Unmasking the Mechanism behind Miltefosine: Revealing the Disruption of Intracellular Ca[sup.2+] Homeostasis as a Rational Therapeutic Target in Leishmaniasis and Chagas Disease

Originally developed as a chemotherapeutic agent, miltefosine (hexadecylphosphocholine) is an inhibitor of phosphatidylcholine synthesis with proven antiparasitic effects. It is the only oral drug approved for the treatment of Leishmaniasis and American Trypanosomiasis (Chagas disease). Although its...

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Veröffentlicht in:	Biomolecules (Basel, Switzerland) Switzerland), 2024-04, Vol.14 (4)
Hauptverfasser:	Benaim, Gustavo, Paniz-Mondolfi, Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium ions Chagas' disease Drug targeting Drug therapy Health aspects Homeostasis Leishmaniasis Methods
Online-Zugang:	Volltext
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