Impaired T cell IRE1[alpha]/XBP1 signaling directs inflammation in experimental heart failure with preserved ejection fraction

Heart failure with preserved ejection fraction (HFpEF) is a widespread syndrome with limited therapeutic options and poorly understood immune pathophysiology. Using a 2-hit preclinical model of cardiometabolic HFpEF that induces obesity and hypertension, we found that cardiac T cell infiltration and...

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Veröffentlicht in:	The Journal of clinical investigation 2023-12, Vol.133 (24)
Hauptverfasser:	Smolgovsky, Sasha, Bayer, Abraham L, Kaur, Kuljeet, Sanders, Erin, Aronovitz, Mark, Filipp, Mallory E, Thorp, Edward B, Schiattarella, Gabriele G, Hill, Joseph A, Blanton, Robert M, Cubillos-Ruiz, Juan R, Alcaide, Pilar
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antigens Cardiac output Health aspects Heart failure Measurement Physiology, Pathological Prevention Risk factors Testing
Online-Zugang:	Volltext
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