FACILE SYNTHESIS OF THIOPHENE-EMBEDDED BAICALEIN VIA OXIDATIVE CYCLIZATION AND ANTICANCER ACTIVITY AGAINST OVARIAN CANCER CELLS VIA INHIBITING PI3K/MTOR SIGNALING PATHWAY: IN-VITRO AND IN-SILICO STUDY

This study illustrated the synthesis of a thiophene-embedded Baicalein (BAC) conjugate through the formation of a chalcone backbone, accomplished by refluxing hydroxyl-acetophenone with 5-nitrothiophene-2-carbaldehyde in the presence of piperidine. The BAC conjugate (5,6,7-trihydroxy-2-(5-nitrothiop...

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Veröffentlicht in:	Bulletin of the Chemical Society of Ethiopia 2025-05, Vol.39 (2), p.367
Hauptverfasser:	Liu, Zheqi, Zeng, Lin, Wu, Linshan, Song, Daping, Chen, Yanhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cancer Cancer cells Care and treatment Oncology, Experimental Ovarian cancer RNA Thiophene
Online-Zugang:	Volltext
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