Phenopyrrolizins A and B, Two Novel Pyrrolizine Alkaloids from Marine-Derived Actinomycetes IMicromonospora/I sp. HU138
Two previously undescribed pyrrolizine alkaloids, named phenopyrrolizins A and B (1 and 2), were obtained from the fermentation broth of marine-derived Micromonospora sp. HU138. Their structures were established by extensive spectroscopic analysis, including 1D and 2D NMR spectra as well as HRESIMS...
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| Veröffentlicht in: | Molecules (Basel, Switzerland) Switzerland), 2023-11, Vol.28 (22) |
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| creator | Zhang, Hui Ren, Xiaohan Xu, Haiju Qi, Huan Du, Shihua Huang, Jun Zhang, Ji Wang, Jidong |
| description | Two previously undescribed pyrrolizine alkaloids, named phenopyrrolizins A and B (1 and 2), were obtained from the fermentation broth of marine-derived Micromonospora sp. HU138. Their structures were established by extensive spectroscopic analysis, including 1D and 2D NMR spectra as well as HRESIMS data. The structure of 1 was confirmed by single-crystal diffraction analysis and its racemization mechanism was proposed. The antifungal activity assay showed that 2 could inhibit the mycelial growth of Botrytis cinerea with the inhibitory rates of 18.9% and 35.9% at 20 μg/disc and 40 μg/disc, respectively. |
| doi_str_mv | 10.3390/molecules28227672 |
| format | Article |
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HU138</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Zhang, Hui ; Ren, Xiaohan ; Xu, Haiju ; Qi, Huan ; Du, Shihua ; Huang, Jun ; Zhang, Ji ; Wang, Jidong</creator><creatorcontrib>Zhang, Hui ; Ren, Xiaohan ; Xu, Haiju ; Qi, Huan ; Du, Shihua ; Huang, Jun ; Zhang, Ji ; Wang, Jidong</creatorcontrib><description>Two previously undescribed pyrrolizine alkaloids, named phenopyrrolizins A and B (1 and 2), were obtained from the fermentation broth of marine-derived Micromonospora sp. HU138. Their structures were established by extensive spectroscopic analysis, including 1D and 2D NMR spectra as well as HRESIMS data. The structure of 1 was confirmed by single-crystal diffraction analysis and its racemization mechanism was proposed. The antifungal activity assay showed that 2 could inhibit the mycelial growth of Botrytis cinerea with the inhibitory rates of 18.9% and 35.9% at 20 μg/disc and 40 μg/disc, respectively.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules28227672</identifier><language>eng</language><publisher>MDPI AG</publisher><subject>Alkaloids ; Aminoglycosides ; Fermentation ; Plant metabolites</subject><ispartof>Molecules (Basel, Switzerland), 2023-11, Vol.28 (22)</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,861,27905,27906</link.rule.ids></links><search><creatorcontrib>Zhang, Hui</creatorcontrib><creatorcontrib>Ren, Xiaohan</creatorcontrib><creatorcontrib>Xu, Haiju</creatorcontrib><creatorcontrib>Qi, Huan</creatorcontrib><creatorcontrib>Du, Shihua</creatorcontrib><creatorcontrib>Huang, Jun</creatorcontrib><creatorcontrib>Zhang, Ji</creatorcontrib><creatorcontrib>Wang, Jidong</creatorcontrib><title>Phenopyrrolizins A and B, Two Novel Pyrrolizine Alkaloids from Marine-Derived Actinomycetes IMicromonospora/I sp. HU138</title><title>Molecules (Basel, Switzerland)</title><description>Two previously undescribed pyrrolizine alkaloids, named phenopyrrolizins A and B (1 and 2), were obtained from the fermentation broth of marine-derived Micromonospora sp. HU138. Their structures were established by extensive spectroscopic analysis, including 1D and 2D NMR spectra as well as HRESIMS data. The structure of 1 was confirmed by single-crystal diffraction analysis and its racemization mechanism was proposed. The antifungal activity assay showed that 2 could inhibit the mycelial growth of Botrytis cinerea with the inhibitory rates of 18.9% and 35.9% at 20 μg/disc and 40 μg/disc, respectively.