Association Between Nonthyroidal Illness Syndrome and Disseminated Intravascular Coagulation in Sepsis
Purpose: Both nonthyroidal illness syndrome (NTIS) and disseminated intravascular coagulation (DIC) are commonly occurred in sepsis. The objective of this study is to evaluate the association between NTIS and DIC, as well as their impacts on the mortality in adults with sepsis. Patients and methods:...
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| Veröffentlicht in: | Journal of inflammation research 2024-01, Vol.16, p.497 |
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| creator | Yao, Yi Li, Juan Sun, Wenwu Ma, Chaoping Ning, Ning Li, Jiaoyan Ni, Tongtian Gui, Menglu Chen, Ying Zhao, Bing Zhang, Jiyuan Zhu, Jiyue Gao, Chengjin Sheng, Huiqiu Mao, Enqiang |
| description | Purpose: Both nonthyroidal illness syndrome (NTIS) and disseminated intravascular coagulation (DIC) are commonly occurred in sepsis. The objective of this study is to evaluate the association between NTIS and DIC, as well as their impacts on the mortality in adults with sepsis. Patients and methods: A total of 1219 septic patients in two Chinese academic centers from October 2012 and October 2022 were enrolled in analysis. We conduct logistic regression models to analyze the independent risk factors for DIC. Modified Poisson regression models are used to estimate the relative risk (RR) of NTIS on the 28 days mortality in septic patients with DIC. Correlation analysis between thyroid function parameters and coagulation parameters is performed with Pearson coefficient be reported. Results: DIC is diagnosed on 388 (31.8%) of all the 1219 enrolled septic patients within 72 hours after admission. In multivariate logistic regression models, NTIS (OR 3.19; CI 2.31-4.46; p |
| doi_str_mv | 10.2147/JIR.S447181 |
| format | Article |
| fullrecord | <record><control><sourceid>gale</sourceid><recordid>TN_cdi_gale_infotracmisc_A783300315</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A783300315</galeid><sourcerecordid>A783300315</sourcerecordid><originalsourceid>FETCH-LOGICAL-g985-dc9c91e95fbf0fcb8a54b0cd87c2b2fdd169388996236389c1e72f490127206a3</originalsourceid><addsrcrecordid>eNptUE1LAzEQDaJgqT35BwKCt61J9iPJsVarK0XB9l6y-WgjaSI7W6X_3q16qODMYR7De495g9AlJWNGC37zVL-OF0XBqaAnaEApFxknOT09wudoBPBGDsVJwYoBchOApL3qfIr41naf1kb8nGK32bfJGxVwHUK0AHixj6ZNW4tVNPjOA9itj6qzBtexa9WHAr0LqsXTpNY9-Db0ES_sO3i4QGdOBbCj3zlEy9n9cvqYzV8e6ulknq2lKDOjpZbUytI1jjjdCFUWDdFGcM0a5oyhlcyFkLJieZULqanlzBWSUMYZqVQ-RFc_tmsV7MpHl_rL9NaDXk24yHPS_6DsWeN_WH2bPpJO0Trf7_8Iro8EG6tCt4EUdoeMcEz8AryEdao</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Association Between Nonthyroidal Illness Syndrome and Disseminated Intravascular Coagulation in Sepsis</title><source>Taylor & Francis Open Access</source><source>DOVE Medical Press Journals</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Yao, Yi ; Li, Juan ; Sun, Wenwu ; Ma, Chaoping ; Ning, Ning ; Li, Jiaoyan ; Ni, Tongtian ; Gui, Menglu ; Chen, Ying ; Zhao, Bing ; Zhang, Jiyuan ; Zhu, Jiyue ; Gao, Chengjin ; Sheng, Huiqiu ; Mao, Enqiang</creator><creatorcontrib>Yao, Yi ; Li, Juan ; Sun, Wenwu ; Ma, Chaoping ; Ning, Ning ; Li, Jiaoyan ; Ni, Tongtian ; Gui, Menglu ; Chen, Ying ; Zhao, Bing ; Zhang, Jiyuan ; Zhu, Jiyue ; Gao, Chengjin ; Sheng, Huiqiu ; Mao, Enqiang</creatorcontrib><description>Purpose: Both nonthyroidal illness syndrome (NTIS) and disseminated intravascular coagulation (DIC) are commonly occurred in sepsis. The objective of this study is to evaluate the association between NTIS and DIC, as well as their impacts on the mortality in adults with sepsis. Patients