ghent%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |