On the pH-dependence of [alpha]-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation

The aggregation of the protein [alpha]-synuclein is closely associated with several neurodegenerative disorders and as such the structures of the amyloid fibril aggregates have high scientific and medical significance. However, there are dozens of unique atomic-resolution structures of these aggrega...

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Veröffentlicht in:	eLife 2024-08, Vol.12
Hauptverfasser:	Frey, Lukas, Ghosh, Dhiman, Qureshi, Bilal M, Rhyner, David, Guerrero-Ferreira, Ricardo, Pokharna, Aditya, Kwiatkowski, Witek, Serdiuk, Tetiana, Picotti, Paola, Riek, Roland, Greenwald, Jason
Format:	Artikel
Sprache:	eng
Schlagworte:	Genetic aspects Hydrogen-ion concentration Medical research Medicine, Experimental Physiological aspects Seeds
Online-Zugang:	Volltext
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