Vernonia amygdalina protects against doxorubicin-induced hepatic and renal damage in rats: mechanistic insights
The use of the chemotherapeutic agent doxorubicin is limited due to its potential to cause signifi-cant hepatorenal damage. The present study aimed to investigate the potential hepatoprotective and nephroprotective effects of Vernonia amygdalina , a medicinal plant with known antioxidant and anti-in...
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| Veröffentlicht in: | Farmacija 2023-09, Vol.70 (3), p.825-835 |
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| creator | Prananda, Arya Tjipta Dalimunthe, Aminah Harahap, Urip Abdi Syahputra, Rony Nugraha, Sony Eka Situmorang, Putri Cahaya Fah, Yee Teck Velaro, Adrian Joshua Bilakaya, Besa Harahap, Muhammad Andika Yudha |
| description | The use of the chemotherapeutic agent doxorubicin is limited due to its potential to cause signifi-cant hepatorenal damage. The present study aimed to investigate the potential hepatoprotective and nephroprotective effects of
Vernonia amygdalina
, a medicinal plant with known antioxidant and anti-inflammatory properties, against doxorubicin-induced toxicity in rats. Male Wistar rats were randomly divided into four groups: Control, Doxorubicin (DOX), DOX + Vernonia Amyg-dalina (DOX+VA), and
Vernonia amygdalina
(VA) alone. DOX and DOX+VA groups were treated with a single intraperitoneal injection of doxorubicin (15 mg/kg body weight). The DOX+VA group received
Vernonia amygdalina
extract (100, 300, 500 mg/kg body weight) by oral gavage for 14 days following doxorubicin injection. The results demonstrated that
Vernonia amygdalina
significantly reduced the elevated levels of liver and kidney function biomarkers, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and creatinine, induced by doxorubicin. The histological examination of the liver and kidney tis-sues also confirmed the protective effects of
Vernonia amygdalina
against doxorubicin-induced damage. Furthermore,
Vernonia amygdalina
treatment was found to mitigate oxidative stress by restoring the levels of glutathione (GPx), Catalase, NO and SOD and decreasing the level of malondialdehyde (MDA) in liver and kidney tissues. Additionally,
Vernonia amygdalina
sig-nificantly suppressed the renal injury markers, NGAL, cystatin-c, KIM-1, and NAG. In conclu-sion, the results of this study suggest that
Vernonia amygdalina
has potent hepatoprotective and nephroprotective effects against doxorubicin-induced toxicity in rats. These protective effects are mediated by its antioxidant, and free radical scavenging properties. Further investigation is needed to determine the potential clinical relevance of
Vernonia amygdalina
in protecting against the hepatorenal damage induced by doxorubicin in human subjects.
Graphical abstract
: |
| doi_str_mv | 10.3897/pharmacia.70.e112425 |
| format | Article |
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Vernonia amygdalina
, a medicinal plant with known antioxidant and anti-inflammatory properties, against doxorubicin-induced toxicity in rats. Male Wistar rats were randomly divided into four groups: Control, Doxorubicin (DOX), DOX + Vernonia Amyg-dalina (DOX+VA), and
Vernonia amygdalina
(VA) alone. DOX and DOX+VA groups were treated with a single intraperitoneal injection of doxorubicin (15 mg/kg body weight). The DOX+VA group received
Vernonia amygdalina
extract (100, 300, 500 mg/kg body weight) by oral gavage for 14 days following doxorubicin injection. The results demonstrated that
Vernonia amygdalina
significantly reduced the elevated levels of liver and kidney function biomarkers, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and creatinine, induced by doxorubicin. The histological examination of the liver and kidney tis-sues also confirmed the protective effects of
Vernonia amygdalina
against doxorubicin-induced damage. Furthermore,
Vernonia amygdalina
treatment was found to mitigate oxidative stress by restoring the levels of glutathione (GPx), Catalase, NO and SOD and decreasing the level of malondialdehyde (MDA) in liver and kidney tissues. Additionally,
Vernonia amygdalina
sig-nificantly suppressed the renal injury markers, NGAL, cystatin-c, KIM-1, and NAG. In conclu-sion, the results of this study suggest that
Vernonia amygdalina
has potent hepatoprotective and nephroprotective effects against doxorubicin-induced toxicity in rats. These protective effects are mediated by its antioxidant, and free radical scavenging properties. Further investigation is needed to determine the potential clinical relevance of
Vernonia amygdalina
in protecting against the hepatorenal damage induced by doxorubicin in human subjects.
