The outcomes of patients with kidney failure due to focal segmental glomerulosclerosis
The outcomes of patients with focal segmental glomerulosclerosis (FSGS) on kidney replacement therapy (KRT) have not been well described. This study evaluated the outcomes of patients with kidney failure due to FSGS on KRT including dialysis and kidney transplantation. All adult patients with kidney...
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| Veröffentlicht in: | PloS one 2023-11, Vol.18 (11), p.e0293721 |
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| description | The outcomes of patients with focal segmental glomerulosclerosis (FSGS) on kidney replacement therapy (KRT) have not been well described. This study evaluated the outcomes of patients with kidney failure due to FSGS on KRT including dialysis and kidney transplantation. All adult patients with kidney failure who commenced KRT in Australia and New Zealand from 15.sup.th of May 1963 to 31.sup.st of December 2018 were retrospectively extracted from the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry. Outcomes of patients with FSGS were compared to those with other causes of kidney failure (non-FSGS). 85,052 patients commenced KRT during the study period, of whom 2991 (3.5%) were patients with FSGS. Compared to patients with non-FSGS, patients with FSGS experienced similar mortality on dialysis (adjusted hazard ratio [aHR] 0.98, 95% CI 0.90-1.06, p = 0.55) and following kidney transplantation (aHR 0.92, 95% CI 0.73-1.15, p = 0.47). The risk of first kidney allograft loss was higher in patients with FSGS (aHR 1.20, 95% CI 1.04-1.37, p = 0.01). However, when death was analysed as a competing risk, the survival in both groups was similar (sub-hazard ratio [SHR] 1.09, 95% CI 0.94-1.28, p = 0.26). Patients with FSGS had a longer waiting time for kidney transplantation (aHR 0.92, 95% CI 0.86-0.98, p = 0.02) and experienced an increased risk of disease recurrence in the allograft (aHR 1.73, 95% CI 1.35-2.21, p |
| doi_str_mv | 10.1371/journal.pone.0293721 |
| format | Article |
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This study evaluated the outcomes of patients with kidney failure due to FSGS on KRT including dialysis and kidney transplantation. All adult patients with kidney failure who commenced KRT in Australia and New Zealand from 15.sup.th of May 1963 to 31.sup.st of December 2018 were retrospectively extracted from the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry. Outcomes of patients with FSGS were compared to those with other causes of kidney failure (non-FSGS). 85,052 patients commenced KRT during the study period, of whom 2991 (3.5%) were patients with FSGS. Compared to patients with non-FSGS, patients with FSGS experienced similar mortality on dialysis (adjusted hazard ratio [aHR] 0.98, 95% CI 0.90-1.06, p = 0.55) and following kidney transplantation (aHR 0.92, 95% CI 0.73-1.15, p = 0.47). The risk of first kidney allograft loss was higher in patients with FSGS (aHR 1.20, 95% CI 1.04-1.37, p = 0.01). However, when death was analysed as a competing risk, the survival in both groups was similar (sub-hazard ratio [SHR] 1.09, 95% CI 0.94-1.28, p = 0.26). Patients with FSGS had a longer waiting time for kidney transplantation (aHR 0.92, 95% CI 0.86-0.98, p = 0.02) and experienced an increased risk of disease recurrence in the allograft (aHR 1.73, 95% CI 1.35-2.21, p<0.001). Compared to patients with other forms of glomerular disease, patients with FSGS experienced similar dialysis and transplant patient survival and death-censored rate of kidney transplantation and allograft loss but higher rates of primary kidney disease recurrence. FSGS was associated with similar dialysis and transplant patient survival and death-censored first allograft loss compared to non-FSGS and other forms of glomerular disease.