Valproic acid triggers radiation-induced abscopal effect by modulating the unirradiated tumor immune microenvironment in a rat model of breast cancer

An abscopal effect occurs when localized radiotherapy causes the regression of tumors distant from the irradiated site. However, such a clinically detectable abscopal effect from radiotherapy alone is rare. This study investigated whether valproic acid ([VPA], a histone deacetylase inhibitor [HDACi]...

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Veröffentlicht in:	Journal of radiation research 2021-11, Vol.62 (6), p.955-965
Hauptverfasser:	Jin, Liya, Duan, Wenhua, Cai, Zuchao, Lim, David, Feng, Zhihui
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Divalproex Health aspects Immunohistochemistry Macrophages Radiation Radiotherapy T cells Transforming growth factors Valproic acid
Online-Zugang:	Volltext
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