Impact of Early Initiation of Appropriate Antibiotic Therapy on Outcome of Bloodstream Infections/Kan Dolasimi Infeksiyonlarinda Uygun Antibiyotik Tedavisine Erken Baslanmasinin Prognoza Etkisi
Objective: Bloodstream infections (BSIs) remain a leading cause of morbidity and mortality. We aimed to evaluate the appropriateness of empiric antimicrobial treatment in patients with BSI and its effect on mortality and hospital stay. Methods: 100 BSI-diagnosed patients aged 18 and older were inclu...
Gespeichert in:
| Veröffentlicht in: | KLIMIK dergisi 2024-09, Vol.37 (3), p.187 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 3 |
| container_start_page | 187 |
| container_title | KLIMIK dergisi |
| container_volume | 37 |
| creator | Kazci, Saliha Araz, Halime Mumcuoglu, Ipek Dokuzoguz, Basak |
| description | Objective: Bloodstream infections (BSIs) remain a leading cause of morbidity and mortality. We aimed to evaluate the appropriateness of empiric antimicrobial treatment in patients with BSI and its effect on mortality and hospital stay. Methods: 100 BSI-diagnosed patients aged 18 and older were included in the study. Sociodemographic characteristics, clinical and microbiological data, empirically initiated treatments, time to appropriate treatment, 10th-day (early period) and hospital discharge mortality rates, and lengths of hospital stay were recorded. Data were analyzed using Pearson [chi square], Fisher's exact test, trend [chi square] test, and Mann-Whitney U test. Logistic regression assessed the impact on mortality, with p |
| doi_str_mv | 10.36519/kd.2024.4958 |
| format | Article |
| fullrecord | <record><control><sourceid>gale</sourceid><recordid>TN_cdi_gale_infotracmisc_A811713623</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A811713623</galeid><sourcerecordid>A811713623</sourcerecordid><originalsourceid>FETCH-LOGICAL-g673-a8beeabd7c5a1334ed5f38f2e329bfc8786b6ae66e1066c52d55bae524b379d33</originalsourceid><addsrcrecordid>eNptjLFOwzAQQDOABAJGdkvMLXEcO-lYoEAFEgxFYkMX-1KOJHZkG6Twd_wZCXRg4G446endS5JTns6Fknxx3ph5lmb5PF_Ici855CLlM56L54PkJIS3dJoiLXJ5mHytux50ZK5mK_DtwNaWIkEkZye27Hvvej8CZEsbqSIXSbPNK3roBzZKD-9Ruw4n-aJ1zoToEboxU6OeKuH8Diy7ci0E6uiHN4EGZ1vwZA2wp2H7bnfxYaw3bIMGPiiQRbbyDVp2AaEF240FS5Y9ere17hPYKjajdZzs19AGPNndo2Rzvdpc3s7uH27Wl8v72VYVYgZlhQiVKbQELkSORtairDMU2aKqdVmUqlKASiFPldIyM1JWgDLLK1EsjBBHydlvdgstvpCtXfSgOwr6ZVlyXnChssma_2ONa7Aj7SzWNPI_D9_JaYpF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Impact of Early Initiation of Appropriate Antibiotic Therapy on Outcome of Bloodstream Infections/Kan Dolasimi Infeksiyonlarinda Uygun Antibiyotik Tedavisine Erken Baslanmasinin Prognoza Etkisi</title><source>EZB Electronic Journals Library</source><creator>Kazci, Saliha ; Araz, Halime ; Mumcuoglu, Ipek ; Dokuzoguz, Basak</creator><creatorcontrib>Kazci, Saliha ; Araz, Halime ; Mumcuoglu, Ipek ; Dokuzoguz, Basak</creatorcontrib><description>Objective: Bloodstream infections (BSIs) remain a leading cause of morbidity and mortality. We aimed to evaluate the appropriateness of empiric antimicrobial treatment in patients with BSI and its effect on mortality and hospital stay. Methods: 100 BSI-diagnosed patients aged 18 and older were included in the study. Sociodemographic characteristics, clinical and microbiological data, empirically initiated treatments, time to appropriate treatment, 10th-day (early period) and hospital discharge mortality rates, and lengths of hospital stay were recorded. Data were analyzed using Pearson [chi square], Fisher's exact test, trend [chi square] test, and Mann-Whitney U test. Logistic regression assessed the impact on mortality, with p <0.05 considered statistically significant. Results: 51% of