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0293721</identifier><language>eng</language><publisher>Public Library of Science</publisher><subject>Australia ; Care and treatment ; Censorship ; Comparative analysis ; Complications and side effects ; Diagnosis ; Diseases ; Evaluation ; Kidney failure ; Medical research ; Medicine, Experimental ; Mortality ; Nephrectomy ; New Zealand ; Patient outcomes ; Relapse ; Transplantation of organs, tissues, etc</subject><ispartof>PloS one, 2023-11, Vol.18 (11), p.e0293721</ispartof><rights>COPYRIGHT 2023 Public Library of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27903,27904</link.rule.ids></links><search><creatorcontrib>Bose, Bhadran</creatorcontrib><creatorcontrib>Milanzi, Elasma</creatorcontrib><creatorcontrib>Pascoe, Elaine M</creatorcontrib><creatorcontrib>Johnson, David W</creatorcontrib><creatorcontrib>Badve, Sunil V</creatorcontrib><title>The outcomes of patients with kidney failure due to focal segmental glomerulosclerosis</title><title>PloS one</title><description>The outcomes of patients with focal segmental glomerulosclerosis (FSGS) on kidney replacement therapy (KRT) have not been well described. This study evaluated the outcomes of patients with kidney failure due to FSGS on KRT including dialysis and kidney transplantation. All adult patients with kidney failure who commenced KRT in Australia and New Zealand from 15.sup.th of May 1963 to 31.sup.st of December 2018 were retrospectively extracted from the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry. Outcomes of patients with FSGS were compared to those with other causes of kidney failure (non-FSGS). 85,052 patients commenced KRT during the study period, of whom 2991 (3.5%) were patients with FSGS. Compared to patients with non-FSGS, patients with FSGS experienced similar mortality on dialysis (adjusted hazard ratio [aHR] 0.98, 95% CI 0.90-1.06, p = 0.55) and following kidney transplantation (aHR 0.92, 95% CI 0.73-1.15, p = 0.47). The risk of first kidney allograft loss was higher in patients with FSGS (aHR 1.20, 95% CI 1.04-1.37, p = 0.01). However, when death was analysed as a competing risk, the survival in both groups was similar (sub-hazard ratio [SHR] 1.09, 95% CI 0.94-1.28, p = 0.26). Patients with FSGS had a longer waiting time for kidney transplantation (aHR 0.92, 95% CI 0.86-0.98, p = 0.02) and experienced an increased risk of disease recurrence in the allograft (aHR 1.73, 95% CI 1.35-2.21, p<0.001). Compared to patients with other forms of glomerular disease, patients with FSGS experienced similar dialysis and transplant patient survival and death-censored rate of kidney transplantation and allograft loss but higher rates of primary kidney disease recurrence. FSGS was associated with similar dialysis and transplant patient survival and death-censored first allograft loss compared to non-FSGS and other forms of glomerular disease.</description><subject>Australia</subject><subject>Care and treatment</subject><subject>Censorship</subject><subject>Comparative analysis</subject><subject>Complications and side effects</subject><subject>Diagnosis</subject><subject>Diseases</subject><subject>Evaluation</subject><subject>Kidney failure</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Mortality</subject><subject>Nephrectomy</subject><subject>New Zealand</subject><subject>Patient outcomes</subject><subject>Relapse</subject><subject>Transplantation of organs, tissues, etc</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqN0EtLAzEQB_AgCtbqN_AQEAQPu-axj-yxFB-FQkFrryXNTnZT003ZZFG_vQE9tOBB5jDD8PvPYRC6piSlvKT3Wzf0nbTp3nWQElbxktETNKIVZ0nBCD89mM_RhfdbQnIuimKEVssWsBuCcjvw2Gm8l8FAFzz-MKHF76bu4AtraezQA64HwMFh7ZS02EOzizJOjY3pfrDOKwu988ZfojMtrYer3z5Gb48Py-lzMl88zaaTedLQomDJRjNaVpkgSgiRV0xLmWe8UlqqLJOFoozXlJW10ApgUwtJ6hyUkmTDK6Ay52N083O3kRbWptMu9FLtjFfrSVnSeF1wFlX6h4pVw86o-DRt4v4ocHcUiCbAZ2jk4P169vryf7tYHdvbA9uCtKH1zg7BuM4fwm-ThI-n</recordid><startdate>20231102</startdate><enddate>20231102</enddate><creator>Bose, Bhadran</creator><creator>Milanzi, Elasma</creator><creator>Pascoe, Elaine M</creator><creator>Johnson, David W</creator><creator>Badve, Sunil V</creator><general>Public Library of Science</general><scope>IOV</scope><scope>ISR</scope></search><sort><creationdate>20231102</creationdate><title>The outcomes of patients