Indomethacin Induces Spermidine/Spermine-N[sup.1]-Acetyltransferase-1 via the Nucleolin-CDK1 Axis and Synergizes with the Polyamine Oxidase Inhibitor Methoctramine in Lung Cancer Cells

Indomethacin is a non-selective NSAID used against pain and inflammation. Although cyclooxygenase (COX) inhibition is considered indomethacin’s primary action mechanism, COX-independent ways are associated with beneficial effects in cancer. In colon cancer cells, the activation of the peroxisome pro...

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Veröffentlicht in:	Biomolecules (Basel, Switzerland) Switzerland), 2023-09, Vol.13 (9)
Hauptverfasser:	Buelvas, Neudo, Ugarte-Vio, Isidora, Asencio-Leal, Laura, Muñoz-Uribe, Matías, Ma, Rojas-Fernández, Alejandro, Jara, José A, Tapia, Julio C, Arias, María Elena, López-Muñoz, Rodrigo A
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical properties Drug synergism Drug therapy Health aspects Indomethacin Lung cancer, Non-small cell Muscarinic antagonists Pharmacology, Experimental Physiological aspects Polyamines Transferases
Online-Zugang:	Volltext
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