Health conditions of first-degree relatives of children with familial Mediterranean fever
Given the strong genetic background of familial Mediterranean fever (FMF), the frequently reported co-existing diseases in children with FMF should also be investigated in other family members. Therefore, we aimed to examine the medical conditions of first-degree relatives (FDRs) of our pediatric pa...
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| Veröffentlicht in: | The Turkish journal of pediatrics 2024-05, Vol.66 (2), p.180-190 |
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| container_title | The Turkish journal of pediatrics |
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| creator | Yıldırım, Sema Haşlak, Fatih Yıldız, Mehmet Adrovic, Amra Aliyeva, Ayten Günalp, Aybüke Aslan, Esma Kılıç Könte, Elif Gül, Ümit Şahin, Sezgin Barut, Kenan Kasapçopur, Özgür |
| description | Given the strong genetic background of familial Mediterranean fever (FMF), the frequently reported co-existing diseases in children with FMF should also be investigated in other family members. Therefore, we aimed to examine the medical conditions of first-degree relatives (FDRs) of our pediatric patients with FMF in the present study.
Chronic diseases of FDRs of pediatric 449 FMF, 147 juvenile idiopathic arthritis (JIA) patients and 93 healthy controls (HC) were questioned during their routine clinical visits for 9 consecutive months.
A total of 1975 FDRs of 449 FMF, 690 FDRs of 147 JIA patients, and 406 FDRs of 93 HC were included into the study. The most common medical conditions were non-atopic asthma (n=71, 3.6%), type 2 DM (n=14, 2%), and tonsillectomy history (n=12, 2.95%) in the FMF, JIA, and HC groups, respectively. Atopic diseases (FMF vs. JIA: p=0.013; FMF vs. HC: p=0.014), rheumatic diseases (FMF vs. JIA: p=0.030; FMF vs. HC: p=0.017), and surgical histories (FMF vs. JIA: p |
| doi_str_mv | 10.24953/turkjpediatr.2024.4589 |
| format | Article |
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Chronic diseases of FDRs of pediatric 449 FMF, 147 juvenile idiopathic arthritis (JIA) patients and 93 healthy controls (HC) were questioned during their routine clinical visits for 9 consecutive months.
A total of 1975 FDRs of 449 FMF, 690 FDRs of 147 JIA patients, and 406 FDRs of 93 HC were included into the study. The most common medical conditions were non-atopic asthma (n=71, 3.6%), type 2 DM (n=14, 2%), and tonsillectomy history (n=12, 2.95%) in the FMF, JIA, and HC groups, respectively. Atopic diseases (FMF vs. JIA: p=0.013; FMF vs. HC: p=0.014), rheumatic diseases (FMF vs. JIA: p=0.030; FMF vs. HC: p=0.017), and surgical histories (FMF vs. JIA: p<0.01; FMF vs. HC: p=0.026), including adenoidectomy, tonsillectomy, and appendectomy, were significantly more common in the FMF group than in other groups.
Our novel findings may contribute to understanding the hereditary burden of co-existing diseases in children with FMF and encourage further studies involving genetic screenings.</description><identifier>ISSN: 0041-4301</identifier><identifier>EISSN: 2791-6421</identifier><identifier>DOI: 10.24953/turkjpediatr.2024.4589</identifier><identifier>PMID: 38814299</identifier><language>eng</language><publisher>Turkey: Akdema Informatics and Publishing</publisher><subject>Adolescent ; Adult ; Arthritis ; Arthritis, Juvenile - epidemiology ; Arthritis, Juvenile - genetics ; Asthma - epidemiology ; Asthma - genetics ; Case-Control Studies ; Child ; Child, Preschool ; Children ; Chronic diseases ; Familial Mediterranean fever ; Familial Mediterranean Fever - epidemiology ; Familial Mediterranean Fever - genetics ; Family ; Female ; Genetic aspects ; Genetic screening ; Health aspects ; Humans ; Male ; Medical research ; Medicine, Experimental ; Pediatrics ; Tonsillectomy ; Turkey - epidemiology</subject><ispartof>The Turkish journal of pediatrics, 2024-05, Vol.66 (2), p.180-190</ispartof><rights>COPYRIGHT 