Effect of Butyl Paraben on Oxidative Stress in the Liver of IMauremys sinensis/I

Butyl paraben (BuP) has been widely used as a preservative in the cosmetics, food, and medicine industries. Recently, it has become a new pollutant and has attracted much attention. In order to evaluate the toxic effect of BuP on aquatic animals, Chinese striped-neck turtles (Mauremys sinensis) were...

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Veröffentlicht in:Toxics (Basel) 2023-11, Vol.11 (11)
Hauptverfasser: Yin, Yaru, Xie, Zhenzi, Sun, Xiao, Wu, Xia, Zhang, Jiliang, Shi, Haitao, Ding, Li, Hong, Meiling
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container_issue 11
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container_title Toxics (Basel)
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creator Yin, Yaru
Xie, Zhenzi
Sun, Xiao
Wu, Xia
Zhang, Jiliang
Shi, Haitao
Ding, Li
Hong, Meiling
description Butyl paraben (BuP) has been widely used as a preservative in the cosmetics, food, and medicine industries. Recently, it has become a new pollutant and has attracted much attention. In order to evaluate the toxic effect of BuP on aquatic animals, Chinese striped-neck turtles (Mauremys sinensis) were exposed to BuP solutions with different concentrations of 0, 5, 50, 500, and 5000 µg/L for 20 weeks. The results showed that with an increase in BuP concentration, the activity of antioxidant enzymes (SOD, CAT and GSH-PX) in liver decreased. The expression of key genes in the Nrf2-Keap1 signal pathways first increased and then decreased, while the expression of the HSP70 and HSP90 genes increased. In addition, the liver had an inflammatory reaction. The expression of the BAFF and IL-6 genes increased and then decreased with an increase in BuP concentration, while the expression of P50 and P65 increased significantly. Oxidative stress induced apoptosis, and the expression of pro-apoptosis genes (BAX, cytc, Caspase3 and Caspase9) increased, while the expression of the anti-apoptosis gene Bcl2 decreased. The results provide an important reference for the comprehensive ecological and health risk assessment of environmental BuP.
doi_str_mv 10.3390/toxics11110915
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Oxidative stress induced apoptosis, and the expression of pro-apoptosis genes (BAX, cytc, Caspase3 and Caspase9) increased, while the expression of the anti-apoptosis gene Bcl2 decreased. 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subjects Health aspects
Influence
Liver
Oxidative stress
Parabens
Physiological aspects
Turtles
title Effect of Butyl Paraben on Oxidative Stress in the Liver of IMauremys sinensis/I
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