Development and validation of a prognostic model for non-lung cancer death in elderly patients treated with stereotactic body radiotherapy for non-small cell lung cancer
This study sought to develop and validate a prognostic model for non-lung cancer death (NLCD) in elderly patients with non-small cell lung cancer (NSCLC) treated with stereotactic body radiotherapy (SBRT). Patients aged >= 65 diagnosed with NSCLC (Tis-4NOMO), tumor diameter = 2), 2.5 (CCI 1 or 2)...
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| Veröffentlicht in: | Journal of radiation research 2021-11, Vol.62 (6), p.1029-1038 |
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| container_title | Journal of radiation research |
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| creator | Hanazawa, Hideki Matsuo, Yukinori Takeda, Atsuya Tsurugai, Yuichiro Iizuka, Yusuke Kishi, Noriko Takehana, Keiichi Mizowaki, Takashi |
| description | This study sought to develop and validate a prognostic model for non-lung cancer death (NLCD) in elderly patients with non-small cell lung cancer (NSCLC) treated with stereotactic body radiotherapy (SBRT). Patients aged >= 65 diagnosed with NSCLC (Tis-4NOMO), tumor diameter = 2), 2.5 (CCI 1 or 2) and 3 (CCI >= 3) were assigned, and risk groups were designated as low (total = 4.5). The cumulative incidences of NLCD at 5 years in the low, intermediate and high-risk groups were 6.8, 23 and 40% in arm D, and 23, 19 and 44% in arm V, respectively. The AUC index at 5 years was 0.705 (arm D) and 0.632 (arm V). The proposed scoring system showed usefulness in predicting a high risk of NLCD in elderly patients treated with SBRT for NSCLC. |
| doi_str_mv | 10.1093/jrr/rrab093 |
| format | Article |
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Patients aged >= 65 diagnosed with NSCLC (Tis-4NOMO), tumor diameter <= 5 cm and SBRT between 1998 and 2015 were retrospectively registered from two independent institutions. One institution was used for model development (arm D, 353 patients) and the other for validation (arm V, 401 patients). To identify risk factors for NLCD, multiple regression analysis on age, sex, performance status (PS), body mass index (BMI), Charlson comorbidity index (CCI), tumor diameter, histology and T-stage was performed on arm D. A score calculated using the regression coefficient was assigned to each factor and three risk groups were defined based on total score. Scores of 1.0 (BMI <= 18.4), 1.5 (age >= 5), 1.5 (PS >= 2), 2.5 (CCI 1 or 2) and 3 (CCI >= 3) were assigned, and risk groups were designated as low (total <= 3), intermediate (3.5 or 4) and high (>= 4.5). The cumulative incidences of NLCD at 5 years in the low, intermediate and high-risk groups were 6.8, 23 and 40% in arm D, and 23, 19 and 44% in arm V, respectively. The AUC index at 5 years was 0.705 (arm D) and 0.632 (arm V). The proposed scoring system showed usefulness in predicting a high risk of NLCD in elderly patients treated with SBRT for NSCLC.</description><identifier>ISSN: 0449-3060</identifier><identifier>EISSN: 1349-9157</identifier><identifier>DOI: 10.1093/jrr/rrab093</identifier><identifier>PMID: 34617109</identifier><language>eng</language><publisher>OXFORD: Oxford Univ Press</publisher><subject>Aged patients ; Analysis ; Biology ; Body mass index ; Cancer ; Care and treatment ; Comorbidity ; Life Sciences & Biomedicine ; Life Sciences & Biomedicine - Other Topics ; Lung cancer, Non-small cell ; Lung cancer, Small cell ; Oncology ; Oncology, Experimental ; Radiology, Nuclear Medicine & Medical Imaging ; Radiotherapy ; Risk factors ; Science & Technology</subject><ispartof>Journal of radiation research, 2021-11, Vol.62 (6), p.1029-1038</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology.