HIF-2[alpha] expression and metabolic signaling require ACSS2 in clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is an aggressive cancer driven by VHL loss and aberrant HIF-2[alpha] signaling. Identifying means to regulate HIF-2[alpha] thus has potential therapeutic benefit. Acetyl- CoA synthetase 2 (ACSS2) converts acetate to acetyl-CoA and is associated with poor patie...

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Veröffentlicht in:	The Journal of clinical investigation 2024-06, Vol.134 (12)
Hauptverfasser:	Bacigalupa, Zachary A, Arner, Emily N, Vlach, Logan M, Wolf, Melissa M, Brown, Whitney A, Krystofiak, Evan S, Ye, Xiang, Hongo, Rachel A, Landis, Madelyn, Amason, Edith K, Beckermann, Kathryn E, Rathmell, W. Kimryn, Rathmell, Jeffrey C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates Cancer Carcinoma, Renal cell Cell metabolism Cellular signal transduction Development and progression Gene expression Genetic aspects Health aspects Ligases Oncology, Experimental Physiological aspects Prognosis Proteolysis Transcription factors
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