with kidney failure due to focal segmental glomerulosclerosis</title><author>Bose, Bhadran ; Milanzi, Elasma ; Pascoe, Elaine M ; Johnson, David W ; Badve, Sunil V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g1662-bf2179480c888592faa5439cfac44a6c123d127d8fceebd8a0d5ecca0b39e1a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Australia</topic><topic>Care and treatment</topic><topic>Censorship</topic><topic>Comparative analysis</topic><topic>Complications and side effects</topic><topic>Diagnosis</topic><topic>Diseases</topic><topic>Evaluation</topic><topic>Kidney failure</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Mortality</topic><topic>Nephrectomy</topic><topic>New Zealand</topic><topic>Patient outcomes</topic><topic>Relapse</topic><topic>Transplantation of organs, tissues, etc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bose, Bhadran</creatorcontrib><creatorcontrib>Milanzi, Elasma</creatorcontrib><creatorcontrib>Pascoe, Elaine M</creatorcontrib><creatorcontrib>Johnson, David W</creatorcontrib><creatorcontrib>Badve, Sunil V</creatorcontrib><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bose, Bhadran</au><au>Milanzi, Elasma</au><au>Pascoe, Elaine M</au><au>Johnson, David W</au><au>Badve, Sunil V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The outcomes of patients with kidney failure due to focal segmental glomerulosclerosis</atitle><jtitle>PloS one</jtitle><date>2023-11-02</date><risdate>2023</risdate><volume>18</volume><issue>11</issue><spage>e0293721</spage><pages>e0293721-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The outcomes of patients with focal segmental glomerulosclerosis (FSGS) on kidney replacement therapy (KRT) have not been well described. This study evaluated the outcomes of patients with kidney failure due to FSGS on KRT including dialysis and kidney transplantation. All adult patients with kidney failure who commenced KRT in Australia and New Zealand from 15.sup.th of May 1963 to 31.sup.st of December 2018 were retrospectively extracted from the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry. Outcomes of patients with FSGS were compared to those with other causes of kidney failure (non-FSGS). 85,052 patients commenced KRT during the study period, of whom 2991 (3.5%) were patients with FSGS. Compared to patients with non-FSGS, patients with FSGS experienced similar mortality on dialysis (adjusted hazard ratio [aHR] 0.98, 95% CI 0.90-1.06, p = 0.55) and following kidney transplantation (aHR 0.92, 95% CI 0.73-1.15, p = 0.47). The risk of first kidney allograft loss was higher in patients with FSGS (aHR 1.20, 95% CI 1.04-1.37, p = 0.01). However, when death was analysed as a competing risk, the survival in both groups was similar (sub-hazard ratio [SHR] 1.09, 95% CI 0.94-1.28, p = 0.26). Patients with FSGS had a longer waiting time for kidney transplantation (aHR 0.92, 95% CI 0.86-0.98, p = 0.02) and experienced an increased risk of disease recurrence in the allograft (aHR 1.73, 95% CI 1.35-2.21, p<0.001). Compared to patients with other forms of glomerular disease, patients with FSGS experienced similar dialysis and transplant patient survival and death-censored rate of kidney transplantation and allograft loss but higher rates of primary kidney disease recurrence. FSGS was associated with similar dialysis and transplant patient survival and death-censored first allograft loss compared to non-FSGS and other forms of glomerular disease.</abstract><pub>Public Library of Science</pub><doi>10.1371/journal.pone.0293721</doi><tpages>e0293721</tpages></addata></record> |
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| subjects | Australia Care and treatment Censorship Comparative analysis Complications and side effects Diagnosis Diseases Evaluation Kidney failure Medical research Medicine, Experimental Mortality Nephrectomy New Zealand Patient outcomes Relapse Transplantation of organs, tissues, etc |
| title | The outcomes of patients with kidney failure due to focal segmental glomerulosclerosis |
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