Epigenetic Profiling of IPTPN11/I Mutant JMML Hematopoietic Stem and Progenitor Cells Reveals an Aberrant Histone Landscape

Juvenile myelomonocytic leukemia (JMML) is a deadly pediatric leukemia with limited treatment options and poor clinical outcomes. Effective targeted treatment strategies are an urgent unmet need. To improve outcomes for this pediatric patient population, we examined the structure of the DNA comprisi...

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Veröffentlicht in:	Cancers 2023-10, Vol.15 (21)
Hauptverfasser:	Sinha, Roshani, Dvorak, Mai, Ganesan, Ananthakrishnan, Kalesinskas, Larry, Niemeyer, Charlotte M, Flotho, Christian, Sakamoto, Kathleen M, Lacayo, Norman, Patil, Rachana Vinay, Perriman, Rhonda, Cepika, Alma-Ma, Liu, Yunying Lucy, Kuo, Alex, Utz, Paul J, Khatri, Purvesh, Bertaina, Alice
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimitotic agents Antineoplastic agents Cancer Care and treatment Children Chromatin Comparative analysis Development and progression Enzymes Epigenetic inheritance Ethylenediaminetetraacetic acid Genomes Genomics Health aspects Hematopoietic stem cells Leukemia Methylation Post-translational modification
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