Determinants of interactions of a novel next-generation gabapentinoid NVA1309 and mirogabalin with the Cav[alpha]2[delta]-1 subunit

NVA1309 is a non-brain penetrant next-generation gabapentinoid shown to bind Cav[alpha]2[delta] at R243 within a triple Arginine motif forming the binding site for gabapentin and pregabalin. In this study we have compared the effects of NVA1309 with Mirogabalin, a gabapentinoid drug with higher affi...

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Veröffentlicht in:	Molecular brain 2024-08, Vol.17 (1)
Hauptverfasser:	Souza, Ivana A, Gandini, Maria A, Ali, Md Yousof, Kricek, Franz, Skouteris, George, Zamponi, Gerald W
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium channels Comparative analysis Gabapentin
Online-Zugang:	Volltext
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