cases were female, and the median age was 64 (min-max=19-94). No significant difference was found between appropriate and inappropriate antibiotic treatment groups in age, sex, clinical severity, Charlson comorbidity index (CCI) scores, and microorganism distribution. However, multidrug-resistant organisms were significantly more common in the inappropriate empiric treatment group (p=0.001). Of all BSIs, 57% were hospital-acquired, and 43% were community-onset, with primary BSIs accounting for 55%. No significant difference was found between the groups in terms of where BSI was acquired and its source. Empiric treatment appropriateness was 57%, with resistance among microorganisms being the main factor in inappropriate treatment. Early period (10th-day) mortality was 26%, and hospital discharge mortality was 41%, with no significant association found between the empiric treatment, appropriateness, time to appropriate treatment, and mortality. However, inappropriate empiric treatment was significantly associated with higher hospital discharge mortality (p=0.033) in immunocompetent patients. Hospital stay was significantly shorter in the appropriate empiric treatment group compared to the inappropriate group (p=0.035). Conclusion: We did not find significant impact of the appropriateness of antimicrobial treatment and time to appropriate treatment on mortality but appropriate treatment significantly shortened hospital stays. Keywords: bloodstream infection, mortality, appropriate empiric antibiotic treatment, duration of hospitalization. Amac: Kan dolasimi infeksiyonlari (KDI'ler) onde gelen morbidite ve mortalite nedenlerinden biri olmaya devam etmektedir. Calismamizda KDI olan hastalarda baslanan ampirik antimikrobiyal tedavilerin uygunlugu, erken ve uygun antimikrobiyal tedavinin mortalite ve hastanede kalis suresi uzerine etkisi arastirildi. Yontemler: Calismaya, KDI tanisi konan, 18 yas ve uzeri 100 hasta dahil edildi. Hastalarin sosyodemografik ozellikleri, klinik ve mikrobiyolojik verileri, ampirik baslanan tedavileri, uygun tedaviye kadar gecen sureleri, 10. gun (erken donem) ile hastane yatis sonu mortaliteleri ve hastanede kalis sureleri kaydedildi. Verilerin analizinde; Pearson [chi square], Fisher'in kesin testi, egilim ("trend") icin [chi square] testi, Mann-Whitney U testi kullanildi. Degiskenlerin mortaliteye etkisi lojistik regresyon analizi ile degerlendirildi ve p <0.05 istatistiksel anlamli duzey olarak kabul edildi. Bulgular: Hastalarin medyan yasi 64 (min.-mak.=19-94) yil olup %51'i kadindi. Ampirik tedavisi uygun olan ve olmayan gruplar arasinda; yas, cinsiyet, takip eden klinik ve Charlson komorbidite indeksi (CCI)'ne gore komorbidite derecesi ve mevcut klinik siddeti acisindan anlamli duzeyde fark saptanmadi; mikroorganizma dagilimi acisindan da anlam duzeyde fark tespit edilmedi ancak ampirik tedavisi uygun olmayan hastalarda cok ilac direncli etkenler istatistiksel olarak anlamli duzeydeydi (p=0.001). Tespit edilen KDI'lerin %57'si hastane kaynakli, %43'u toplum baslangicli idi; primer KDI'lerin orani %55'ti. Ampirik tedavi uygunluguna gore iki grup arasinda, KDI kazanim yeri ve kaynagi acisindan fark yoktu. Ampirik tedavi uygunlugu %57 olarak tespit edildi. Uygun olmayan ampirik tedavide ana faktor etken mikroorganizmalardaki direncti. Erken donem (10. gun) mortalite %26, hastane yatis sonu mortalite %41 olup ampirik tedavi uygunlugu ve uygun tedaviye kadar gecen sure ile mortalite arasinda anlamli iliski saptanmadi. Yalnizca immunokompetan kisilerde ampirik tedavi uygun baslanmadiginda hastane yatis sonu mortalite anlamli duzeyde daha yuksek bulundu (p=0.033). Ampirik tedavisi uygun olan hastalarin hastanede