Strong inhibition of TNF-[alpha] production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase inhibitor

In inflammatory processes, the p38 mitogen-activated protein kinase (MAPK) signal transduction route regulates production and expression of cytokines and other inflammatory mediators. Tumor necrosis factor [alpha] (TNF-[alpha]) is a pivotal cytokine in rheumatoid arthritis and its production in macr...

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Veröffentlicht in:	Arthritis research & therapy 2004-06, Vol.6 (4)
Hauptverfasser:	Westra, Johanna, Doornbos-van der Meer, Berber, de Boer, Peter, van Leeuwen, Miek A, van Rijswijk, Ma, Limburg, Pieter C
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Care and treatment Diagnosis Macrophages Messenger RNA Rheumatoid arthritis Tumor necrosis factor
Online-Zugang:	Volltext
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