Structural Studies of IKlebsiella pneumoniae/I Fosfomycin-Resistance Protein and Its Application for the Development of an Optical Biosensor for Fosfomycin Determination

Fosfomycin-resistance proteins (FosAs) are dimeric metal-dependent glutathione transferases that conjugate the antibiotic fosfomycin (Fos) to the tripeptide glutathione (γ-Glu-Cys-Gly, GSH), rendering it inactive. In the present study, we reported a comparative analysis of the functional features of...

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Veröffentlicht in:	International journal of molecular sciences 2023-12, Vol.25 (1)
Hauptverfasser:	Varotsou, Christina, Ataya, Farid, Papageorgiou, Anastassios C, Labrou, Nikolaos E
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial pneumonia Comparative analysis Crosslinked polymers Crystals Detectors Drug resistance in microorganisms Escherichia coli Fosfomycin Genetic engineering Pneumonia Structure Transferases
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