</rights><rights>COPYRIGHT 2021 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>3</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000745622900011</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c391t-f9d8dcbf2df0fe59bdf236499b5b7c5f07f86edda9f7466ff74ad49d506c3f2d3</citedby><cites>FETCH-LOGICAL-c391t-f9d8dcbf2df0fe59bdf236499b5b7c5f07f86edda9f7466ff74ad49d506c3f2d3</cites><orcidid>0000-0001-5007-8808 ; 0000-0002-4372-8259 ; 0000-0003-2820-0760</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,865,2115,27929,27930,39263</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34617109$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hanazawa, Hideki</creatorcontrib><creatorcontrib>Matsuo, Yukinori</creatorcontrib><creatorcontrib>Takeda, Atsuya</creatorcontrib><creatorcontrib>Tsurugai, Yuichiro</creatorcontrib><creatorcontrib>Iizuka, Yusuke</creatorcontrib><creatorcontrib>Kishi, Noriko</creatorcontrib><creatorcontrib>Takehana, Keiichi</creatorcontrib><creatorcontrib>Mizowaki, Takashi</creatorcontrib><title>Development and validation of a prognostic model for non-lung cancer death in elderly patients treated with stereotactic body radiotherapy for non-small cell lung cancer</title><title>Journal of radiation research</title><addtitle>J RADIAT RES</addtitle><addtitle>J Radiat Res</addtitle><description>This study sought to develop and validate a prognostic model for non-lung cancer death (NLCD) in elderly patients with non-small cell lung cancer (NSCLC) treated with stereotactic body radiotherapy (SBRT). Patients aged >= 65 diagnosed with NSCLC (Tis-4NOMO), tumor diameter <= 5 cm and SBRT between 1998 and 2015 were retrospectively registered from two independent institutions. One institution was used for model development (arm D, 353 patients) and the other for validation (arm V, 401 patients). To identify risk factors for NLCD, multiple regression analysis on age, sex, performance status (PS), body mass index (BMI), Charlson comorbidity index (CCI), tumor diameter, histology and T-stage was performed on arm D. A score calculated using the regression coefficient was assigned to each factor and three risk groups were defined based on total score. Scores of 1.0 (BMI <= 18.4), 1.5 (age >= 5), 1.5 (PS >= 2), 2.5 (CCI 1 or 2) and 3 (CCI >= 3) were assigned, and risk groups were designated as low (total <= 3), intermediate (3.5 or 4) and high (>= 4.5). The cumulative incidences of NLCD at 5 years in the low, intermediate and high-risk groups were 6.8, 23 and 40% in arm D, and 23, 19 and 44% in arm V, respectively. The AUC index at 5 years was 0.705 (arm D) and 0.632 (arm V). The proposed scoring system showed usefulness in predicting a high risk of NLCD in elderly patients treated with SBRT for NSCLC.</description><subject>Aged patients</subject><subject>Analysis</subject><subject>Biology</subject><subject>Body mass index</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Comorbidity</subject><subject>Life Sciences & Biomedicine</subject><subject>Life Sciences & Biomedicine - Other Topics</subject><subject>Lung cancer, Non-small cell</subject><subject>Lung cancer, Small cell</subject><subject>Oncology</subject><subject>Oncology, Experimental</subject><subject>Radiology, Nuclear Medicine & Medical Imaging</subject><subject>Radiotherapy</subject><subject>Risk factors</subject><subject>Science & Technology</subject><issn>0449-3060</issn><issn>1349-9157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><recordid>eNqNkk2PFCEQhonRuOPqybsh8WJiehf6gx6Om_Ez2cSLnjs0FLNsaGiB3s38pP2X1jjjqIkHQ1JU4KmXghdCXnJ2wZlsLm9TukxJjZg_IivetLKSvOsfkxVrMW-YYGfkWc63jNU969hTcta0gvdYvCIP7-AOfJwnCIWqYOid8s6o4mKg0VJF5xS3IebiNJ2iAU9tTDTEUPklbKlWQUOiBlS5oS5Q8AaS39EZFVAx05JwCwy9dwjkAgliUXqvNkazo0kZF8sNJDXvTsp5Ut5TDRj-OOQ5eWKVz_DiOJ-Tbx_ef918qq6_fPy8ubqudCN5qaw0a6NHWxvLLHRyNLZuRCvl2I297izr7VqAMUravhXCYlSmlaZjQjdY1ZyTNwddvPn3BXIZJpf3zagAcclD3a3xIQWXNaKvD-hWeRhcsLEkpff4cNULyXldt2ukLv5B4TAwOR0DWIfrfxW8PRToFHNOYIc5uUml3cDZsLd8QMuHo-VIvzr2u4wTmBP7y-PfcvcwRps1GqPhhDHG-rYTdS0x4xzp9f_TG1d-fpVNXEJpfgCExs0r</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Hanazawa, Hideki</creator><creator>Matsuo, Yukinori</creator><creator>Takeda, Atsuya</creator><creator>Tsurugai, Yuichiro</creator><creator>Iizuka, Yusuke</creator><creator>Kishi, Noriko</creator><creator>Takehana, Keiichi</creator><creator>Mizowaki, Takashi</creator><general>Oxford Univ Press</general><general>Oxford University Press</general><scope>95M</scope><scope>AFTVD</scope><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5007-8808</orcidid><orcidid>https://orcid.org/0000-0002-4372-8259</orcidid><orcidid>https://orcid.org/0000-0003-2820-0760</orcidid></search><sort><creationdate>20211101</creationdate><title>Development and validation of a prognostic model for non-lung cancer death in elderly patients treated with stereotactic body radiotherapy for non-small cell lung cancer</title><author>Hanazawa, Hideki ; Matsuo, Yukinori ; Takeda, Atsuya ; Tsurugai, Yuichiro ; Iizuka, Yusuke ; Kishi, Noriko ; Takehana, Keiichi ; Mizowaki, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-f9d8dcbf2df0fe59bdf236499b5b7c5f07f86edda9f7466ff74ad49d506c3f2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged patients</topic><topic>Analysis</topic><topic>Biology</topic><topic>Body mass index</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Comorbidity</topic><topic>Life Sciences & Biomedicine</topic><topic>Life Sciences & Biomedicine - Other Topics</topic><topic>Lung cancer, Non-small cell</topic><topic>Lung cancer, Small cell</topic><topic>Oncology</topic><topic>Oncology, Experimental</topic><topic>Radiology, Nuclear Medicine & Medical Imaging</topic><topic>Radiotherapy</topic><topic>Risk factors</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hanazawa, Hideki</creatorcontrib><creatorcontrib>Matsuo, Yukinori</creatorcontrib><creatorcontrib>Takeda, Atsuya</creatorcontrib><creatorcontrib>Tsurugai, Yuichiro</creatorcontrib><creatorcontrib>Iizuka, Yusuke</creatorcontrib><creatorcontrib>Kishi, Noriko</creatorcontrib><creatorcontrib>Takehana, Keiichi</creatorcontrib><creatorcontrib>Mizowaki, Takashi</creatorcontrib><collection>Conference Proceedings Citation Index - Science (CPCI-S)</collection><collection>Conference Proceedings Citation Index - Science (CPCI-S) 2021</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of radiation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hanazawa, Hideki</au><au>Matsuo, Yukinori</au><au>Takeda, Atsuya</au><au>Tsurugai, Yuichiro</au><au>Iizuka, Yusuke</au><au>Kishi, Noriko</au><au>Takehana, Keiichi</au><au>Mizowaki, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development and validation of a prognostic model for non-lung cancer death in elderly patients treated with stereotactic body radiotherapy for non-small cell lung cancer</atitle><jtitle>Journal of radiation research</jtitle><stitle>J RADIAT RES</stitle><addtitle>J Radiat Res</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>62</volume><issue>6</issue><spage>1029</spage><epage>1038</epage><pages>1029-1038</pages><issn>0449-3060</issn><eissn>1349-9157</eissn><abstract>This study sought to develop and validate a prognostic model for non-lung cancer death (NLCD) in elderly patients with non-small cell lung cancer (NSCLC) treated with stereotactic body radiotherapy (SBRT). Patients aged >= 65 diagnosed with NSCLC (Tis-4NOMO), tumor diameter <= 5 cm and SBRT between 1998 and 2015 were retrospectively registered from two independent institutions. One institution was used for model development (arm D, 353 patients) and the other for validation (arm V, 401 patients). To identify risk factors for NLCD, multiple regression analysis on age, sex, performance status (PS), body mass index (BMI), Charlson comorbidity index (CCI), tumor diameter, histology and T-stage was performed on arm D. A score calculated using the regression coefficient was assigned to each factor and three risk groups were defined based on total score. Scores of 1.0 (BMI <= 18.4), 1.5 (age >= 5), 1.5 (PS >= 2), 2.5 (CCI 1 or 2) and 3 (CCI >= 3) were assigned, and risk groups were designated as low (total <= 3), intermediate (3.5 or 4) and high (>= 4.5). The cumulative incidences of NLCD at 5 years in the low, intermediate and high-risk groups were 6.8, 23 and 40% in arm D, and 23, 19 and 44% in arm V, respectively. The AUC index at 5 years was 0.705 (arm D) and 0.632 (arm V). The proposed scoring system showed usefulness in predicting a high risk of NLCD in elderly patients treated with SBRT for NSCLC.</abstract><cop>OXFORD</cop><pub>Oxford Univ Press</pub><pmid>34617109</pmid><doi>10.1093/jrr/rrab093</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5007-8808</orcidid><orcidid>https://orcid.org/0000-0002-4372-8259</orcidid><orcidid>https://orcid.org/0000-0003-2820-0760</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged patients Analysis Biology Body mass index Cancer Care and treatment Comorbidity Life Sciences & Biomedicine Life Sciences & Biomedicine - Other Topics Lung cancer, Non-small cell Lung cancer, Small cell Oncology Oncology, Experimental Radiology, Nuclear Medicine & Medical Imaging Radiotherapy Risk factors Science & Technology |
| title | Development and validation of a prognostic model for non-lung cancer death in elderly patients treated with stereotactic body radiotherapy for non-small cell lung cancer |
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