kalis suresi uygun olmayanlarin kalis suresinden anlamli duzeyde kisa idi (p=0.035). Sonuc: Calismamizda, antimikrobiyal tedavi uygunlugunun ve uygun tedaviye kadar gecen surenin mortalite uzerine etkisi bulunmamis iken hastanede kalis suresini anlamli sekilde kisalttigi tespit edildi. Anahtar kelimeler: kan dolasimi infeksiyonu, mortalite, uygun ampirik tedavi</description><identifier>ISSN: 1301-143X</identifier><identifier>DOI: 10.36519/kd.2024.4958</identifier><language>eng</language><publisher>DOC Design and Informatics Co. Ltd</publisher><subject>Antibiotics ; Care and treatment ; Comorbidity ; Drug resistance in microorganisms ; Health aspects ; Infection ; Mortality</subject><ispartof>KLIMIK dergisi, 2024-09, Vol.37 (3), p.187</ispartof><rights>COPYRIGHT 2024 DOC Design and Informatics Co. Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Kazci, Saliha</creatorcontrib><creatorcontrib>Araz, Halime</creatorcontrib><creatorcontrib>Mumcuoglu, Ipek</creatorcontrib><creatorcontrib>Dokuzoguz, Basak</creatorcontrib><title>Impact of Early Initiation of Appropriate Antibiotic Therapy on Outcome of Bloodstream Infections/Kan Dolasimi Infeksiyonlarinda Uygun Antibiyotik Tedavisine Erken Baslanmasinin Prognoza Etkisi</title><title>KLIMIK dergisi</title><description>Objective: Bloodstream infections (BSIs) remain a leading cause of morbidity and mortality. We aimed to evaluate the appropriateness of empiric antimicrobial treatment in patients with BSI and its effect on mortality and hospital stay. Methods: 100 BSI-diagnosed patients aged 18 and older were included in the study. Sociodemographic characteristics, clinical and microbiological data, empirically initiated treatments, time to appropriate treatment, 10th-day (early period) and hospital discharge mortality rates, and lengths of hospital stay were recorded. Data were analyzed using Pearson [chi square], Fisher's exact test, trend [chi square] test, and Mann-Whitney U test. Logistic regression assessed the impact on mortality, with p <0.05 considered statistically significant. Results: 51% of cases were female, and the median age was 64 (min-max=19-94). No significant difference was found between appropriate and inappropriate antibiotic treatment groups in age, sex, clinical severity, Charlson comorbidity index (CCI) scores, and microorganism distribution. However, multidrug-resistant organisms were significantly more common in the inappropriate empiric treatment group (p=0.001). Of all BSIs, 57% were hospital-acquired, and 43% were community-onset, with primary BSIs accounting for 55%. No significant difference was found between the groups in terms of where BSI was acquired and its source. Empiric treatment appropriateness was 57%, with resistance among microorganisms being the main factor in inappropriate treatment. Early period (10th-day) mortality was 26%, and hospital discharge mortality was 41%, with no significant association found between the empiric treatment, appropriateness, time to appropriate treatment, and mortality. However, inappropriate empiric treatment was significantly associated with higher hospital discharge mortality (p=0.033) in immunocompetent patients. Hospital stay was significantly shorter in the appropriate empiric treatment group compared to the inappropriate group (p=0.035). Conclusion: We did not find significant impact of the appropriateness of antimicrobial treatment and time to appropriate treatment on mortality but appropriate treatment significantly shortened hospital stays. Keywords: bloodstream infection, mortality, appropriate empiric antibiotic treatment, duration of hospitalization. Amac: Kan dolasimi infeksiyonlari (KDI'ler) onde gelen morbidite