2024 Akdema Informatics and Publishing</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c375t-bc386eaa30b10bac38042d793438ce6d825bdad52cf14689aca5ba07a8e86d33</cites><orcidid>0000-0002-8046-3907 ; 0000-0002-7554-3320 ; 0000-0002-8174-5308 ; 0000-0002-1125-7720 ; 0000-0002-5365-3457 ; 0000-0002-7834-4909 ; 0000-0002-1282-8273 ; 0000-0001-8459-2872 ; 0000-0001-7311-519X ; 0000-0002-6963-9668 ; 0000-0002-2400-6955 ; 0000-0003-0137-0460</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38814299$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yıldırım, Sema</creatorcontrib><creatorcontrib>Haşlak, Fatih</creatorcontrib><creatorcontrib>Yıldız, Mehmet</creatorcontrib><creatorcontrib>Adrovic, Amra</creatorcontrib><creatorcontrib>Aliyeva, Ayten</creatorcontrib><creatorcontrib>Günalp, Aybüke</creatorcontrib><creatorcontrib>Aslan, Esma</creatorcontrib><creatorcontrib>Kılıç Könte, Elif</creatorcontrib><creatorcontrib>Gül, Ümit</creatorcontrib><creatorcontrib>Şahin, Sezgin</creatorcontrib><creatorcontrib>Barut, Kenan</creatorcontrib><creatorcontrib>Kasapçopur, Özgür</creatorcontrib><title>Health conditions of first-degree relatives of children with familial Mediterranean fever</title><title>The Turkish journal of pediatrics</title><addtitle>Turk J Pediatr</addtitle><description>Given the strong genetic background of familial Mediterranean fever (FMF), the frequently reported co-existing diseases in children with FMF should also be investigated in other family members. Therefore, we aimed to examine the medical conditions of first-degree relatives (FDRs) of our pediatric patients with FMF in the present study.
Chronic diseases of FDRs of pediatric 449 FMF, 147 juvenile idiopathic arthritis (JIA) patients and 93 healthy controls (HC) were questioned during their routine clinical visits for 9 consecutive months.
A total of 1975 FDRs of 449 FMF, 690 FDRs of 147 JIA patients, and 406 FDRs of 93 HC were included into the study. The most common medical conditions were non-atopic asthma (n=71, 3.6%), type 2 DM (n=14, 2%), and tonsillectomy history (n=12, 2.95%) in the FMF, JIA, and HC groups, respectively. Atopic diseases (FMF vs. JIA: p=0.013; FMF vs. HC: p=0.014), rheumatic diseases (FMF vs. JIA: p=0.030; FMF vs. HC: p=0.017), and surgical histories (FMF vs. JIA: p<0.01; FMF vs. HC: p=0.026), including adenoidectomy, tonsillectomy, and appendectomy, were significantly more common in the FMF group than in other groups.
Our novel findings may contribute to understanding the hereditary burden of co-existing diseases in children with FMF and encourage further studies involving genetic screenings.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Arthritis</subject><subject>Arthritis, Juvenile - epidemiology</subject><subject>Arthritis, Juvenile - genetics</subject><subject>Asthma - epidemiology</subject><subject>Asthma - genetics</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Chronic diseases</subject><subject>Familial Mediterranean fever</subject><subject>Familial Mediterranean Fever - epidemiology</subject><subject>Familial Mediterranean Fever - genetics</subject><subject>Family</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Genetic screening</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Pediatrics</subject><subject>Tonsillectomy</subject><subject>Turkey - epidemiology</subject><issn>0041-4301</issn><issn>2791-6421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkUtLAzEQx4Motla_gi543prX7iZHEV9Q8eLF0zKbTNrUfZRsVPz2RquiIHMY5vEbZuZPyAmjcy51Ic7ic3hab9B6iGHOKZdzWSi9Q6a80iwvJWe7ZEqpZLkUlE3IwTiuKeUV1dU-mQilmORaT8njDUIbV5kZeuujH_oxG1zmfBhjbnEZELOALUT_gp8Vs_KtDdhnrz5RDjrfemizu7RJxBCgR-gzhy8YDsmeg3bEoy8_Iw9Xlw8XN_ni_vr24nyRG1EVMW-MUCUCCNow2kCKqOS20kIKZbC0iheNBVtw45gslQYDRQO0AoWqtELMyOl27BJarH3vhhjAdH409bmimgnNqU5d83-6klnsfLodnU_5P0C1BUwYxjGgqzfBdxDeakbrTwnq3xLUHxLUHxIk8nhLbp6bDu0P9_1z8Q7f04cU</recordid><startdate>20240523</startdate><enddate>20240523</enddate><creator>Yıldırım, Sema</creator><creator>Haşlak, Fatih</creator><creator>Yıldız, Mehmet</creator><creator>Adrovic, Amra</creator><creator>Aliyeva, Ayten</creator><creator>Günalp, Aybüke</creator><creator>Aslan, Esma</creator><creator>Kılıç