Cucurbitacin E reduces IL-1[beta]-induced inflammation and cartilage degeneration by inhibiting the PI3K/Akt pathway in osteoarthritic chondrocytes

Background Osteoarthritis is a degenerative joint disease. Cartilage degeneration is the earliest and most important pathological change in osteoarthritis, and persistent inflammation is one of the driving factors of cartilage degeneration. Cucurbitacin E, an isolated compound in the Cucurbitacin fa...

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Veröffentlicht in:	Journal of translational medicine 2023-12, Vol.21 (1)
Hauptverfasser:	Wang, Lin, Xu, Hui, Li, Xin, Chen, Hongwei, Zhang, Haigang, Zhu, Xunpeng, Lin, Zhijie, Guo, Shilei, Bao, Zhibo, Rui, Haicheng, He, Wei, Zhang, Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Care and treatment Cartilage cells Development and progression Gene expression Genes Genetic aspects Genetic research Inflammation Interleukins Mice Molecular dynamics Osteoarthritis Physiological aspects Proteins
Online-Zugang:	Volltext
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