ve mortalite nedenlerinden biri olmaya devam etmektedir. Calismamizda KDI olan hastalarda baslanan ampirik antimikrobiyal tedavilerin uygunlugu, erken ve uygun antimikrobiyal tedavinin mortalite ve hastanede kalis suresi uzerine etkisi arastirildi. Yontemler: Calismaya, KDI tanisi konan, 18 yas ve uzeri 100 hasta dahil edildi. Hastalarin sosyodemografik ozellikleri, klinik ve mikrobiyolojik verileri, ampirik baslanan tedavileri, uygun tedaviye kadar gecen sureleri, 10. gun (erken donem) ile hastane yatis sonu mortaliteleri ve hastanede kalis sureleri kaydedildi. Verilerin analizinde; Pearson [chi square], Fisher'in kesin testi, egilim ("trend") icin [chi square] testi, Mann-Whitney U testi kullanildi. Degiskenlerin mortaliteye etkisi lojistik regresyon analizi ile degerlendirildi ve p <0.05 istatistiksel anlamli duzey olarak kabul edildi. Bulgular: Hastalarin medyan yasi 64 (min.-mak.=19-94) yil olup %51'i kadindi. Ampirik tedavisi uygun olan ve olmayan gruplar arasinda; yas, cinsiyet, takip eden klinik ve Charlson komorbidite indeksi (CCI)'ne gore komorbidite derecesi ve mevcut klinik siddeti acisindan anlamli duzeyde fark saptanmadi; mikroorganizma dagilimi acisindan da anlam duzeyde fark tespit edilmedi ancak ampirik tedavisi uygun olmayan hastalarda cok ilac direncli etkenler istatistiksel olarak anlamli duzeydeydi (p=0.001). Tespit edilen KDI'lerin %57'si hastane kaynakli, %43'u toplum baslangicli idi; primer KDI'lerin orani %55'ti. Ampirik tedavi uygunluguna gore iki grup arasinda, KDI kazanim yeri ve kaynagi acisindan fark yoktu. Ampirik tedavi uygunlugu %57 olarak tespit edildi. Uygun olmayan ampirik tedavide ana faktor etken mikroorganizmalardaki direncti. Erken donem (10. gun) mortalite %26, hastane yatis sonu mortalite %41 olup ampirik tedavi uygunlugu ve uygun tedaviye kadar gecen sure ile mortalite arasinda anlamli iliski saptanmadi. Yalnizca immunokompetan kisilerde ampirik tedavi uygun baslanmadiginda hastane yatis sonu mortalite anlamli duzeyde daha yuksek bulundu (p=0.033). Ampirik tedavisi uygun olan hastalarin hastanede kalis suresi uygun olmayanlarin kalis suresinden anlamli duzeyde kisa idi (p=0.035). Sonuc: Calismamizda, antimikrobiyal tedavi uygunlugunun ve uygun tedaviye kadar gecen surenin mortalite uzerine etkisi bulunmamis iken hastanede kalis suresini anlamli sekilde kisalttigi tespit edildi. Anahtar kelimeler: kan dolasimi infeksiyonu, mortalite, uygun ampirik tedavi</description><subject>Antibiotics</subject><subject>Care and treatment</subject><subject>Comorbidity</subject><subject>Drug resistance in microorganisms</subject><subject>Health aspects</subject><subject>Infection</subject><subject>Mortality</subject><issn>1301-143X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptjLFOwzAQQDOABAJGdkvMLXEcO-lYoEAFEgxFYkMX-1KOJHZkG6Twd_wZCXRg4G446endS5JTns6Fknxx3ph5lmb5PF_Ici855CLlM56L54PkJIS3dJoiLXJ5mHytux50ZK5mK_DtwNaWIkEkZye27Hvvej8CZEsbqSIXSbPNK3roBzZKD-9Ruw4n-aJ1zoToEboxU6OeKuH8Diy7ci0E6uiHN4EGZ1vwZA2wp2H7bnfxYaw3bIMGPiiQRbbyDVp2AaEF240FS5Y9ere17hPYKjajdZzs19AGPNndo2Rzvdpc3s7uH27Wl8v72VYVYgZlhQiVKbQELkSORtairDMU2aKqdVmUqlKASiFPldIyM1JWgDLLK1EsjBBHydlvdgstvpCtXfSgOwr6ZVlyXnChssma_2ONa7Aj7SzWNPI_D9_JaYpF</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Kazci, Saliha</creator><creator>Araz, Halime</creator><creator>Mumcuoglu, Ipek</creator><creator>Dokuzoguz, Basak</creator><general>DOC Design and Informatics Co. Ltd</general><scope/></search><sort><creationdate>20240901</creationdate><title>Impact of Early Initiation of Appropriate Antibiotic Therapy on Outcome of Bloodstream Infections/Kan Dolasimi Infeksiyonlarinda Uygun Antibiyotik Tedavisine Erken Baslanmasinin Prognoza Etkisi</title><author>Kazci, Saliha ; Araz, Halime ; Mumcuoglu, Ipek ; Dokuzoguz, Basak</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g673-a8beeabd7c5a1334ed5f38f2e329bfc8786b6ae66e1066c52d55bae524b379d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Antibiotics</topic><topic>Care and treatment</topic><topic>Comorbidity</topic><topic>Drug resistance in microorganisms</topic><topic>Health aspects</topic><topic>Infection</topic><topic>Mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kazci, Saliha</creatorcontrib><creatorcontrib>Araz, Halime</creatorcontrib><creatorcontrib>Mumcuoglu, Ipek</creatorcontrib><creatorcontrib>Dokuzoguz, Basak</creatorcontrib><jtitle>KLIMIK dergisi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kazci, Saliha</au><au>Araz, Halime</au><au>Mumcuoglu, Ipek</au><au>Dokuzoguz, Basak</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Early Initiation of Appropriate Antibiotic Therapy on Outcome of Bloodstream Infections/Kan Dolasimi Infeksiyonlarinda Uygun Antibiyotik Tedavisine Erken Baslanmasinin Prognoza Etkisi</atitle><jtitle>KLIMIK dergisi</jtitle><date>2024-09-01</date><risdate>2024</risdate><volume>37</volume><issue>3</issue><spage>187</spage><pages>187-</pages><issn>1301-143X</issn><abstract>Objective: Bloodstream infections (BSIs) remain a leading cause of morbidity and mortality. We aimed to evaluate the appropriateness of empiric antimicrobial treatment in patients with BSI and its effect on mortality and hospital stay. Methods: 100 BSI-diagnosed patients aged 18 and older were included in the study. Sociodemographic characteristics, clinical and microbiological data, empirically initiated treatments, time to appropriate treatment, 10th-day (early period) and hospital discharge mortality rates, and lengths of hospital stay were recorded. Data were analyzed using Pearson [chi square], Fisher's exact test, trend [chi square] test, and Mann-Whitney U test. Logistic regression assessed the impact on mortality, with p <0.05 considered statistically significant. Results: 51% of cases were female, and the median age was 64 (min-max=19-94). No significant difference was found between appropriate and inappropriate antibiotic treatment groups in age, sex, clinical severity, Charlson comorbidity index (CCI) scores, and microorganism distribution. However, multidrug-resistant organisms were significantly more common in the inappropriate empiric treatment group (p=0.001). Of all BSIs, 57% were hospital-acquired, and 43% were community-onset, with primary BSIs accounting for 55%. No significant difference was found between the groups in terms of where BSI was acquired and its source. Empiric treatment appropriateness was 57%, with resistance among microorganisms being the main factor in inappropriate treatment. Early period (10th-day) mortality was 26%, and hospital discharge mortality was 41%, with no significant association found between the empiric treatment, appropriateness, time to appropriate treatment, and mortality. However, inappropriate empiric treatment was significantly associated with higher hospital discharge mortality (p=0.033) in immunocompetent patients. Hospital stay was significantly shorter in the appropriate empiric treatment group compared to the inappropriate group (p=0.035). Conclusion: We did not find significant impact of the appropriateness of antimicrobial treatment and time to appropriate treatment on mortality but appropriate treatment significantly shortened hospital stays. Keywords: bloodstream infection, mortality, appropriate empiric antibiotic treatment, duration of hospitalization. Amac: Kan dolasimi infeksiyonlari (KDI'ler) onde gelen morbidite ve mortalite nedenlerinden biri olmaya devam