PD1CD28 chimeric molecule enhances EGFRv⢠specific CAR-T cells in xenograft experiments in mouse models

Over the years, CAR-T cell therapy has achieved remarkable success in treating hematological malignancies. However, this efficacy has not been replicated in the context of glioblastoma (GBM). In this study, a PD1CD28 chimeric molecule was introduced into EGFRvâ¢-directed CAR-T cells, generating EGFR...

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Veröffentlicht in:	PloS one 2024-10, Vol.19 (10), p.e0310430
Hauptverfasser:	Chen, Wanqiong, Xian, Na, Zhao, Ningning, Zhang, Qiong, Xu, Yunlu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal experimentation Antigens Apoptosis Care and treatment Glioblastoma multiforme Gliomas Patient outcomes T cells
Online-Zugang:	Volltext
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