Unveiling Novel Urease Inhibitors for IHelicobacter pylori/I: A Multi-Methodological Approach from Virtual Screening and ADME to Molecular Dynamics Simulations

Helicobacter pylori (Hp) infections pose a global health challenge demanding innovative therapeutic strategies by which to eradicate them. Urease, a key Hp virulence factor hydrolyzes urea, facilitating bacterial survival in the acidic gastric environment. In this study, a multi-methodological appro...

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Veröffentlicht in:	International journal of molecular sciences 2024-02, Vol.25 (4)
Hauptverfasser:	Valenzuela-Hormazabal, Paulina, Sepúlveda, Romina V, Alegría-Arcos, Melissa, Valdés-Muñoz, Elizabeth, Rojas-Pérez, Víctor, González-Bonet, Ileana, Suardíaz, Reynier, Galarza, Christian, Morales, Natalia, Leddermann, Verónica, Castro, Ricardo I, Benso, Bruna, Urra, Gabriela, Hernández-Rodríguez, Erix W, Bustos, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Enzymes Health aspects Helicobacter pylori Hydrolases Metronidazole Molecular dynamics Simulation methods Urea Virulence (Microbiology)
Online-Zugang:	Volltext
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