In Vitro Low-Bortezomib Doses Induce Apoptosis and Independently Decrease the Activities of Glutathione S-Transferase and Glutathione Peroxidase in Multiple Myeloma, Taking into Account the IGSTT1/I and IGSTM1/I Gene Variants

Background: Multiple myeloma (MM) is a malignancy derived from plasma cells. Bortezomib affects the concentration of reduced glutathione (GSH) and the activity of glutathione enzymes. The aim of our study was to analyze deletion (null/present) variants of GSTT1 and GSTM1 genes and their association...

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Veröffentlicht in:	Genes 2024-03, Vol.15 (3)
Hauptverfasser:	Zmorzynski, Szymon, Popek-Marciniec, Sylwia, Biernacka, Beata, Szudy-Szczyrek, Aneta, Chocholska, Sylwia, Styk, Wojciech, Czerwik-Marcinkowska, Joanna, Swiderska-Kolacz, Grazyna
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Apoptosis Blood donors Bortezomib Fluorescence microscopy Genes Glutathione transferase Peroxidase Thiols
Online-Zugang:	Volltext
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