IMLH1/I Promoter Methylation Could Be the Second Hit in Lynch Syndrome Carcinogenesis

(1) Background: MLH1 hypermethylation is an epigenetic alteration in the tumorigenesis of colorectal cancer (CRC) and endometrial cancer (EC), causing gene silencing, and, as a consequence, microsatellite instability. Commonly, MLH1 hypermethylation is considered a somatic and sporadic event in canc...

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Veröffentlicht in:	Genes 2023-11, Vol.14 (11)
Hauptverfasser:	Carnevali, Ileana Wanda, Cini, Giulia, Libera, Laura, Sahnane, Nora, Facchi, Sofia, Viel, Alessandra, Sessa, Fausto, Tibiletti, Maria Grazia
Format:	Artikel
Sprache:	eng
Schlagworte:	Colorectal cancer Epigenetic inheritance Genetic aspects Genetic engineering Medical genetics Methylation Ovarian cancer Scientific equipment and supplies industry Stomach cancer
Online-Zugang:	Volltext
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