Könte, Elif</creator><creator>Gül, Ümit</creator><creator>Şahin, Sezgin</creator><creator>Barut, Kenan</creator><creator>Kasapçopur, Özgür</creator><general>Akdema Informatics and Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-8046-3907</orcidid><orcidid>https://orcid.org/0000-0002-7554-3320</orcidid><orcidid>https://orcid.org/0000-0002-8174-5308</orcidid><orcidid>https://orcid.org/0000-0002-1125-7720</orcidid><orcidid>https://orcid.org/0000-0002-5365-3457</orcidid><orcidid>https://orcid.org/0000-0002-7834-4909</orcidid><orcidid>https://orcid.org/0000-0002-1282-8273</orcidid><orcidid>https://orcid.org/0000-0001-8459-2872</orcidid><orcidid>https://orcid.org/0000-0001-7311-519X</orcidid><orcidid>https://orcid.org/0000-0002-6963-9668</orcidid><orcidid>https://orcid.org/0000-0002-2400-6955</orcidid><orcidid>https://orcid.org/0000-0003-0137-0460</orcidid></search><sort><creationdate>20240523</creationdate><title>Health conditions of first-degree relatives of children with familial Mediterranean fever</title><author>Yıldırım, Sema ; 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Therefore, we aimed to examine the medical conditions of first-degree relatives (FDRs) of our pediatric patients with FMF in the present study.
Chronic diseases of FDRs of pediatric 449 FMF, 147 juvenile idiopathic arthritis (JIA) patients and 93 healthy controls (HC) were questioned during their routine clinical visits for 9 consecutive months.
A total of 1975 FDRs of 449 FMF, 690 FDRs of 147 JIA patients, and 406 FDRs of 93 HC were included into the study. The most common medical conditions were non-atopic asthma (n=71, 3.6%), type 2 DM (n=14, 2%), and tonsillectomy history (n=12, 2.95%) in the FMF, JIA, and HC groups, respectively. Atopic diseases (FMF vs. JIA: p=0.013; FMF vs. HC: p=0.014), rheumatic diseases (FMF vs. JIA: p=0.030; FMF vs. HC: p=0.017), and surgical histories (FMF vs. JIA: p<0.01; FMF vs. HC: p=0.026), including adenoidectomy, tonsillectomy, and appendectomy, were significantly more common in the FMF group than in other groups.
Our novel findings may contribute to understanding the hereditary burden of co-existing diseases in children with FMF and encourage further studies involving genetic screenings.</abstract><cop>Turkey</cop><pub>Akdema Informatics and Publishing</pub><pmid>38814299</pmid><doi>10.24953/turkjpediatr.2024.4589</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-8046-3907</orcidid><orcidid>https://orcid.org/0000-0002-7554-3320</orcidid><orcidid>https://orcid.org/0000-0002-8174-5308</orcidid><orcidid>https://orcid.org/0000-0002-1125-7720</orcidid><orcidid>https://orcid.org/0000-0002-5365-3457</orcidid><orcidid>https://orcid.org/0000-0002-7834-4909</orcidid><orcidid>https://orcid.org/0000-0002-1282-8273</orcidid><orcidid>https://orcid.org/0000-0001-8459-2872</orcidid><orcidid>https://orcid.org/0000-0001-7311-519X</orcidid><orcidid>https://orcid.org/0000-0002-6963-9668</orcidid><orcidid>https://orcid.org/0000-0002-2400-6955</orcidid><orcidid>https://orcid.org/0000-0003-0137-0460</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Arthritis Arthritis, Juvenile - epidemiology Arthritis, Juvenile - genetics Asthma - epidemiology Asthma - genetics Case-Control Studies Child Child, Preschool Children Chronic diseases Familial Mediterranean fever Familial Mediterranean Fever - epidemiology Familial Mediterranean Fever - genetics Family Female Genetic aspects Genetic screening Health aspects Humans Male Medical research Medicine, Experimental Pediatrics Tonsillectomy Turkey - epidemiology |
| title | Health conditions of first-degree relatives of children with familial Mediterranean fever |
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