Loss in the Antibacterial Ability of a PyrR Gene Regulating Pyrimidine Biosynthesis after Using CRISPR/Cas9-Mediated Knockout for Metabolic Engineering in ILactobacillus casei/I

Lactobacillus casei (L. casei) has four possible mechanisms: antimicrobial antagonism, competitional adhesion, immunoregulation, and the inhibition of bacterial toxins. To delineate the metabolic reactions of nucleotides from L. casei that are associated with mechanisms of inhibiting pathogens and i...

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Veröffentlicht in:	Microorganisms (Basel) 2023-09, Vol.11 (10)
Hauptverfasser:	Chen, Shaojun, He, Xinmiao, Qin, Ziliang, Li, Gang, Wang, Wentao, Nai, Zida, Tian, Yaguang, Liu, Di, Jiang, Xinpeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Genetic aspects Genetic regulation Lactobacillus Metabolic engineering Methods Microbiological research Microbiological synthesis Physiological aspects Production processes Pyrimidines
Online-Zugang:	Volltext
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