A novel USP4 inhibitor that suppresses colorectal cancer stemness by promoting [beta]-catenin and Twist1 degradation

Background The high mortality rate of metastatic colorectal cancer (CRC) is primarily attributed to resistance to chemotherapy, where cancer stem cells (CSCs) play a crucial role. Deubiquitinating enzymes are essential regulators of CSC maintenance, making them potential targets for eliminating CSCs...

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Veröffentlicht in:	Journal of translational medicine 2025-01, Vol.23 (1)
Hauptverfasser:	Li, Fengtian, Zhou, Yi, Lin, Xinyue, Zhang, Yaxin, Hu, Qingyong, Zhao, Enen, Li, Huali, Pan, Xingyan, Shu, Feng, Zhang, Kun, Huang, Chengmei, Tang, Na, Liao, Wenting
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Colorectal cancer Development and progression Drug resistance Drug therapy Genetic aspects Health aspects Metastasis Oncology, Experimental Protease inhibitors Proteolysis Testing Transcription factors
Online-Zugang:	Volltext
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