</description><subject>Alkaloids</subject><subject>Aminoglycosides</subject><subject>Fermentation</subject><subject>Plant metabolites</subject><issn>1420-3049</issn><issn>1420-3049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptj01LAzEQhoMoWKs_wFvAq9vmazeb41o_Wmi1h3ouaXZSo9lN2dSW-usNKNKDDC8zvPO8A4PQNSUDzhUZNsGD-fQQWcmYLCQ7QT0qGMk4Eer0aD5HFzG-E8KooHkP7edv0IbNoeuCd1-ujbjCuq3x3S1e7AN-DjvweP63Blz5D-2DqyO2XWjwTHfJze6hczuocWW2rg3NwcAWIp7MnElQaEPchE4PJzhuBnj8Snl5ic6s9hGufnsfLR4fFqNxNn15moyqabYuJM1yYqlSZWFoklwVypqV5hyUBABpc8FWjEJ6VxFKLSllXRCRE1UYXqoiF7yPbn7OrrWHpWtt2HbaNC6aZSWl4EwIQhM1-IdKVUPjTGjBuuQfBb4B6WhubQ</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Zhang, Hui</creator><creator>Ren, Xiaohan</creator><creator>Xu, Haiju</creator><creator>Qi, Huan</creator><creator>Du, Shihua</creator><creator>Huang, Jun</creator><creator>Zhang, Ji</creator><creator>Wang, Jidong</creator><general>MDPI AG</general><scope/></search><sort><creationdate>20231101</creationdate><title>Phenopyrrolizins A and B, Two Novel Pyrrolizine Alkaloids from Marine-Derived Actinomycetes IMicromonospora/I sp. HU138</title><author>Zhang, Hui ; Ren, Xiaohan ; Xu, Haiju ; Qi, Huan ; Du, Shihua ; Huang, Jun ; Zhang, Ji ; Wang, Jidong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g671-50f19986c186c7b69fcba33e97eee7f542b21e7679011f087d6045096c3896543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alkaloids</topic><topic>Aminoglycosides</topic><topic>Fermentation</topic><topic>Plant metabolites</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Hui</creatorcontrib><creatorcontrib>Ren, Xiaohan</creatorcontrib><creatorcontrib>Xu, Haiju</creatorcontrib><creatorcontrib>Qi, Huan</creatorcontrib><creatorcontrib>Du, Shihua</creatorcontrib><creatorcontrib>Huang, Jun</creatorcontrib><creatorcontrib>Zhang, Ji</creatorcontrib><creatorcontrib>Wang, Jidong</creatorcontrib><jtitle>Molecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Hui</au><au>Ren, Xiaohan</au><au>Xu, Haiju</au><au>Qi, Huan</au><au>Du, Shihua</au><au>Huang, Jun</au><au>Zhang, Ji</au><au>Wang, Jidong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phenopyrrolizins A and B, Two Novel Pyrrolizine Alkaloids from Marine-Derived Actinomycetes IMicromonospora/I sp. HU138</atitle><jtitle>Molecules (Basel, Switzerland)</jtitle><date>2023-11-01</date><risdate>2023</risdate><volume>28</volume><issue>22</issue><issn>1420-3049</issn><eissn>1420-3049</eissn><abstract>Two previously undescribed pyrrolizine alkaloids, named phenopyrrolizins A and B (1 and 2), were obtained from the fermentation broth of marine-derived Micromonospora sp. HU138. Their structures were established by extensive spectroscopic analysis, including 1D and 2D NMR spectra as well as HRESIMS data. The structure of 1 was confirmed by single-crystal diffraction analysis and its racemization mechanism was proposed. The antifungal activity assay showed that 2 could inhibit the mycelial growth of Botrytis cinerea with the inhibitory rates of 18.9% and 35.9% at 20 μg/disc and 40 μg/disc, respectively.</abstract><pub>MDPI AG</pub><doi>10.3390/molecules28227672</doi></addata></record> |
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| ispartof | Molecules (Basel, Switzerland), 2023-11, Vol.28 (22) |
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| language | eng |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Alkaloids Aminoglycosides Fermentation Plant metabolites |
| title | Phenopyrrolizins A and B, Two Novel Pyrrolizine Alkaloids from Marine-Derived Actinomycetes IMicromonospora/I sp. HU138 |
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