Graphical abstract
:</description><identifier>ISSN: 0428-0296</identifier><identifier>EISSN: 2603-557X</identifier><identifier>DOI: 10.3897/pharmacia.70.e112425</identifier><language>eng</language><publisher>Pensoft Publishers</publisher><subject>Anthracyclines ; Cancer ; Care and treatment</subject><ispartof>Farmacija, 2023-09, Vol.70 (3), p.825-835</ispartof><rights>COPYRIGHT 2023 Pensoft Publishers</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-cfb1d7292f61bdb107792612b6438baf7b1c5325fcf6226d75f5cbd1f58fc7233</citedby><cites>FETCH-LOGICAL-c430t-cfb1d7292f61bdb107792612b6438baf7b1c5325fcf6226d75f5cbd1f58fc7233</cites><orcidid>0000-0003-0566-2065 ; 0000-0002-9895-1853 ; 0000-0003-2016-0151</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids></links><search><creatorcontrib>Prananda, Arya Tjipta</creatorcontrib><creatorcontrib>Dalimunthe, Aminah</creatorcontrib><creatorcontrib>Harahap, Urip</creatorcontrib><creatorcontrib>Abdi Syahputra, Rony</creatorcontrib><creatorcontrib>Nugraha, Sony Eka</creatorcontrib><creatorcontrib>Situmorang, Putri Cahaya</creatorcontrib><creatorcontrib>Fah, Yee Teck</creatorcontrib><creatorcontrib>Velaro, Adrian Joshua</creatorcontrib><creatorcontrib>Bilakaya, Besa</creatorcontrib><creatorcontrib>Harahap, Muhammad Andika Yudha</creatorcontrib><title>Vernonia amygdalina protects against doxorubicin-induced hepatic and renal damage in rats: mechanistic insights</title><title>Farmacija</title><description>The use of the chemotherapeutic agent doxorubicin is limited due to its potential to cause signifi-cant hepatorenal damage. The present study aimed to investigate the potential hepatoprotective and nephroprotective effects of
Vernonia amygdalina
, a medicinal plant with known antioxidant and anti-inflammatory properties, against doxorubicin-induced toxicity in rats. Male Wistar rats were randomly divided into four groups: Control, Doxorubicin (DOX), DOX + Vernonia Amyg-dalina (DOX+VA), and
Vernonia amygdalina
(VA) alone. DOX and DOX+VA groups were treated with a single intraperitoneal injection of doxorubicin (15 mg/kg body weight). The DOX+VA group received
Vernonia amygdalina
extract (100, 300, 500 mg/kg body weight) by oral gavage for 14 days following doxorubicin injection. The results demonstrated that
Vernonia amygdalina
significantly reduced the elevated levels of liver and kidney function biomarkers, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and creatinine, induced by doxorubicin. The histological examination of the liver and kidney tis-sues also confirmed the protective effects of
Vernonia amygdalina
against doxorubicin-induced damage. Furthermore,
Vernonia amygdalina
treatment was found to mitigate oxidative stress by restoring the levels of glutathione (GPx), Catalase, NO and SOD and decreasing the level of malondialdehyde (MDA) in liver and kidney tissues. Additionally,
Vernonia amygdalina
sig-nificantly suppressed the renal injury markers, NGAL, cystatin-c, KIM-1, and NAG. In conclu-sion, the results of this study suggest that
Vernonia amygdalina
has potent hepatoprotective and nephroprotective effects against doxorubicin-induced toxicity in rats. These protective effects are mediated by its antioxidant, and free radical scavenging properties. Further investigation is needed to determine the potential clinical relevance of
Vernonia amygdalina
in protecting against the hepatorenal damage induced by doxorubicin in human subjects.
Graphical abstract
:</description><subject>Anthracyclines</subject><subject>Cancer</subject><subject>Care and treatment</subject><issn>0428-0296</issn><issn>2603-557X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNptkUFr3DAQhUVJoUuSf9CDoGdvpLEt2bmFkLYLgV7S0psYjSSvwlpaJAeaf18nGwKFMoeB4XtvHjzGPkuxbYdRXx33WGakiFsttl5K6KD_wDagRNv0vf59xjaig6ERMKpP7LLWRyEEDGIYYdiw_MuXlFNEjvPz5PAQE_JjyYunpXKcMKa6cJf_5PJkI8XUxOSeyDu-90dcInFMjhef8MAdzjh5HhMvuNRrPnvaY4r1hVpt4rRf6gX7GPBQ_eXbPmc_v9493H5v7n98293e3DfUtWJpKFjpNIwQlLTOSqH1CEqCVV07WAzaSupb6AMFBaCc7kNP1snQD4E0tO052518XcZHcyxxxvJsMkbzeshlMljWYAdv1i8gXSdU0F0HTlmHloS03mlCK9Tq9eXkNeGKxxTyUpDmWMncaK3GUYEWK7X9D7WO83OknHyI6_0fQXcSUMm1Fh_eY0phXqo179UaLcxbte1fM16bTQ</recordid><startdate>20230919</startdate><enddate>20230919</enddate><creator>Prananda, Arya Tjipta</creator><creator>Dalimunthe, Aminah</creator><creator>Harahap, Urip</creator><creator>Abdi Syahputra, Rony</creator><creator>Nugraha, Sony Eka</creator><creator>Situmorang, Putri Cahaya</creator><creator>Fah, Yee Teck</creator><creator>Velaro, Adrian Joshua</creator><creator>Bilakaya, Besa</creator><creator>Harahap, Muhammad Andika