and methods: A total of 1219 septic patients in two Chinese academic centers from October 2012 and October 2022 were enrolled in analysis. We conduct logistic regression models to analyze the independent risk factors for DIC. Modified Poisson regression models are used to estimate the relative risk (RR) of NTIS on the 28 days mortality in septic patients with DIC. Correlation analysis between thyroid function parameters and coagulation parameters is performed with Pearson coefficient be reported. Results: DIC is diagnosed on 388 (31.8%) of all the 1219 enrolled septic patients within 72 hours after admission. In multivariate logistic regression models, NTIS (OR 3.19; CI 2.31-4.46; p<0.001) is a statistically significant independent risk factor for DIC after adjustment for potential confounders. Twenty-eight days mortality is significantly higher in DIC patients complicated with NTIS compared with the other DIC patients (23.2% vs 14.0%, p=0.024). This result is also robust in different modified Poisson regression models (Model 1: RR 1.46; CI 1.25-1.70; p<0.001; Model 2: RR 1.35; CI 1.14-1.60; p<0.001; Model 3: RR 1.18; CI 1.02-1.37; p=0.026). Correlation analysis reveals that the thyroid function parameters of FT3, FT4 and TSH only have weak correlations with coagulation parameters of platelet count, fibrinogen, FDP, D-dimers, PT, APTT and INR in sepsis. Conclusion: NTIS is an independent risk factor for DIC in adults with sepsis. DIC patients complicated with NTIS have significantly higher severity and higher rate of mortality. Keywords: sepsis, low T3 syndrome, nonthyroidal illness syndrome, thyroid function, disseminated intravascular coagulation</description><identifier>ISSN: 1178-7031</identifier><identifier>EISSN: 1178-7031</identifier><identifier>DOI: 10.2147/JIR.S447181</identifier><language>eng</language><publisher>Dove Medical Press Limited</publisher><subject>Analysis ; Disseminated intravascular coagulation ; Fibrin ; Health aspects ; Infection ; Risk factors ; Thyroid gland</subject><ispartof>Journal of inflammation research, 2024-01, Vol.16, p.497</ispartof><rights>COPYRIGHT 2024 Dove Medical Press Limited</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids></links><search><creatorcontrib>Yao, Yi</creatorcontrib><creatorcontrib>Li, Juan</creatorcontrib><creatorcontrib>Sun, Wenwu</creatorcontrib><creatorcontrib>Ma, Chaoping</creatorcontrib><creatorcontrib>Ning, Ning</creatorcontrib><creatorcontrib>Li, Jiaoyan</creatorcontrib><creatorcontrib>Ni, Tongtian</creatorcontrib><creatorcontrib>Gui, Menglu</creatorcontrib><creatorcontrib>Chen, Ying</creatorcontrib><creatorcontrib>Zhao, Bing</creatorcontrib><creatorcontrib>Zhang, Jiyuan</creatorcontrib><creatorcontrib>Zhu, Jiyue</creatorcontrib><creatorcontrib>Gao, Chengjin</creatorcontrib><creatorcontrib>Sheng, Huiqiu</creatorcontrib><creatorcontrib>Mao, Enqiang</creatorcontrib><title>Association Between Nonthyroidal Illness Syndrome and Disseminated Intravascular Coagulation in Sepsis</title><title>Journal of inflammation research</title><description>Purpose: Both nonthyroidal illness syndrome (NTIS) and disseminated intravascular coagulation (DIC) are commonly occurred in sepsis. The objective of this study is to evaluate the association between NTIS and DIC, as well as their impacts on the mortality in adults with sepsis. Patients and methods: A total of 1219 septic patients in two Chinese academic centers from October 2012 and October 2022 were enrolled in analysis. We conduct logistic regression models to analyze the independent risk factors for DIC. Modified Poisson regression models are used to