Rational design of a SOCSI-edited tumor-infiltrating lymphocyte therapy using CRISPR/Cas9 screens

Cell therapies such as tumor-infiltrating lymphocyte (TIL) therapy have shown promise in the treatment of patients with refractory solid tumors, with improvement in response rates and durability of responses nevertheless sought. To identify targets capable of enhancing the antitumor activity of T ce...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of clinical investigation 2023-12, Vol.133 (24)
Hauptverfasser:	Schlabach, Michael R, Lin, Sharon, Collester, Zachary R, Wrocklage, Christopher, Shenker, Sol, Calnan, Conor, Xu, Tianlei, Gannon, Hugh S, Williams, Leila J, Thompson, Frank, Dunbar, Paul R, LaMothe, Robert A, Garrett, Tracy E, Colletti, Nicholas, Hohmann, Anja F, Tubo, Noah J, Bullock, Caroline P, Mercier, Isabelle Le, Sofjan, Katri, Merkin, Jason J, Keegan, Sean, Kryukov, Gregory V, Dugopolski, Caroline, Stegmeier, Frank, Wong, Karrie, Sharp, Fiona A, Cadzow, Louise, Benson, Micah J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis B cells Cancer Care and treatment Genes Genetic aspects Immunotherapy Methods T cells Tumor-infiltrating lymphocytes Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!