Yudha</creator><general>Pensoft Publishers</general><scope>AAYXX</scope><scope>CITATION</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-0566-2065</orcidid><orcidid>https://orcid.org/0000-0002-9895-1853</orcidid><orcidid>https://orcid.org/0000-0003-2016-0151</orcidid></search><sort><creationdate>20230919</creationdate><title>Vernonia amygdalina protects against doxorubicin-induced hepatic and renal damage in rats: mechanistic insights</title><author>Prananda, Arya Tjipta ; Dalimunthe, Aminah ; Harahap, Urip ; Abdi Syahputra, Rony ; Nugraha, Sony Eka ; Situmorang, Putri Cahaya ; Fah, Yee Teck ; Velaro, Adrian Joshua ; Bilakaya, Besa ; Harahap, Muhammad Andika Yudha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-cfb1d7292f61bdb107792612b6438baf7b1c5325fcf6226d75f5cbd1f58fc7233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Anthracyclines</topic><topic>Cancer</topic><topic>Care and treatment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prananda, Arya Tjipta</creatorcontrib><creatorcontrib>Dalimunthe, Aminah</creatorcontrib><creatorcontrib>Harahap, Urip</creatorcontrib><creatorcontrib>Abdi Syahputra, Rony</creatorcontrib><creatorcontrib>Nugraha, Sony Eka</creatorcontrib><creatorcontrib>Situmorang, Putri Cahaya</creatorcontrib><creatorcontrib>Fah, Yee Teck</creatorcontrib><creatorcontrib>Velaro, Adrian Joshua</creatorcontrib><creatorcontrib>Bilakaya, Besa</creatorcontrib><creatorcontrib>Harahap, Muhammad Andika Yudha</creatorcontrib><collection>CrossRef</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Farmacija</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prananda, Arya Tjipta</au><au>Dalimunthe, Aminah</au><au>Harahap, Urip</au><au>Abdi Syahputra, Rony</au><au>Nugraha, Sony Eka</au><au>Situmorang, Putri Cahaya</au><au>Fah, Yee Teck</au><au>Velaro, Adrian Joshua</au><au>Bilakaya, Besa</au><au>Harahap, Muhammad Andika Yudha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vernonia amygdalina protects against doxorubicin-induced hepatic and renal damage in rats: mechanistic insights</atitle><jtitle>Farmacija</jtitle><date>2023-09-19</date><risdate>2023</risdate><volume>70</volume><issue>3</issue><spage>825</spage><epage>835</epage><pages>825-835</pages><issn>0428-0296</issn><eissn>2603-557X</eissn><abstract>The use of the chemotherapeutic agent doxorubicin is limited due to its potential to cause signifi-cant hepatorenal damage. The present study aimed to investigate the potential hepatoprotective and nephroprotective effects of
Vernonia amygdalina
, a medicinal plant with known antioxidant and anti-inflammatory properties, against doxorubicin-induced toxicity in rats. Male Wistar rats were randomly divided into four groups: Control, Doxorubicin (DOX), DOX + Vernonia Amyg-dalina (DOX+VA), and
Vernonia amygdalina
(VA) alone. DOX and DOX+VA groups were treated with a single intraperitoneal injection of doxorubicin (15 mg/kg body weight). The DOX+VA group received
Vernonia amygdalina
extract (100, 300, 500 mg/kg body weight) by oral gavage for 14 days following doxorubicin injection. The results demonstrated that
Vernonia amygdalina
significantly reduced the elevated levels of liver and kidney function biomarkers, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and creatinine, induced by doxorubicin. The histological examination of the liver and kidney tis-sues also confirmed the protective effects of
Vernonia amygdalina
against doxorubicin-induced damage. Furthermore,
Vernonia amygdalina
treatment was found to mitigate oxidative stress by restoring the levels of glutathione (GPx), Catalase, NO and SOD and decreasing the level of malondialdehyde (MDA) in liver and kidney tissues. Additionally,
Vernonia amygdalina
sig-nificantly suppressed the renal injury markers, NGAL, cystatin-c, KIM-1, and NAG. In conclu-sion, the results of this study suggest that
Vernonia amygdalina
has potent hepatoprotective and nephroprotective effects against doxorubicin-induced toxicity in rats. These protective effects are mediated by its antioxidant, and free radical scavenging properties. Further investigation is needed to determine the potential clinical relevance of
Vernonia amygdalina
in protecting against the hepatorenal damage induced by doxorubicin in human subjects.
Graphical abstract
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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Anthracyclines Cancer Care and treatment |
| title | Vernonia amygdalina protects against doxorubicin-induced hepatic and renal damage in rats: mechanistic insights |
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