estimate the relative risk (RR) of NTIS on the 28 days mortality in septic patients with DIC. Correlation analysis between thyroid function parameters and coagulation parameters is performed with Pearson coefficient be reported. Results: DIC is diagnosed on 388 (31.8%) of all the 1219 enrolled septic patients within 72 hours after admission. In multivariate logistic regression models, NTIS (OR 3.19; CI 2.31-4.46; p<0.001) is a statistically significant independent risk factor for DIC after adjustment for potential confounders. Twenty-eight days mortality is significantly higher in DIC patients complicated with NTIS compared with the other DIC patients (23.2% vs 14.0%, p=0.024). This result is also robust in different modified Poisson regression models (Model 1: RR 1.46; CI 1.25-1.70; p<0.001; Model 2: RR 1.35; CI 1.14-1.60; p<0.001; Model 3: RR 1.18; CI 1.02-1.37; p=0.026). Correlation analysis reveals that the thyroid function parameters of FT3, FT4 and TSH only have weak correlations with coagulation parameters of platelet count, fibrinogen, FDP, D-dimers, PT, APTT and INR in sepsis. Conclusion: NTIS is an independent risk factor for DIC in adults with sepsis. DIC patients complicated with NTIS have significantly higher severity and higher rate of mortality. Keywords: sepsis, low T3 syndrome, nonthyroidal illness syndrome, thyroid function, disseminated intravascular coagulation</description><subject>Analysis</subject><subject>Disseminated intravascular coagulation</subject><subject>Fibrin</subject><subject>Health aspects</subject><subject>Infection</subject><subject>Risk factors</subject><subject>Thyroid gland</subject><issn>1178-7031</issn><issn>1178-7031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptUE1LAzEQDaJgqT35BwKCt61J9iPJsVarK0XB9l6y-WgjaSI7W6X_3q16qODMYR7De495g9AlJWNGC37zVL-OF0XBqaAnaEApFxknOT09wudoBPBGDsVJwYoBchOApL3qfIr41naf1kb8nGK32bfJGxVwHUK0AHixj6ZNW4tVNPjOA9itj6qzBtexa9WHAr0LqsXTpNY9-Db0ES_sO3i4QGdOBbCj3zlEy9n9cvqYzV8e6ulknq2lKDOjpZbUytI1jjjdCFUWDdFGcM0a5oyhlcyFkLJieZULqanlzBWSUMYZqVQ-RFc_tmsV7MpHl_rL9NaDXk24yHPS_6DsWeN_WH2bPpJO0Trf7_8Iro8EG6tCt4EUdoeMcEz8AryEdao</recordid><startdate>20240131</startdate><enddate>20240131</enddate><creator>Yao, Yi</creator><creator>Li, Juan</creator><creator>Sun, Wenwu</creator><creator>Ma, Chaoping</creator><creator>Ning, Ning</creator><creator>Li, Jiaoyan</creator><creator>Ni, Tongtian</creator><creator>Gui, Menglu</creator><creator>Chen, Ying</creator><creator>Zhao, Bing</creator><creator>Zhang, Jiyuan</creator><creator>Zhu, Jiyue</creator><creator>Gao, Chengjin</creator><creator>Sheng, Huiqiu</creator><creator>Mao, Enqiang</creator><general>Dove Medical Press Limited</general><scope/></search><sort><creationdate>20240131</creationdate><title>Association Between Nonthyroidal Illness Syndrome and Disseminated Intravascular Coagulation in Sepsis</title><author>Yao, Yi ; Li, Juan ; Sun, Wenwu ; Ma, Chaoping ; Ning, Ning ; Li, Jiaoyan ; Ni, Tongtian ; Gui, Menglu ; Chen, Ying ; Zhao, Bing ; Zhang, Jiyuan ; Zhu, Jiyue ; Gao, Chengjin ; Sheng, Huiqiu ; Mao, Enqiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g985-dc9c91e95fbf0fcb8a54b0cd87c2b2fdd169388996236389c1e72f490127206a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Analysis</topic><topic>Disseminated intravascular coagulation</topic><topic>Fibrin</topic><topic>Health aspects</topic><topic>Infection</topic><topic>Risk factors</topic><topic>Thyroid gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yao, Yi</creatorcontrib><creatorcontrib>Li, Juan</creatorcontrib><creatorcontrib>Sun, Wenwu</creatorcontrib><creatorcontrib>Ma, Chaoping</creatorcontrib><creatorcontrib>Ning, Ning</creatorcontrib><creatorcontrib>Li, Jiaoyan</creatorcontrib><creatorcontrib>Ni, Tongtian</creatorcontrib><creatorcontrib>Gui, Menglu</creatorcontrib><creatorcontrib>Chen, Ying</creatorcontrib><creatorcontrib>Zhao, Bing</creatorcontrib><creatorcontrib>Zhang, Jiyuan</creatorcontrib><creatorcontrib>Zhu, Jiyue</creatorcontrib><creatorcontrib>Gao, Chengjin</creatorcontrib><creatorcontrib>Sheng, Huiqiu</creatorcontrib><creatorcontrib>Mao, Enqiang</creatorcontrib><jtitle>Journal of inflammation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yao, Yi</au><au>Li, Juan</au><au>Sun, Wenwu</au><au>Ma, Chaoping</au><au>Ning, Ning</au><au>Li, Jiaoyan</au><au>Ni, Tongtian</au><au>Gui, Menglu</au><au>Chen, Ying</au><au>Zhao, Bing</au><au>Zhang, Jiyuan</au><au>Zhu, Jiyue</au><au>Gao, Chengjin</au><au>Sheng, Huiqiu</au><au>Mao, Enqiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Between Nonthyroidal Illness Syndrome and Disseminated Intravascular Coagulation in Sepsis</atitle><jtitle>Journal of inflammation research</jtitle><date>2024-01-31</date><risdate>2024</risdate><volume>16</volume><spage>497</spage><pages>497-</pages><issn>1178-7031</issn><eissn>1178-7031</eissn><abstract>Purpose: Both nonthyroidal illness syndrome (NTIS) and disseminated intravascular coagulation (DIC) are commonly occurred in sepsis. The objective of this study is to evaluate the association between NTIS and DIC, as well as their impacts on the mortality in adults with sepsis. Patients and methods: A total of 1219 septic patients in two Chinese academic centers from October 2012 and October 2022 were enrolled in analysis. We conduct logistic regression models to analyze the independent risk factors for DIC. Modified Poisson regression models are used to estimate the relative risk (RR) of NTIS on the 28 days mortality in septic patients with DIC. Correlation analysis between thyroid function parameters and coagulation parameters is performed with Pearson coefficient be reported. Results: DIC is diagnosed on 388 (31.8%) of all the 1219 enrolled septic patients within 72 hours after admission. In multivariate logistic regression models, NTIS (OR 3.19; CI 2.31-4.46; p<0.001) is a statistically significant independent risk factor for DIC after adjustment for potential confounders. Twenty-eight days mortality is significantly higher in DIC patients complicated with NTIS compared with the other DIC patients (23.2% vs 14.0%, p=0.024). This result is also robust in different modified Poisson regression models (Model 1: RR 1.46; CI 1.25-1.70; p<0.001; Model 2: RR 1.35; CI 1.14-1.60; p<0.001; Model 3: RR 1.18; CI 1.02-1.37; p=0.026). Correlation analysis reveals that the thyroid function parameters of FT3, FT4 and TSH only have weak correlations with coagulation parameters of platelet count, fibrinogen, FDP, D-dimers, PT, APTT and INR in sepsis. Conclusion: NTIS is an independent risk factor for DIC in adults with sepsis. DIC patients complicated with NTIS have significantly higher severity and higher rate of mortality. Keywords: sepsis, low T3 syndrome, nonthyroidal illness syndrome, thyroid function, disseminated intravascular coagulation</abstract><pub>Dove Medical Press Limited</pub><doi>10.2147/JIR.S447181</doi></addata></record> |
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| subjects | Analysis Disseminated intravascular coagulation Fibrin Health aspects Infection Risk factors Thyroid gland |
| title | Association Between Nonthyroidal Illness Syndrome and Disseminated Intravascular Coagulation in Sepsis |
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