etmektedir. Calismamizda KDI olan hastalarda baslanan ampirik antimikrobiyal tedavilerin uygunlugu, erken ve uygun antimikrobiyal tedavinin mortalite ve hastanede kalis suresi uzerine etkisi arastirildi. Yontemler: Calismaya, KDI tanisi konan, 18 yas ve uzeri 100 hasta dahil edildi. Hastalarin sosyodemografik ozellikleri, klinik ve mikrobiyolojik verileri, ampirik baslanan tedavileri, uygun tedaviye kadar gecen sureleri, 10. gun (erken donem) ile hastane yatis sonu mortaliteleri ve hastanede kalis sureleri kaydedildi. Verilerin analizinde; Pearson [chi square], Fisher'in kesin testi, egilim ("trend") icin [chi square] testi, Mann-Whitney U testi kullanildi. Degiskenlerin mortaliteye etkisi lojistik regresyon analizi ile degerlendirildi ve p <0.05 istatistiksel anlamli duzey olarak kabul edildi. Bulgular: Hastalarin medyan yasi 64 (min.-mak.=19-94) yil olup %51'i kadindi. Ampirik tedavisi uygun olan ve olmayan gruplar arasinda; yas, cinsiyet, takip eden klinik ve Charlson komorbidite indeksi (CCI)'ne gore komorbidite derecesi ve mevcut klinik siddeti acisindan anlamli duzeyde fark saptanmadi; mikroorganizma dagilimi acisindan da anlam duzeyde fark tespit edilmedi ancak ampirik tedavisi uygun olmayan hastalarda cok ilac direncli etkenler istatistiksel olarak anlamli duzeydeydi (p=0.001). Tespit edilen KDI'lerin %57'si hastane kaynakli, %43'u toplum baslangicli idi; primer KDI'lerin orani %55'ti. Ampirik tedavi uygunluguna gore iki grup arasinda, KDI kazanim yeri ve kaynagi acisindan fark yoktu. Ampirik tedavi uygunlugu %57 olarak tespit edildi. Uygun olmayan ampirik tedavide ana faktor etken mikroorganizmalardaki direncti. Erken donem (10. gun) mortalite %26, hastane yatis sonu mortalite %41 olup ampirik tedavi uygunlugu ve uygun tedaviye kadar gecen sure ile mortalite arasinda anlamli iliski saptanmadi. Yalnizca immunokompetan kisilerde ampirik tedavi uygun baslanmadiginda hastane yatis sonu mortalite anlamli duzeyde daha yuksek bulundu (p=0.033). Ampirik tedavisi uygun olan hastalarin hastanede kalis suresi uygun olmayanlarin kalis suresinden anlamli duzeyde kisa idi (p=0.035). Sonuc: Calismamizda, antimikrobiyal tedavi uygunlugunun ve uygun tedaviye kadar gecen surenin mortalite uzerine etkisi bulunmamis iken hastanede kalis suresini anlamli sekilde kisalttigi tespit edildi. Anahtar kelimeler: kan dolasimi infeksiyonu, mortalite, uygun ampirik tedavi</abstract><pub>DOC Design and Informatics Co. Ltd</pub><doi>10.36519/kd.2024.4958</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1301-143X |
| ispartof | KLIMIK dergisi, 2024-09, Vol.37 (3), p.187 |
| issn | 1301-143X |
| language | eng |
| recordid | cdi_gale_infotracmisc_A811713623 |
| source | EZB Electronic Journals Library |
| subjects | Antibiotics Care and treatment Comorbidity Drug resistance in microorganisms Health aspects Infection Mortality |
| title | Impact of Early Initiation of Appropriate Antibiotic Therapy on Outcome of Bloodstream Infections/Kan Dolasimi Infeksiyonlarinda Uygun Antibiyotik Tedavisine Erken Baslanmasinin Prognoza Etkisi |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T07%3A18%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20Early%20Initiation%20of%20Appropriate%20Antibiotic%20Therapy%20on%20Outcome%20of%20Bloodstream%20Infections/Kan%20Dolasimi%20Infeksiyonlarinda%20Uygun%20Antibiyotik%20Tedavisine%20Erken%20Baslanmasinin%20Prognoza%20Etkisi&rft.jtitle=KLIMIK%20dergisi&rft.au=Kazci,%20Saliha&rft.date=2024-09-01&rft.volume=37&rft.issue=3&rft.spage=187&rft.pages=187-&rft.issn=1301-143X&rft_id=info:doi/10.36519/kd.2024.4958&rft_dat=%3Cgale%3EA811713623%3C/gale%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_galeid=A811713623&rfr_iscdi=true |